INT11357

Context Info Confidence 0.56 First Reported 1992 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 10 Total Number 10 Disease Relevance 5.30 Pain Relevance 2.38

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency fibroblasts 6 synovium 2 PGE2 2 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 12 99.64 cINOD 19 99.38 rheumatoid arthritis 10 99.36 aspirin 10 89.36 Inflammation 21 83.04 adenocard 2 9.48 palliative 2 5.00 COX2 2 5.00 metalloproteinase 2 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Injury 3 99.66 Osteoarthritis 12 99.64 Rheumatoid Arthritis 12 99.36 Colon Cancer 81 97.68 Arthritis 4 96.52 Metastasis 15 96.08 INFLAMMATION 26 93.40 Cancer 49 90.16 Apoptosis 22 78.84 Breast Cancer 36 75.88

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

When gastric fibroblasts were treated with 50 microM indomethacin, the expression level of uPA mRNA decreased significantly, and the amount of uPA antigen in the culture medium and on cell surfaces decreased significantly with indomethacin in a dose-dependent manner.

Negative_regulation (decreased) of Gene_expression (expression) of uPA mRNA in fibroblasts

1) Confidence 0.56 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.48 Pain Relevance 0.10

RESULTS: Nimesulide and naproxen induced a dose-dependent decrease in uPA synthesis.

Negative_regulation (decrease) of Gene_expression (synthesis) of uPA

2) Confidence 0.53 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0

Univariate and multivariate analysis of uPA and PAI-1 mRNA values for MFS

Negative_regulation (analysis) of Gene_expression (values) of uPA

3) Confidence 0.42 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.68 Pain Relevance 0

When gastric fibroblasts were treated with 50 microM indomethacin, the expression level of uPA mRNA decreased significantly, and the amount of uPA antigen in the culture medium and on cell surfaces decreased significantly with indomethacin in a dose-dependent manner.

Negative_regulation (decreased) of Gene_expression (expression) of uPA mRNA in fibroblasts

4) Confidence 0.42 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.49 Pain Relevance 0.10

These results suggest that uPA and uPAR expression in gastric fibroblasts is involved in the regulating system of PGE2 and that NSAIDs may delay healing of gastric mucosal injury in part through suppressing uPA production via inhibition of endogenous PG production.

Negative_regulation (suppressing) of Gene_expression (production) of uPA in PGE2 associated with injury and cinod

5) Confidence 0.41 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.26 Pain Relevance 0.14

Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.

Negative_regulation (reduce) of Gene_expression (synthesis) of urokinase in fibroblasts associated with cinod

6) Confidence 0.38 Published 1997 Journal Clin. Exp. Rheumatol. Section Title Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0.33

Tiaprofenic acid induced a dose-dependent decrease in uPA synthesis in both OA and RA, particularly in OA synovium, but had no true effect on tPA.

Negative_regulation (decrease) of Gene_expression (synthesis) of uPA in synovium associated with rheumatoid arthritis and osteoarthritis

7) Confidence 0.38 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 1.22 Pain Relevance 0.57

The results of this study indicate that a decrease in uPA synthesis may be one of the mechanisms by which tiaprofenic acid could exert its effects on the arthritic process.

Negative_regulation (decrease) of Gene_expression (synthesis) of uPA associated with arthritis

8) Confidence 0.38 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 1.18 Pain Relevance 0.53

In our study, curcumin downregulated expression of PLAU in HT29 cells (Figure 3).

Negative_regulation (downregulated) of Gene_expression (expression) of PLAU

9) Confidence 0.36 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.46 Pain Relevance 0

In our study a similar response was found, as curcumin reduced expression of PCNA, TP53 and PLAU (uPA).

Negative_regulation (reduced) of Gene_expression (expression) of PLAU

10) Confidence 0.30 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.34 Pain Relevance 0.61

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