INT113604

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 9.37
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctgf) cytosol (Ctgf) extracellular space (Ctgf)
extracellular region (Ctgf) Golgi apparatus (Ctgf) proteinaceous extracellular matrix (Ctgf)
Anatomy Link Frequency
lungs 6
fibroblasts 4
skin 4
PSC 2
connective tissue 2
Ctgf (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 472 100.00 Very High Very High Very High
Inflammation 175 99.96 Very High Very High Very High
Paracetamol 7 99.82 Very High Very High Very High
cytokine 61 99.62 Very High Very High Very High
antagonist 19 99.16 Very High Very High Very High
Pain 17 95.96 Very High Very High Very High
metalloproteinase 7 90.48 High High
Inflammatory mediators 8 81.56 Quite High
analgesia 2 77.32 Quite High
Analgesic 2 59.44 Quite High
Disease Link Frequency Relevance Heat
Fibrosis 707 100.00 Very High Very High Very High
INFLAMMATION 209 99.96 Very High Very High Very High
Primary Sclerosing Cholangitis 7 99.84 Very High Very High Very High
Alcoholic Pancreatitis 1 99.12 Very High Very High Very High
Hypersensitivity 1 98.28 Very High Very High Very High
Pain 14 95.96 Very High Very High Very High
Pulmonary Fibrosis 105 94.24 High High
Systemic Sclerosis 156 92.00 High High
Pseudomonas Infection 1 91.52 High High
Clostridium Difficile Infection 1 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The potential therapeutic effects of inhibitors of ethanol metabolism or anti-oxidants in alcoholic pancreatitis may arise in part through their ability to attenuate CCN2 production by PSC.
Negative_regulation (attenuate) of Gene_expression (production) of CCN2 in PSC associated with primary sclerosing cholangitis and alcoholic pancreatitis
1) Confidence 0.58 Published 2009 Journal Growth Factors Section Abstract Doc Link 19280452 Disease Relevance 0.53 Pain Relevance 0.03
We used Ctgf siRNA as a positive control for inhibition of Ctgf and collagen expression.
Negative_regulation (inhibition) of Gene_expression (expression) of Ctgf
2) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
It should be noted that the Ctgf expression in the fibroblasts was not reduced upon SPARC inhibition.
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of Ctgf in fibroblasts
3) Confidence 0.56 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.32 Pain Relevance 0.05
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Negative_regulation (reduced) of Gene_expression (expression) of CTGF associated with paracetamol
4) Confidence 0.41 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
In detail, compared to bleomycin-induced skin and lungs, SPARC siRNA normalized Ctgf expression in both skin and lungs (2.6-fold reduction in both with P = 0.100 and 0.039, respectively).
Negative_regulation (reduction) of Gene_expression (expression) of Ctgf in lungs
5) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.34 Pain Relevance 0.11
The anti-fibrotic effect of SPARC siRNA in vivo was accompanied by an inhibition of Ctgf expression in these same tissues.


Negative_regulation (inhibition) of Gene_expression (expression) of Ctgf associated with fibrosis
6) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888211 Disease Relevance 0.55 Pain Relevance 0.12
These results appear to contradict our previous report of parallel inhibition of SPARC and CTGF expression in human fibroblasts by SPARC siRNA [14].
Negative_regulation (inhibition) of Gene_expression (expression) of CTGF in fibroblasts
7) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.38 Pain Relevance 0.09
pathway [22-25], and inhibition of Ctgf reduced expression of the fibrotic effect of TGF-?
Negative_regulation (inhibition) of Gene_expression (expression) of Ctgf associated with fibrosis
8) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
pathway [22-25], and inhibition of Ctgf reduced expression of the fibrotic effect of TGF-?
Negative_regulation (effect) of Gene_expression (expression) of Ctgf associated with fibrosis
9) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
siRNAs of SPARC and Ctgf ameliorated fibrosis in skin and reduced inflammation in lungs induced by bleomycin
Negative_regulation (reduced) of Gene_expression (siRNAs) of Ctgf in lungs associated with fibrosis and inflammation
10) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.44 Pain Relevance 0.14
pathway [22-25], and inhibition of Ctgf reduced expression of the fibrotic effect of TGF-?
Negative_regulation (reduced) of Gene_expression (expression) of Ctgf associated with fibrosis
11) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.10 Pain Relevance 0
siRNAs of SPARC and Ctgf reduced the collagen contents in bleomycin-induced mouse skin and lung tissues
Negative_regulation (reduced) of Gene_expression (siRNAs) of Ctgf in skin
12) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.51 Pain Relevance 0.14
The reduction in fibrosis seen with the IA HA injections was not reflected in reduced CTGF levels, suggesting alternate mechanisms for the anti-fibrotic effect.
Neg (not) Negative_regulation (reflected) of Gene_expression (levels) of CTGF associated with fibrosis
13) Confidence 0.23 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 1.00 Pain Relevance 0.73
The reduction in fibrosis seen with the IA HA injections was not reflected in reduced CTGF levels, suggesting alternate mechanisms for the anti-fibrotic effect.
Negative_regulation (reduced) of Gene_expression (levels) of CTGF associated with fibrosis
14) Confidence 0.23 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468886 Disease Relevance 1.00 Pain Relevance 0.72
neutralizing antibody completely inhibited CTGF production (Figure 8a and b), indicating that endogenous synthesis of TGF-?
Negative_regulation (inhibited) of Gene_expression (production) of CTGF
15) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.35 Pain Relevance 0
In detail, compared to bleomycin-induced skin and lungs, SPARC siRNA normalized Ctgf expression in both skin and lungs (2.6-fold reduction in both with P = 0.100 and 0.039, respectively).
Negative_regulation (reduction) of in skin Gene_expression (expression) of Ctgf in lungs
16) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.34 Pain Relevance 0.11
siRNAs of SPARC and Ctgf reduced the collagen contents in bleomycin-induced mouse skin and lung tissues
Negative_regulation (reduced) of in lung Gene_expression (siRNAs) of Ctgf in skin
17) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.51 Pain Relevance 0.14
Wiedmaier et al. have shown that Ki16425, a selective antagonist of LPA1/3 receptors (Ohta et al., 2003), inhibits Cyr61 and CTGF expression (Wiedmaier et al., 2008).
Negative_regulation (inhibits) of Gene_expression (expression) of CTGF associated with antagonist
18) Confidence 0.12 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.68 Pain Relevance 0.11
Cytokine or cytokine receptor patterns showed high expression of CCR1, FGFR1, connective tissue growth factor (CTGF), FGF7, and SCYA19 in biopsies from SSC patients.
Negative_regulation (showed) of Gene_expression (expression) of tissue growth factor in connective tissue associated with hypersensitivity and cytokine
19) Confidence 0.04 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.14 Pain Relevance 0.10

General Comments

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