INT113568

Context Info Confidence 0.94 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 4.79 Pain Relevance 0.57

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency extracellular matrix 4 vessels 1 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat chemokine 1 94.56 metalloproteinase 76 89.20 Inflammation 6 87.84 cytokine 3 84.24 aspirin 10 75.00 COX-2 inhibitor 25 70.64 cINOD 3 65.68 methotrexate 1 46.80 COX2 2 5.00 palliative 1 5.00

Disease Link Frequency Relevance Heat Metastasis 38 100.00 Cancer 174 98.92 Advanced Or Metastatic Breast Cancer 5 98.40 Adhesions 5 96.68 Wound Healing 6 96.60 Breast Cancer 114 91.52 Disease 10 88.28 INFLAMMATION 8 87.84 Prostate Cancer 7 75.00 Injury 15 65.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition to the proteolytic activity of uPA, which degrades the extracellular matrix, uPA also binds to its receptor (uPAR) and controls cell adhesion and migration through the reorganization of actin cytoskeleton.

Protein_catabolism (degrades) of uPA in extracellular matrix associated with adhesions

1) Confidence 0.94 Published 2003 Journal Int. J. Oncol. Section Abstract Doc Link 14532966 Disease Relevance 0.82 Pain Relevance 0.16

In turn, de novo formed vessels strengthen tumour invasion and metastasis through the production of MMP 2 and 9 and uPA, which further degrade ECM.

Protein_catabolism (degrade) of uPA in vessels associated with cancer and metastasis

2) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2841144 Disease Relevance 0.99 Pain Relevance 0

For example, uPA, uPAR and its inhibitor PAI-1 are responsible for the degradation and remodeling of the extracellular matrix, and are further involved in angiogenesis, cell adhesion and migration necessary for tumor cell invasion and metastasis [31,32].

Protein_catabolism (degradation) of uPA in extracellular matrix associated with cancer, metastasis and adhesions

3) Confidence 0.29 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 1.25 Pain Relevance 0.21

The urokinase-type plasminogen activator (uPA) is a serine protease that plays an important role in the invasion and metastasis process through degradation of the extracellular matrix.

Protein_catabolism (degradation) of uPA in extracellular matrix associated with metastasis

4) Confidence 0.24 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC400674 Disease Relevance 0.88 Pain Relevance 0

The uPA activates proteases and MMPs that degrade the basement membrane and mediate cytoskeleton reorganization. [6,12,14].

Protein_catabolism (degrade) of uPA in basement membrane

5) Confidence 0.12 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.86 Pain Relevance 0.19

General Comments

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