INT11360

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Context Info
Confidence 0.80
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 33.98
Pain Relevance 5.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
platelet 4
Adipocytes 3
blood 2
endothelial cells 2
endothelium 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 138 100.00 Very High Very High Very High
rheumatoid arthritis 13 99.76 Very High Very High Very High
Osteoarthritis 56 99.22 Very High Very High Very High
bradykinin 19 98.84 Very High Very High Very High
agonist 96 98.24 Very High Very High Very High
Inflammation 640 98.16 Very High Very High Very High
ischemia 10 96.56 Very High Very High Very High
depression 84 95.56 Very High Very High Very High
Pain 37 95.36 Very High Very High Very High
Inflammatory mediators 44 94.48 High High
Disease Link Frequency Relevance Heat
Cancer 446 100.00 Very High Very High Very High
Necrosis 39 100.00 Very High Very High Very High
Adhesions 77 99.76 Very High Very High Very High
Rheumatoid Arthritis 16 99.76 Very High Very High Very High
Obesity 480 99.74 Very High Very High Very High
Osteoarthritis 9 99.22 Very High Very High Very High
Sprains And Strains 169 99.20 Very High Very High Very High
Malignant Neoplastic Disease 32 99.10 Very High Very High Very High
Pre-eclampsia 28 99.02 Very High Very High Very High
Increased Venous Pressure Under Development 331 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies focused on messengers of the components of the plasminogen activation system in human breast cancer by mainly comparing normal, benign and malignant breast tissues or by examining the cellular localization of uPA and PAI-1 [25-30].
Localization (localization) of PAI-1 associated with malignant neoplastic disease and breast cancer
1) Confidence 0.80 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.69 Pain Relevance 0
However, there was no significant increase in PAI-1 antigen secreted into the culture medium after PMA (100-300 nM) treatment.
Localization (secreted) of PAI-1
2) Confidence 0.79 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.20 Pain Relevance 0.26
Plasminogen activator inhibitor-1 (PAI-1), secreted by vascular cells, is the primary physiological inhibitor of plasminogen activation in blood, contributing to thrombus formation [23].
Localization (secreted) of PAI-1 in blood associated with thrombosis
3) Confidence 0.76 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 1.45 Pain Relevance 0.15
Thus, dysfunctional vascular endothelium, characterizing preeclampsia resulting to IUGR, is associated with increased PAI-1 release [54].
Localization (release) of PAI-1 in vascular endothelium associated with pre-eclampsia
4) Confidence 0.76 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 0.52 Pain Relevance 0.04
Plasminogen activator inhibitor-1 (PAI-1), secreted by vascular cells, is the primary physiological inhibitor of plasminogen activation in blood, contributing to thrombus formation [23].
Localization (secreted) of Plasminogen activator inhibitor-1 in blood associated with thrombosis
5) Confidence 0.76 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 1.52 Pain Relevance 0.15
Cyclic AMP agonists forskolin, Sp-cAMP, and IBMX mimic the effects of the PGEs. rhIL-1 beta stimulated the secretion of PAI-1 in a dose-dependent fashion under basal culture conditions; the effect was reversed by actinomycin D and the protein kinase inhibitors H7 and staurosporine but not KT-5720.
Localization (secretion) of PAI-1 associated with agonist
6) Confidence 0.74 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.25 Pain Relevance 0.22
The cag PAI encodes a type IV secretion system, by which CagA proteins are delivered into host cells [26–30].
Localization (secretion) of PAI
7) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.13 Pain Relevance 0
Unfortunately, immunohistochemical assays of the uPA/PAI-1 system have provided unsatisfactory results mainly due to an absence of consensus regarding uPA and PAI-1 cellular localization [24].
Localization (localization) of PAI-1
8) Confidence 0.70 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.58 Pain Relevance 0
PGE2 (and PGE1) inhibited PAI-1 mRNA expression and secretion in a dose-dependent manner with an IC50 (for antigen secretion) of 4.6 x 10(-10) M and 8.7 x 10(-10) M, respectively.
Localization (secretion) of PAI-1 mRNA
9) Confidence 0.69 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.28 Pain Relevance 0.22
Tiaprofenic acid also exerted a suppressive effect on the synthesis of PAI-1 in both OA and RA synovial membranes, and on the release of PAI-2 in RA synovium.
Localization (release) of PAI in synovium associated with rheumatoid arthritis and osteoarthritis
10) Confidence 0.69 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 1.21 Pain Relevance 0.55
Both the secreted FN1 and PAI1 functions to enhance cell attachment and normal cell growth [20].
Localization (secreted) of PAI1
11) Confidence 0.67 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0
We also report that the cagPAI was acquired by native Peruvian strains probably from a European source.
Localization (acquired) of cagPAI associated with sprains and strains
12) Confidence 0.59 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553449 Disease Relevance 0.80 Pain Relevance 0
Adipose tissue is now regarded as an endocrine organ and secretes several adipokines, such as adiponectin, resistin, plasminogen activating inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) [29]–[31].
Localization (secretes) of PAI-1 in endocrine organ associated with obesity
13) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.36 Pain Relevance 0.36
On PAI-1 secretion, rofecoxib in synovial cultures and diclofenac, nimesulide, celecoxib and etoricoxib in chondral and synovial cultures had significantly suppressive effects at 48 h.
Localization (secretion) of PAI-1
14) Confidence 0.55 Published 2008 Journal Clin. Biochem. Section Body Doc Link 17996201 Disease Relevance 0.07 Pain Relevance 0
Adipocytes are metabolically active cells which secrete tumor necrosis factor alpha, interleukin 6, plasminogen activator inhibitor-1, leptin, resistin, adiponectin, and angiotensinogen (Rondinone 2006; Yu and Ginsberg 2005).
Localization (secrete) of plasminogen activator in Adipocytes associated with necrosis, cancer and obesity
15) Confidence 0.55 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.60 Pain Relevance 0
For these analyses, natural log-transformations were performed to approximate normality of CRP, IL-6, adiponectin, resistin, PAI-1 and RBP4, as they were not normally distributed.
Localization (normality) of PAI-1
16) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 1.20 Pain Relevance 0.20
Another reason is that some of these adipokines are not exclusively secreted by adipose tissues and could be secreted by other organs (for example, resistin could be produced in peripheral blood monocytes [50], PAI-1 and RBP4 could be synthesized in the liver, [29], [51]).


Localization (secreted) of PAI-1 in monocytes
17) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148106 Disease Relevance 0.96 Pain Relevance 0.17
Samples were scored for abundance of immunoreactivity in superficial chondrocytes (TIMP-1, TIMP-3 and SLPI), or for the depth to which immunoreactive chondrocytes were localised in articular cartilage (PAI-1 and VEGF).
Localization (localised) of PAI-1 in articular cartilage
18) Confidence 0.41 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2877870 Disease Relevance 0.40 Pain Relevance 0.10
Adipocytes express and secrete a variety of adipokines including cytokines, growth factors, adiponectin, resistin, adipsin, leptin, acylation stimulating protein, plasminogen activator inhibitor-1 (PAI-1), lipoprotein lipase, and components of the renin-angiotensin system which may exert local (autocrine/paracrine) and systemic (endocrine) effects [67–69].

5.2.

Localization (secrete) of PAI-1 in Adipocytes associated with obesity and cytokine
19) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.51 Pain Relevance 0.13
Adipocytes express and secrete a variety of adipokines including cytokines, growth factors, adiponectin, resistin, adipsin, leptin, acylation stimulating protein, plasminogen activator inhibitor-1 (PAI-1), lipoprotein lipase, and components of the renin-angiotensin system which may exert local (autocrine/paracrine) and systemic (endocrine) effects [67–69].

5.2.

Localization (secrete) of activator inhibitor-1 in Adipocytes associated with obesity and cytokine
20) Confidence 0.22 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.50 Pain Relevance 0.13

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