INT113603

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 22.82
Pain Relevance 9.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mcpt1) extracellular region (Mcpt1) intracellular (Mcpt1)
Anatomy Link Frequency
bladders 4
retina 3
adipocytes 3
choroid 3
hippocampus 2
Mcpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 99 100.00 Very High Very High Very High
Hippocampus 41 100.00 Very High Very High Very High
Inflammation 624 99.98 Very High Very High Very High
agonist 130 99.98 Very High Very High Very High
qutenza 16 99.98 Very High Very High Very High
Paracetamol 7 99.82 Very High Very High Very High
antagonist 38 99.62 Very High Very High Very High
cINOD 42 99.48 Very High Very High Very High
ischemia 29 99.24 Very High Very High Very High
bradykinin 32 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 115 100.00 Very High Very High Very High
INFLAMMATION 641 99.98 Very High Very High Very High
Atherosclerosis 105 99.84 Very High Very High Very High
Cv General 4 Under Development 4 99.68 Very High Very High Very High
Hypoxia 66 99.44 Very High Very High Very High
Sprains And Strains 55 99.16 Very High Very High Very High
Multiple Sclerosis 148 98.92 Very High Very High Very High
Obesity 25 98.68 Very High Very High Very High
Targeted Disruption 116 98.44 Very High Very High Very High
Fibrosis 2 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Negative_regulation (inhibited) of Gene_expression (expressions) of MCP-1 in adipocytes associated with qutenza and obesity
1) Confidence 0.41 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.23 Pain Relevance 0.66
In contrast, protein levels of MCP-1 in the RPE-choroid complex were significantly decreased by 31.9% in the EPA-treated animals (353.3±36.2 pg/mg, n=8, p<0.05; Figure 4A).
Negative_regulation (decreased) of Gene_expression (levels) of MCP-1 in choroid
2) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.90 Pain Relevance 0.08
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Negative_regulation (levels) of Gene_expression (production) of MCP-1 in retina
3) Confidence 0.32 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.09 Pain Relevance 0.41
and MCP-1 was detected specifically within the entorhinal cortex and not the hippocampus, despite the fact that immunocytochemically detectable intraneuronal A?
Negative_regulation (despite) of Neg (not) Gene_expression (detected) of MCP-1 in hippocampus associated with hippocampus
4) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 0.62 Pain Relevance 0.20
and MCP-1 transcript levels, coincident temporally with the production of intracellular A?
Negative_regulation (temporally) of Gene_expression (levels) of MCP-1 transcript
5) Confidence 0.27 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 1.35 Pain Relevance 0.58
Strain differences in V2O5-induced inflammatory chemokine (KC, MIP-2, MCP-1) expression
Negative_regulation (chemokine) of Gene_expression (expression) of MCP-1 associated with chemokine, inflammation and sprains and strains
6) Confidence 0.27 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 1.20 Pain Relevance 0.34
Even more, the expression of MCP-1 was reduced while HO-1 was up regulated by B1R antagonism, confirming previous observations from our group that showed a similar expression profile in B1KO mice [27].
Negative_regulation (reduced) of Gene_expression (expression) of MCP-1
7) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.14 Pain Relevance 0.55
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Negative_regulation (reduced) of Gene_expression (expression) of MCP-1 associated with paracetamol
8) Confidence 0.21 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
and transgenic mice, perhaps indicating different roles for blood leukocyte and vessel wall expressed MCP-1 in the low level apoE suppression of atherosclerosis.
Negative_regulation (suppression) of Gene_expression (expressed) of MCP-1 in leukocyte associated with targeted disruption and atherosclerosis
9) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2423484 Disease Relevance 0.59 Pain Relevance 0.07
The lack of MCP-1 expression detected in BALF from weanling mice may be indicative of a general paucity of chemoattractant chemokine production in this age group.
Negative_regulation (lack) of Gene_expression (expression) of MCP-1 associated with chemokine
10) Confidence 0.18 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.86 Pain Relevance 0.09
A similar pattern of MCP-1 expression was observed.
Negative_regulation (pattern) of Gene_expression (expression) of MCP-1
11) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2791214 Disease Relevance 0.52 Pain Relevance 0.63
We previously have observed that B1R deletion increased HO-1 and decreased MCP-1 expression [27].
Negative_regulation (decreased) of Gene_expression (expression) of MCP-1
12) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.43 Pain Relevance 0.45
The normal bladders expressed a basal level of MCP-1 and IL-6 mRNAs but not IFN-?
Negative_regulation (level) of Gene_expression (mRNAs) of MCP-1 in bladders
13) Confidence 0.14 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2989383 Disease Relevance 0.77 Pain Relevance 0.28
Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.
Negative_regulation (inhibited) of in adipose tissues Gene_expression (expressions) of MCP-1 in adipocytes associated with qutenza and obesity
14) Confidence 0.14 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 17719033 Disease Relevance 1.23 Pain Relevance 0.66
For example, treatment with bradykinin receptor antagonists has been shown to reduce production of chemokines, including KC and MCP-1, after intestinal ischemia and reperfusion [15].
Negative_regulation (reduce) of Gene_expression (production) of MCP-1 associated with chemokine, cv general 4 under development, ischemia, antagonist and bradykinin
15) Confidence 0.11 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2596102 Disease Relevance 1.03 Pain Relevance 1.12
Thus, attenuation of leukocyte recruitment by EPA may result in the decreased production levels of IL-6 and MCP-1 in the retina and choroid.
Negative_regulation (levels) of in choroid Gene_expression (production) of MCP-1 in retina
16) Confidence 0.11 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.09 Pain Relevance 0.41
Effects of nano particles on local expression of eotaxin, MCP-1, RANTES, and IL-6 in the presence of antigen
Negative_regulation (local) of Gene_expression (expression) of MCP-1
17) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1242256 Disease Relevance 0.06 Pain Relevance 0.17
BAPTA significantly reduced MCP-1 and IL-6 expression in a concentration-dependent manner while production of TNF-?
Negative_regulation (reduced) of Gene_expression (expression) of MCP-1
18) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.06 Pain Relevance 0.49
Hypoxia was also shown to strongly inhibit production of MCP-1 [32], IL-1?
Negative_regulation (inhibit) of Gene_expression (production) of MCP-1 associated with hypoxia
19) Confidence 0.08 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 1.32 Pain Relevance 0.23
Serum levels of MCP-1 decreased from 233 +/- 17.5 to 187 +/- 13.5 pg/ml before and after LDL-apheresis (P < 0.05).
Negative_regulation (decreased) of Gene_expression (levels) of MCP-1
20) Confidence 0.06 Published 2005 Journal J Clin Apher Section Abstract Doc Link 15880405 Disease Relevance 0.85 Pain Relevance 0.17

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