INT113605

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 22.92
Pain Relevance 9.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
macrophages 6
fibroblasts 4
CNS 4
peritoneal macrophages 2
coronary artery 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 456 100.00 Very High Very High Very High
cytokine 284 100.00 Very High Very High Very High
Central nervous system 156 100.00 Very High Very High Very High
COX2 1 100.00 Very High Very High Very High
Paracetamol 7 99.82 Very High Very High Very High
Inflammation 578 99.38 Very High Very High Very High
fibrosis 123 96.40 Very High Very High Very High
agonist 101 96.24 Very High Very High Very High
Inflammatory response 94 96.20 Very High Very High Very High
ischemia 101 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 298 100.00 Very High Very High Very High
Hypothermia 110 99.98 Very High Very High Very High
Neutropenia 2 99.90 Very High Very High Very High
Systemic Sclerosis 201 99.84 Very High Very High Very High
Breast Cancer 18 99.74 Very High Very High Very High
Diabetes Mellitus 88 99.56 Very High Very High Very High
Obesity 921 99.48 Very High Very High Very High
INFLAMMATION 711 99.38 Very High Very High Very High
Alzheimer's Dementia 38 99.32 Very High Very High Very High
Targeted Disruption 69 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that Marimastat efficiently inhibits MMP-9 activity (Figure 6), Mmp9 homozygous null mice (Mmp9?
Negative_regulation (inhibits) of Gene_expression (activity) of MMP-9
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.99 Pain Relevance 0.21
In the present study, we measured the expression of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9, in the sera and culture supernatants of dermal fibroblasts from SSc patients and compared them with serum concentrations of transforming growth factor ?
Negative_regulation (inhibitor) of Gene_expression (expression) of MMP-9 in fibroblasts associated with metalloproteinase and systemic sclerosis
2) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.40 Pain Relevance 0.41
The present results not only reveal clearly that IR-dependent signaling is critical for macrophage recruitment to WAT upon obesity development, they also define at least two potential mechanisms responsible for this phenomenon: increased apoptosis of macrophages and reduced tissue invasion by these cells due to decreased expression of MMP-9.
Negative_regulation (decreased) of Gene_expression (expression) of MMP-9 in macrophage associated with obesity, metalloproteinase and apoptosis
3) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.21 Pain Relevance 0.15
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Negative_regulation (reduced) of Gene_expression (expression) of MMP-9 mRNA associated with paracetamol
4) Confidence 0.35 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.89 Pain Relevance 0.84
Such an increase in MMP-9 production was partially blocked by treatment with cyclosporin A.
Negative_regulation (blocked) of Gene_expression (production) of MMP-9
5) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 1.01 Pain Relevance 0.14
appears to be triggered at least in part by a cyclosporin A (CsA)-sensitive pathway, since 500 ng/ml CsA limited MMP-9 production in SSc fibroblasts stimulated with IL-1?
Negative_regulation (limited) of Gene_expression (production) of MMP-9 in fibroblasts associated with systemic sclerosis
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.13 Pain Relevance 0.21
Regarding evaluation of amyloid deposition and ECM integrity, we measured MMP-9 and CR positivity, CSPG and biglycan levels.
Negative_regulation (measured) of Gene_expression (positivity) of MMP-9 associated with alzheimer's dementia
7) Confidence 0.34 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 0.91 Pain Relevance 0.03
Intriguingly, IR-deficient cells exhibited a dramatic reduction of MMP-9 mRNA expression both in the basal state as well as upon stimulation with palmitate (Figure 6A).
Negative_regulation (reduction) of Gene_expression (expression) of MMP-9 mRNA associated with metalloproteinase
8) Confidence 0.32 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.40 Pain Relevance 0.46
Treatment of animals with PEG minocycline-liposomes significantly reduced the number of CNS-infiltrating leukocytes, and the overall expression of MMP-9 in the CNS.
Negative_regulation (reduced) of Gene_expression (expression) of MMP-9 in CNS associated with metalloproteinase and central nervous system
9) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2613526 Disease Relevance 0.63 Pain Relevance 0.65
There was also a significant suppression of MMP-9 expression and proteolytic activity in splenocytes of treated animals, but not in CNS-infiltrating leukocytes.
Negative_regulation (suppression) of Gene_expression (expression) of MMP-9 in CNS associated with metalloproteinase and central nervous system
10) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2613526 Disease Relevance 0.59 Pain Relevance 0.64
The expression of MMP-9 by splenocytes was significantly reduced in mice treated daily with i.p. injections of minocycline and i.v. injections of PEG minocycline-liposomes every five days compare to splenocytes from animals that received no treatment, i.p. injections of minocycline every five days, and i.v. injections of empty PEG-liposomes every five days, as shown by ELISA (Fig. 4A).
Negative_regulation (reduced) of Gene_expression (expression) of MMP-9 associated with metalloproteinase
11) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613526 Disease Relevance 0.45 Pain Relevance 0.43
To verify the in vivo relevance of this cell-autonomous impairment in MMP-9 expression and activation, we first determined serum MMP-9 concentrations in lean and obese control and IR?
Negative_regulation (determined) of Spec (determined) Gene_expression (concentrations) of MMP-9 associated with obesity and metalloproteinase
12) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.40 Pain Relevance 0.55
Peritoneally elicited macrophages were either left untreated (basal) or were stimulated with palmitate and expression of MMP-9 mRNA was determined.
Spec (determined) Negative_regulation (determined) of Gene_expression (expression) of MMP-9 mRNA in elicited macrophages associated with metalloproteinase
13) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.36 Pain Relevance 0.44
To verify the in vivo relevance of this cell-autonomous impairment in MMP-9 expression and activation, we first determined serum MMP-9 concentrations in lean and obese control and IR?
Negative_regulation (impairment) of Spec (determined) Gene_expression (concentrations) of MMP-9 associated with obesity and metalloproteinase
14) Confidence 0.26 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.45 Pain Relevance 0.56
Jin et al. have reported that loss of claudin-5 signals appears to be ameliorated in CD47 knockout mice and the genetic deletion of CD47 reduces MMP-9 expression [26].
Negative_regulation (reduces) of Gene_expression (expression) of MMP-9 associated with targeted disruption and metalloproteinase
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997776 Disease Relevance 0.48 Pain Relevance 0.40
To verify the in vivo relevance of this cell-autonomous impairment in MMP-9 expression and activation, we first determined serum MMP-9 concentrations in lean and obese control and IR?
Negative_regulation (impairment) of Gene_expression (expression) of MMP-9 associated with obesity and metalloproteinase
16) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.43 Pain Relevance 0.56
Since it has recently been established that MMP-9 (gelatinase B) plays a critical role in inflammatory macrophage migration [25], we assessed MMP-9 expression and activation in macrophages of control- and IR?
Negative_regulation (assessed) of Gene_expression (expression) of MMP-9 in inflammatory macrophage associated with inflammation and metalloproteinase
17) Confidence 0.23 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.46 Pain Relevance 0.37
Once in the tumor, E. coli for instance altered the tumor microenvironment in murine breast tumors by vascular remodeling, focal concentration of tumor associated macrophages and focal expression of MMP-9 and TNF-?
Negative_regulation (remodeling) of Gene_expression (expression) of MMP-9 in macrophages associated with cancer and breast cancer
18) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724709 Disease Relevance 1.58 Pain Relevance 0
neurological recovery by decreasing iNOS, COX2, MMP9 expression, and
Negative_regulation (decreasing) of Gene_expression (expression) of MMP9 associated with cox2
19) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 1.07 Pain Relevance 0.57
An increased propensity for extracellular matrix (ECM) remodeling is suggested by elevated expression of matrix metalloproteinases (Mmp3, Mmp9 and Mmp13), urokinase-type plasminogen activator (Plau) and secreted protease inhibitors (Serpina3g, Serpin2 and Lcn2).
Negative_regulation (inhibitors) of Gene_expression (expression) of Mmp9 in extracellular matrix associated with metalloproteinase
20) Confidence 0.19 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2529338 Disease Relevance 0.43 Pain Relevance 0.12

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