INT113606

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 46
Total Number 48
Disease Relevance 44.00
Pain Relevance 15.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
fibroblasts 12
plasma 4
skin 4
lung 4
macrophages 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 720 100.00 Very High Very High Very High
Inflammation 534 100.00 Very High Very High Very High
cytokine 317 100.00 Very High Very High Very High
Central nervous system 75 100.00 Very High Very High Very High
Inflammatory mediators 27 100.00 Very High Very High Very High
Paracetamol 14 100.00 Very High Very High Very High
cINOD 13 99.98 Very High Very High Very High
fibrosis 485 99.20 Very High Very High Very High
Hippocampus 7 98.92 Very High Very High Very High
rheumatoid arthritis 92 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Systemic Sclerosis 1072 100.00 Very High Very High Very High
INFLAMMATION 626 100.00 Very High Very High Very High
Fibrosis 433 100.00 Very High Very High Very High
Adhesions 123 100.00 Very High Very High Very High
Bacterial Meningitis 4 99.98 Very High Very High Very High
Bronchiolitis Obliterans 1 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 147 99.82 Very High Very High Very High
Atherosclerosis 87 99.74 Very High Very High Very High
Neutropenia 1 99.68 Very High Very High Very High
Cancer 413 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the overexpression of MMP-9 has been reported in various pathologic conditions characterized by excessive fibrosis, including idiopathic pulmonary fibrosis, bronchial asthma, experimental biliary cirrhosis, and chronic pancreatitis [20-23], suggesting that elevated MMP-9 is closely linked to fibrogenic remodeling in target organs.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MMP-9 associated with asthma, fibrosis, cirrhosis, pulmonary fibrosis and chronic pancreatitis
1) Confidence 0.64 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.73 Pain Relevance 0.46
increases the production of MMP-9 in several cell types, possibly through a process requiring protein synthesis that leads to increased statility of MMP-9 mRNA [40,41].
Spec (possibly) Positive_regulation (increases) of Gene_expression (production) of MMP-9
2) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.34 Pain Relevance 0.25
-induced MMP-9 production by SSc fibroblasts.
Positive_regulation (induced) of Gene_expression (production) of MMP-9 in fibroblasts associated with systemic sclerosis
3) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.08 Pain Relevance 0.13
Such an increase in MMP-9 production was partially blocked by treatment with cyclosporin A.
Positive_regulation (increase) of Gene_expression (production) of MMP-9
4) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 1.01 Pain Relevance 0.14
In SSc, several proinflammatory cytokines activate fibroblasts to increase MMP-9 production, as depicted in Fig. 5.
Positive_regulation (increase) of Gene_expression (production) of MMP-9 in fibroblasts associated with systemic sclerosis and cytokine
5) Confidence 0.56 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.61 Pain Relevance 0.49
These findings suggest that the enhanced production of MMP-9 may contribute to fibrogenic remodeling during the progression of skin sclerosis in SSc.



Positive_regulation (enhanced) of Gene_expression (production) of MMP-9 in skin associated with sclerosis and systemic sclerosis
6) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 1.04 Pain Relevance 0.10
Therefore, it remains to be defined whether the elevated expression of MMP-9 relative to that of TIMP-1 in SSc is directly involved in skin fibrosis or merely reflects biological compensation for excessive fibrosis.
Spec (whether) Positive_regulation (elevated) of Gene_expression (expression) of MMP-9 in skin associated with fibrosis and systemic sclerosis
7) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.41 Pain Relevance 0.25
The expression of MMP-9 has been reported to be elevated in the culture medium of alveolar macrophages from patients with idiopathic pulmonary fibrosis or bronchial asthma [20,21,43].
Positive_regulation (elevated) of Gene_expression (expression) of MMP-9 in alveolar macrophages associated with asthma, fibrosis and pulmonary fibrosis
8) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.43 Pain Relevance 0.21
This finding supports earlier reports that overexpression of MMP-9 is closely linked with various diseases characterized by excessive fibrosis [20-23].
Positive_regulation (overexpression) of Gene_expression (overexpression) of MMP-9 associated with fibrosis and disease
9) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.21 Pain Relevance 0.27
The production of MMP-9 by dermal fibroblasts of SSc patients was strongly upregulated by stimulation with IL-1?
Positive_regulation (upregulated) of Gene_expression (production) of MMP-9 in fibroblasts associated with systemic sclerosis
10) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.63 Pain Relevance 0.29
Expression of macrophage chemotactic protein-1 (MCP-1), KC/gro, interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9), and connective tissue growth factor (CTGF), inflammatory mediators known to participate in tissue repair, as well as the anti-inflammatory cytokine, interleukin-10 (IL-10), also increased in the liver following acetaminophen administration.
Positive_regulation (increased) of Gene_expression (Expression) of matrix metalloproteinase-9 in connective tissue associated with paracetamol, inflammatory mediators, inflammation, metalloproteinase and cytokine
11) Confidence 0.42 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 1.11 Pain Relevance 0.83
Acetaminophen-induced expression of MCP-1, IL-1beta, CTGF, and MMP-9 mRNA was also delayed or reduced in TNFR1(-/-) mice relative to wild-type mice.
Positive_regulation (Acetaminophen-induced) of Gene_expression (expression) of MMP-9 mRNA associated with paracetamol
12) Confidence 0.42 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 14550746 Disease Relevance 0.90 Pain Relevance 0.85
If this is the case in SSc patients, MMP-9 may indirectly participate in the fibrotic reaction through the activation of TGF?
Positive_regulation (activation) of Gene_expression (participate) of MMP-9 associated with fibrosis and systemic sclerosis
13) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.48 Pain Relevance 0.24
Moreover, dermal fibroblasts from patients with SSc produced more MMP-9 than those from healthy controls when they were stimulated with IL-1?
Positive_regulation (with) of Gene_expression (produced) of MMP-9 in fibroblasts associated with systemic sclerosis
14) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 1.06 Pain Relevance 0.15
Moreover, dermal fibroblasts from patients with SSc produced more MMP-9 than those from healthy controls when they were stimulated with IL-1?
Positive_regulation (Moreover) of Gene_expression (produced) of MMP-9 in fibroblasts associated with systemic sclerosis
15) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 1.05 Pain Relevance 0.15
The overproduced MMP-9 may induce microvascular damage and leakage of substances that further augment endothelial cell damage or fibroblast activation in SSc.
Positive_regulation (overproduced) of Gene_expression (overproduced) of MMP-9 in endothelial cell associated with systemic sclerosis
16) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.60 Pain Relevance 0.51
NSAIDs caused dose-dependent induction in MMP-9 and -3 activities and expressions in ulcerated gastric tissues along with significant infiltration of inflammatory cells and disruption of gastric mucosal layer.
Positive_regulation (caused) of Gene_expression (expressions) of MMP-9 associated with inflammation and cinod
17) Confidence 0.39 Published 2009 Journal J. Pineal Res. Section Abstract Doc Link 19522738 Disease Relevance 0.76 Pain Relevance 0.72
Plasma levels of MMP-9, a known protease of IGFBP-3, are significantly elevated postoperatively.
Positive_regulation (elevated) of Gene_expression (levels) of MMP-9 in Plasma
18) Confidence 0.39 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.11 Pain Relevance 0.17
This study has shown that SSc fibroblasts produced more MMP-9 after stimulation with IL-1?
Positive_regulation (after) of Gene_expression (produced) of MMP-9 in fibroblasts associated with systemic sclerosis
19) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.19 Pain Relevance 0.15
The increase in MMP-9 production by IL-1?
Positive_regulation (increase) of Gene_expression (production) of MMP-9
20) Confidence 0.37 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.93 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox