INT113602

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 48
Total Number 48
Disease Relevance 48.71
Pain Relevance 17.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl2) extracellular region (Ccl2) cytoskeleton organization (Ccl2)
cytoplasm (Ccl2)
Anatomy Link Frequency
monocyte 11
astrocytes 9
macrophage 7
brain 6
aorta 4
Ccl2 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1110 100.00 Very High Very High Very High
Inflammation 1105 100.00 Very High Very High Very High
cytokine 372 100.00 Very High Very High Very High
Inflammatory mediators 26 100.00 Very High Very High Very High
metalloproteinase 19 100.00 Very High Very High Very High
Pain 33 99.90 Very High Very High Very High
Central nervous system 784 99.80 Very High Very High Very High
Neuropathic pain 13 99.78 Very High Very High Very High
b2 receptor 17 99.70 Very High Very High Very High
Paracetamol 18 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1219 100.00 Very High Very High Very High
Multiple Sclerosis 1076 100.00 Very High Very High Very High
Cancer 359 100.00 Very High Very High Very High
Necrosis 97 100.00 Very High Very High Very High
Diabetes Mellitus 121 99.98 Very High Very High Very High
Glioblastoma 198 99.86 Very High Very High Very High
Central Nervous System Disease 630 99.80 Very High Very High Very High
Neuropathic Pain 40 99.78 Very High Very High Very High
Atherosclerosis 73 99.74 Very High Very High Very High
Cv General 4 Under Development 15 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CCL2 in astrocytes associated with nociception and chemokine
1) Confidence 0.70 Published 2007 Journal Neuroscience Section Title Doc Link 17870246 Disease Relevance 0.88 Pain Relevance 0.89
In mice, the increased expression of MCP-1 (CCL2) by CNS immune cells is closely associated with the clinical activity of EAE [12-14].
Positive_regulation (increased) of Gene_expression (expression) of CCL2 in immune cells associated with multiple sclerosis and central nervous system
2) Confidence 0.67 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.06 Pain Relevance 0.42
In concert with the mouse data [4,13], not only higher numbers of macrophages infiltrated the spinal cord during the first and second attacks of CR-EAE as compared to those at the peak of acute EAE in these rats, but the expression of MCP-1 (CCL2) was also significantly higher in the lesion of CR-EAE as compared to that of acute EAE.
Positive_regulation (higher) of Gene_expression (expression) of MCP-1 in spinal cord associated with multiple sclerosis and spinal cord
3) Confidence 0.67 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.71 Pain Relevance 0.15
Some studies, however, suggest that the presence of leukocytes is necessary for the production of CCL2 by astrocytes, as the expression of CCL2 prior to the accumulation of inflammatory mononuclear cells has not been observed in the CNS.
Positive_regulation (necessary) of in astrocytes Gene_expression (production) of CCL2 in mononuclear cells associated with inflammation and central nervous system
4) Confidence 0.67 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.24 Pain Relevance 0.38
In the present study, we assess nociceptive responses of mice that overexpressed CCL2 under control of glial fibrillary acidic protein promoter (CCL2 tg).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CCL2 associated with nociception
5) Confidence 0.61 Published 2007 Journal Neuroscience Section Abstract Doc Link 17870246 Disease Relevance 0.58 Pain Relevance 0.39
Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of chemokine ligand 2 in astrocytes associated with nociception and chemokine
6) Confidence 0.50 Published 2007 Journal Neuroscience Section Title Doc Link 17870246 Disease Relevance 0.87 Pain Relevance 0.88
In mice, the increased expression of MCP-1 (CCL2) by CNS immune cells is closely associated with the clinical activity of EAE [12-14].
Positive_regulation (increased) of Gene_expression (expression) of MCP-1 in immune cells associated with multiple sclerosis and central nervous system
7) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.06 Pain Relevance 0.42
In concert with the mouse data [4,13], not only higher numbers of macrophages infiltrated the spinal cord during the first and second attacks of CR-EAE as compared to those at the peak of acute EAE in these rats, but the expression of MCP-1 (CCL2) was also significantly higher in the lesion of CR-EAE as compared to that of acute EAE.
Positive_regulation (peak) of Gene_expression (expression) of CCL2 in spinal cord associated with multiple sclerosis and spinal cord
8) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.77 Pain Relevance 0.18
We detected an increased expression of CCL2 in plaques as compared to NAWMs, and an increased expression of CCL7 in both plaques and NAWMs as compared to NAGMs.
Positive_regulation (increased) of Gene_expression (expression) of CCL2 in plaques
9) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.45 Pain Relevance 0.27
Some studies, however, suggest that the presence of leukocytes is necessary for the production of CCL2 by astrocytes, as the expression of CCL2 prior to the accumulation of inflammatory mononuclear cells has not been observed in the CNS.
Neg (not) Positive_regulation (observed) of Gene_expression (expression) of CCL2 in mononuclear cells associated with inflammation and central nervous system
10) Confidence 0.48 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.35 Pain Relevance 0.38
For example, ccr2 knock-out mice are resistant to the establishment of neuropathic pain, and mice overexpressing its ligand, monocyte chemoattractant protein-1 (MCP1; also known as CCL2), show enhanced pain sensitivity.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of monocyte chemoattractant protein-1 in monocyte associated with targeted disruption, pain and neuropathic pain
11) Confidence 0.48 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 0.74 Pain Relevance 0.65
While high numbers of MNCs expressing CCL2 and CCL5 were found in some patients, overall no differences were observed between MS and acute meningitis.
Positive_regulation (numbers) of Gene_expression (expressing) of CCL2 associated with multiple sclerosis and meningitis
12) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.74 Pain Relevance 0.71
Increased CCL2 expression in the CNS also resulted in a decreased IL-12 receptor expression by PLP-specific T cells.
Positive_regulation (Increased) of Gene_expression (expression) of CCL2 in T cells associated with central nervous system
13) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.79 Pain Relevance 0.31
Thus in this model, the overexpression of CCL2 in the CNS resulted in a suppression of the TH1 response and a milder clinical phenotype of EAE, despite the enhanced effect on monocytes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CCL2 in monocytes associated with multiple sclerosis and central nervous system
14) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.86 Pain Relevance 0.31
LPS injection induced higher CCL2 expression in the brain and markedly enhanced the mononuclear cell (MNC) infiltrate.
Positive_regulation (higher) of Gene_expression (expression) of CCL2 in brain
15) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.34 Pain Relevance 0.27
LPS injection induced higher CCL2 expression in the brain and markedly enhanced the mononuclear cell (MNC) infiltrate.
Positive_regulation (induced) of Gene_expression (expression) of CCL2 in brain
16) Confidence 0.45 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 1.34 Pain Relevance 0.27
19- and 16-fold increase in KC and MCP-1 gene expression, respectively, over WT I/R tissues (data not shown; n=6; P<0.05).


Positive_regulation (increase) of Gene_expression (expression) of MCP-1
17) Confidence 0.45 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.05 Pain Relevance 0.14
For example, ccr2 knock-out mice are resistant to the establishment of neuropathic pain, and mice overexpressing its ligand, monocyte chemoattractant protein-1 (MCP1; also known as CCL2), show enhanced pain sensitivity.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of MCP1 in monocyte associated with targeted disruption, pain and neuropathic pain
18) Confidence 0.45 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19553445 Disease Relevance 0.74 Pain Relevance 0.65
Parallel to these enhanced behavioral responses CCL2 serum levels were significantly greater in CCL2 overexpressing mice and remained elevated 7 days post CFA.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CCL2
19) Confidence 0.44 Published 2007 Journal Neuroscience Section Abstract Doc Link 17870246 Disease Relevance 1.00 Pain Relevance 0.90
Overexpression of TRX-1 also reduced H(2)O(2)-induced MCP-1 production in isolated pancreatic acinar cells.
Positive_regulation (induced) of Gene_expression (production) of MCP-1 in acinar cells
20) Confidence 0.42 Published 2006 Journal Antioxid. Redox Signal. Section Abstract Doc Link 16987036 Disease Relevance 0.81 Pain Relevance 0.57

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