INT113572

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 1.90

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cell differentiation (DMRT1) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1)
plasma membrane (OPRM1) nucleus (DMRT1) signal transducer activity (OPRM1)
DMRT1 (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 8 100.00 Very High Very High Very High
Analgesic 4 98.16 Very High Very High Very High
intrathecal 4 97.04 Very High Very High Very High
Enkephalin 4 93.68 High High
Spinal cord 4 86.64 High High
opioid receptor 4 81.36 Quite High
Kappa opioid receptor 8 75.00 Quite High
Opioid 4 62.00 Quite High
agonist 8 29.84 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dissociation of [3H][Dmt1]DALDA was also rapid (K(-1) = 0.032 min(-1)) and indicated binding to a single site. [3H][Dmt1]DALDA binds with very high affinity to human mu opioid receptor (hMOR) (Kd = 0.199 nM), and Kd and Bmax were reduced by sodium but not Gpp(NH)p [guanosine 5'-(beta,gamma-imido)triphosphate].
Dmt1 Binding (binds) of hMOR associated with mu opioid receptor
1) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14534366 Disease Relevance 0 Pain Relevance 0.52
[Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt = 2',6'-dimethyltyrosine) binds with high affinity and selectivity to the mu opioid receptor and is a surprisingly potent and long-acting analgesic, especially after intrathecal administration.
Dmt1 Binding (binds) of mu opioid receptor associated with analgesic, mu opioid receptor and intrathecal
2) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14534366 Disease Relevance 0 Pain Relevance 0.33
Dissociation of [3H][Dmt1]DALDA was also rapid (K(-1) = 0.032 min(-1)) and indicated binding to a single site. [3H][Dmt1]DALDA binds with very high affinity to human mu opioid receptor (hMOR) (Kd = 0.199 nM), and Kd and Bmax were reduced by sodium but not Gpp(NH)p [guanosine 5'-(beta,gamma-imido)triphosphate].
Dmt1 Binding (binds) of hMOR associated with mu opioid receptor
3) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14534366 Disease Relevance 0 Pain Relevance 0.53
Dissociation of [3H][Dmt1]DALDA was also rapid (K(-1) = 0.032 min(-1)) and indicated binding to a single site. [3H][Dmt1]DALDA binds with very high affinity to human mu opioid receptor (hMOR) (Kd = 0.199 nM), and Kd and Bmax were reduced by sodium but not Gpp(NH)p [guanosine 5'-(beta,gamma-imido)triphosphate].
Dmt1 Binding (binds) of mu opioid receptor associated with mu opioid receptor
4) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14534366 Disease Relevance 0 Pain Relevance 0.53

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