INT11359

Context Info Confidence 0.76 First Reported 1985 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 84 Total Number 90 Disease Relevance 49.54 Pain Relevance 12.31

peptidase activity (PLAU) signal transduction (PLAU) extracellular space (PLAU) extracellular region (PLAU) plasma membrane (PLAU)

Anatomy Link Frequency fibroblasts 9 EOMA 5 lymph node 4 CSF 3 PGE2 3 PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 604 100.00 cINOD 86 99.84 Osteoarthritis 24 99.64 Inflammation 126 99.58 rheumatoid arthritis 15 99.36 cytokine 21 99.04 headache 14 99.00 abdominal pain 6 98.12 palliative 47 97.32 fibrosis 79 95.76

Disease Link Frequency Relevance Heat Advanced Or Metastatic Breast Cancer 27 99.84 Breast Cancer 1414 99.76 Metastasis 481 99.74 INFLAMMATION 156 99.72 Osteoarthritis 24 99.64 Rhinitis 17 99.60 Cv General 4 Under Development 1 99.56 Necrosis 17 99.46 Pneumonia 3 99.46 Injury 50 99.42

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As shown in Table 3, tumor size, age categories and PAI-1 mRNA expression are of prognostic value for MFS while lymph node status, histological type, histological grade and uPA expression did not add significant independent prognostic information.

Gene_expression (expression) of uPA in lymph node associated with cancer

1) Confidence 0.76 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.89 Pain Relevance 0

More recently, Castello et al. [31] developed a quantitative real-time RT-PCR assay and showed that uPA and PAI-1 mRNA expression increased with tumor severity in breast cancer, thereby confirming previous results obtained by Northern blotting [32].

Gene_expression (expression) of uPA associated with cancer and breast cancer

2) Confidence 0.76 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.67 Pain Relevance 0

Moreover, it has been demonstrated that high uPA and PAI-1 mRNA expression was significantly associated with shorter disease-free survival in a population of 130 primary breast cancers independent of the hormone receptor and the lymph node status [33].

Gene_expression (expression) of uPA in lymph node associated with breast cancer and disease

3) Confidence 0.76 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.76 Pain Relevance 0

The independent relationship of uPA and PAI-1 gene expression with MFS was also studied using Cox-multivariate regression analysis.

Gene_expression (expression) of uPA

4) Confidence 0.76 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.46 Pain Relevance 0

Interestingly, uPA and PAI-1 mRNA expression may also be considered as significant prognostic factors with strong p-values (p = 0.0005 and p < 0.0001 respectively).

Gene_expression (expression) of uPA

5) Confidence 0.76 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.59 Pain Relevance 0

Celecoxib caused phosphorylation of eukaryotic translation initiation factor 2 kinase (PERK) and eukaryotic initiation factor-2alpha (eIF2alpha) and production of activating transcription factor (ATF)4 mRNA.

Gene_expression (production) of ATF

6) Confidence 0.75 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.76 Pain Relevance 0.44

The expression level of uPA mRNA and the amount of uPA antigen increased significantly on treatment with each concentration of IL-1beta (1 and 10 ng/ml) and 10 ng/ml TNF-alpha.

Gene_expression (expression) of uPA mRNA

7) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.52 Pain Relevance 0.09

In acute inflammatory condition, little is known about the expression of the urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in the gastric fibroblasts.

Gene_expression (expression) of uPA in fibroblasts associated with inflammation

8) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.52 Pain Relevance 0.10

The effect of indomethacin on uPA and uPAR expression in these cells was also examined.

Gene_expression (expression) of uPA

9) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.49 Pain Relevance 0.10

To clarify the role of human gastric fibroblasts in acute inflammatory conditions such as gastric ulcer, the effects of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha on the expression of uPA and uPAR, which were suggested to be associated with tissue remodeling, in gastric fibroblasts were investigated.

Gene_expression (expression) of uPA in fibroblasts associated with necrosis, inflammation, cancer and peptic ulcer

10) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.56 Pain Relevance 0.09

Furthermore, we investigated the role of prostaglandin E2 (PGE2), which is suggested to play major roles in acute inflammation of the stomatch, on uPA and uPAR expression in gastric fibroblasts.

Gene_expression (expression) of uPA in fibroblasts associated with inflammation

11) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.28 Pain Relevance 0.12

When gastric fibroblasts were treated with 50 microM indomethacin, the expression level of uPA mRNA decreased significantly, and the amount of uPA antigen in the culture medium and on cell surfaces decreased significantly with indomethacin in a dose-dependent manner.

Gene_expression (expression) of uPA mRNA in fibroblasts

12) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.48 Pain Relevance 0.10

These results suggest that uPA and uPAR expression in gastric fibroblasts is involved in the regulating system of PGE2 and that NSAIDs may delay healing of gastric mucosal injury in part through suppressing uPA production via inhibition of endogenous PG production.

Gene_expression (expression) of uPA in PGE2 associated with injury and cinod

13) Confidence 0.75 Published 2003 Journal Dig. Dis. Sci. Section Abstract Doc Link 14714609 Disease Relevance 0.26 Pain Relevance 0.14

Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans.

Gene_expression (expression) of urokinase plasminogen in knee associated with inflammation, cinod and osteoarthritis

14) Confidence 0.73 Published 2008 Journal Clin. Biochem. Section Title Doc Link 17996201 Disease Relevance 0.29 Pain Relevance 0.46

OBJECTIVES: The purpose of this study was to examine the ex vivo effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the expression of urokinase-type plasminogen activator (u-PA), PA inhibitor-1 (PAI-1) and gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] in the early knee osteoarthritis (OA) of humans.

Spec (examine) Gene_expression (expression) of u-PA in knee associated with inflammation, knee osteoarthritis, metalloproteinase, cinod and osteoarthritis

15) Confidence 0.73 Published 2008 Journal Clin. Biochem. Section Abstract Doc Link 17996201 Disease Relevance 0.35 Pain Relevance 0.47

The CSF concentrations of uPA and MMP-9 were evaluated in 30 EOMA patients and 10 controls.

Gene_expression (concentrations) of uPA in EOMA

16) Confidence 0.71 Published 2010 Journal Cytokine Section Abstract Doc Link 20584616 Disease Relevance 0.48 Pain Relevance 0.16

The suppressive action of the two drugs on the synthesis of uPA, while stimulating PAI-1 production, may have a positive impact on the balance of plasminogen activator/inhibitor, which could help reduce cartilage catabolism.

Gene_expression (synthesis) of uPA in cartilage

17) Confidence 0.70 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9272300 Disease Relevance 0.08 Pain Relevance 0

OBJECTIVES: To evaluate the effect of therapeutic and pharmacologic concentrations of two non-steroidal anti-inflammatory drugs (NSAIDs), nimesulide and naproxen, on the synthesis of urokinase (uPA), plasminogen activator inhibitor (PAI-1) and interleukin-6 (IL-6) in human synovial fibroblasts isolated from osteoarthritis (OA) patients.

Gene_expression (synthesis) of uPA in fibroblasts associated with inflammation, cinod and osteoarthritis

18) Confidence 0.70 Published 1997 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 9272300 Disease Relevance 0.19 Pain Relevance 0.32

METHODS: Urokinase, PAI-1, and IL-6 production were measured by specific ELISA.

Gene_expression (production) of Urokinase

19) Confidence 0.70 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9272300 Disease Relevance 0.10 Pain Relevance 0

Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.

Gene_expression (synthesis) of urokinase in fibroblasts associated with cinod

20) Confidence 0.70 Published 1997 Journal Clin. Exp. Rheumatol. Section Title Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0.33

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