INT113566

Context Info Confidence 0.55 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.70 Pain Relevance 0.67

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency PC-3 2 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 18 99.24 cINOD 6 94.32 COX-2 inhibitor 6 57.68 metalloproteinase 3 5.00 COX2 1 5.00 cytokine 1 5.00 Inflammation 1 5.00 Osteoarthritis 1 5.00

Disease Link Frequency Relevance Heat Cancer 68 99.84 Prostate Cancer 8 98.72 Carcinoma 12 97.44 Pancreatic Cancer 2 97.40 INFLAMMATION 6 93.56 Adhesions 8 90.40 Knee Osteoarthritis 1 80.68 Metastasis 19 79.40 Osteoarthritis 1 50.00 Skin Cancer 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here we show that aspirin inhibits NF-kappaB, resulting in the suppression of uPA secretion from the highly invasive human prostate cancer cells PC-3.

Negative_regulation (suppression) of Localization (secretion) of uPA in PC-3 associated with aspirin and prostate cancer

1) Confidence 0.55 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 1.06 Pain Relevance 0.35

ELISA showed the inhibitions of u-PA secretion in chondral cultures by diclofenac and rofecoxib as well as in chondral and synovial cultures by nimesulide, celecoxib and etoricoxib at 48 h.

Negative_regulation (inhibitions) of Localization (secretion) of u-PA

2) Confidence 0.55 Published 2008 Journal Clin. Biochem. Section Body Doc Link 17996201 Disease Relevance 0.08 Pain Relevance 0

We have recently demonstrated that constitutively active nuclear factor-kappa B (NF-kappaB) is responsible for the increased secretion of uPA and that inhibition of NF-kappaB suppresses secretion of uPA and cell migration of highly invasive cancer cells.

Negative_regulation (suppresses) of Localization (secretion) of uPA associated with cancer

3) Confidence 0.41 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.96 Pain Relevance 0.29

COX-2, MMPs, and uPA-system inhibition impacts on neo-angiogenic potential of tumour cells

Negative_regulation (inhibition) of Localization (potential) of uPA associated with cancer

4) Confidence 0.13 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.60 Pain Relevance 0.03

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