INT113607

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Context Info
Confidence 0.48
First Reported 2003
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.82
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pick1) Golgi apparatus (Pick1) enzyme binding (Pick1)
protein complex (Pick1) cytoplasm (Pick1) protein targeting (Pick1)
Anatomy Link Frequency
peripheral nerve 1
Pick1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 5 99.98 Very High Very High Very High
addiction 1 95.20 Very High Very High Very High
Peripheral nerve injury 2 91.28 High High
Lasting pain 2 89.88 High High
ASIC 1 85.52 High High
Neuropathic pain 3 85.16 High High
intrathecal 1 82.96 Quite High
Analgesic 1 82.20 Quite High
Serotonin 1 78.36 Quite High
Pain 2 77.20 Quite High
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 99.52 Very High Very High Very High
Nervous System Injury 2 90.84 High High
Pain 4 89.88 High High
Ganglion Cysts 1 72.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We implicate for the first time a possible role for GRIP, PICK1 and NSF in neuropathic sensitisation from experiments with cell-permeable blocking peptides mimicking their GluR2 interaction motifs and also demonstrate differential changes in expression of these proteins following peripheral nerve injury.
Spec (possible) Positive_regulation (role) of PICK1 in peripheral nerve associated with nervous system injury, neuropathic pain and peripheral nerve injury
1) Confidence 0.48 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14550765 Disease Relevance 0.60 Pain Relevance 0.61
This regulation by PKC requires PICK-1 (protein interacting with C kinase), a PDZ domain-containing protein, which interacts with the ASIC2b C terminus.
Positive_regulation (requires) of PICK-1 associated with kinase c
2) Confidence 0.03 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14976185 Disease Relevance 0.22 Pain Relevance 0.52

General Comments

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