INT11361

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 3
Speculated 2
Reported most in Abstract
Documents 183
Total Number 186
Disease Relevance 136.45
Pain Relevance 27.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
plasma 12
adipose tissue 11
endothelial cells 7
lymph node 6
chondrocyte 5
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1383 100.00 Very High Very High Very High
cytokine 365 100.00 Very High Very High Very High
fibrosis 289 100.00 Very High Very High Very High
cINOD 76 99.80 Very High Very High Very High
Osteoarthritis 242 99.56 Very High Very High Very High
metalloproteinase 92 99.44 Very High Very High Very High
dexamethasone 16 99.42 Very High Very High Very High
tolerance 85 99.30 Very High Very High Very High
rheumatoid arthritis 57 99.28 Very High Very High Very High
Kinase C 89 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1616 100.00 Very High Very High Very High
Obesity 1051 100.00 Very High Very High Very High
Pulmonary Fibrosis 191 100.00 Very High Very High Very High
Coronary Artery Disease 144 99.74 Very High Very High Very High
Arthritis 51 99.68 Very High Very High Very High
Increased Venous Pressure Under Development 414 99.64 Very High Very High Very High
Keloid Scars 42 99.64 Very High Very High Very High
Osteoarthritis 197 99.56 Very High Very High Very High
Depression 274 99.52 Very High Very High Very High
Thrombophilia 56 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAI-1 production by adipose tissue was correlated with those of TNF-alpha (r=0.5, P=0.01) and TGF-beta (r=0. 53, P=0.007).
Gene_expression (production) of PAI-1 in adipose tissue associated with obesity
1) Confidence 0.78 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.94 Pain Relevance 0.08
The link between the production of PAI-1 inducers such as tumor necrosis factor-alpha and transforming growth factor-beta and the production of PAI-1 by adipose tissue was also evaluated.
Gene_expression (production) of PAI-1 in adipose tissue associated with necrosis, cancer and obesity
2) Confidence 0.78 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.91 Pain Relevance 0.09
These results emphasize the role of adipose tissue in determining plasma levels of PAI-1, with a local contribution of TNF-alpha and TGF-beta in PAI-1 production by adipose tissue.
Gene_expression (production) of PAI-1 in adipose tissue associated with obesity
3) Confidence 0.78 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.90 Pain Relevance 0.07
Human adipose tissue has been shown to produce plasminogen activator inhibitor type 1 (PAI-1).
Gene_expression (produce) of PAI-1 in adipose tissue associated with obesity
4) Confidence 0.78 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.65 Pain Relevance 0.06
The aim of this study was to investigate the relation between the production of PAI-1 by adipose tissue, plasma PAI-1 level, and variables related to the insulin resistance state.
Gene_expression (production) of PAI-1 in plasma associated with obesity and insulin resistance
5) Confidence 0.78 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.77 Pain Relevance 0.07
The link between the production of PAI-1 inducers such as tumor necrosis factor-alpha and transforming growth factor-beta and the production of PAI-1 by adipose tissue was also evaluated.
Gene_expression (production) of PAI-1 in adipose tissue associated with necrosis, cancer and obesity
6) Confidence 0.78 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.81 Pain Relevance 0.08
PAI-1 produced ex vivo by human adipose tissue is relevant to PAI-1 blood level.
Gene_expression (produced) of PAI-1 in adipose tissue associated with obesity
7) Confidence 0.78 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Title Doc Link 10323791 Disease Relevance 0.87 Pain Relevance 0.07
As shown in Table 3, tumor size, age categories and PAI-1 mRNA expression are of prognostic value for MFS while lymph node status, histological type, histological grade and uPA expression did not add significant independent prognostic information.
Gene_expression (expression) of PAI-1 mRNA in lymph node associated with cancer
8) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.79 Pain Relevance 0
More recently, Castello et al. [31] developed a quantitative real-time RT-PCR assay and showed that uPA and PAI-1 mRNA expression increased with tumor severity in breast cancer, thereby confirming previous results obtained by Northern blotting [32].
Gene_expression (expression) of PAI-1 mRNA associated with cancer and breast cancer
9) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.67 Pain Relevance 0
Moreover, it has been demonstrated that high uPA and PAI-1 mRNA expression was significantly associated with shorter disease-free survival in a population of 130 primary breast cancers independent of the hormone receptor and the lymph node status [33].
Gene_expression (expression) of PAI-1 mRNA in lymph node associated with breast cancer and disease
10) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.75 Pain Relevance 0
Interestingly, uPA and PAI-1 mRNA expression may also be considered as significant prognostic factors with strong p-values (p = 0.0005 and p < 0.0001 respectively).
Gene_expression (expression) of PAI-1 mRNA
11) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.59 Pain Relevance 0
Similarly, the PAI-1 expression level was not found to be correlated with any of the established clinical and pathological factors.


Gene_expression (expression) of PAI-1
12) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.63 Pain Relevance 0
As shown in Figure 3, MFS was significantly shorter in patients expressing high level of PAI-1 mRNA (p < 0.0001).
Gene_expression (expressing) of PAI-1 mRNA
13) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.41 Pain Relevance 0
The independent relationship of uPA and PAI-1 gene expression with MFS was also studied using Cox-multivariate regression analysis.
Gene_expression (expression) of PAI-1 gene
14) Confidence 0.77 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.46 Pain Relevance 0
Transcriptional regulation of plasminogen activator inhibitor-1 expression in human synovial fibroblasts by prostaglandin E2: mediation by protein kinase A and role of interleukin-1.
Gene_expression (expression) of plasminogen activator in fibroblasts
15) Confidence 0.76 Published 1994 Journal Mol. Cell. Endocrinol. Section Title Doc Link 7525383 Disease Relevance 0.27 Pain Relevance 0.20
PGE2 (and PGE1) inhibited PAI-1 mRNA expression and secretion in a dose-dependent manner with an IC50 (for antigen secretion) of 4.6 x 10(-10) M and 8.7 x 10(-10) M, respectively.
Gene_expression (expression) of PAI-1 mRNA
16) Confidence 0.76 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.28 Pain Relevance 0.22
The NSAID naproxen (30 micrograms/ml) induced the expression of PAI-1 mRNA over basal levels and super-induced the inhibitor's expression above rhIL-1 beta stimulated levels.
Gene_expression (expression) of PAI-1 mRNA associated with cinod
17) Confidence 0.76 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.11 Pain Relevance 0.23
Our objective was to delineate the mechanisms by which PGE2 and IL-1 beta, inflammatory mediators commonly found at sites of inflammation, regulate the expression and synthesis of PAI-1 in human synoviocytes.
Gene_expression (expression) of PAI-1 associated with inflammatory mediators and inflammation
18) Confidence 0.76 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.29 Pain Relevance 0.22
PMA, an activator of protein kinase C, transiently increased (maximum 3 h) the expression of PAI-1 mRNA by approximately 10-fold, especially the 3.2 kb species.
Gene_expression (expression) of PAI-1 mRNA associated with kinase c
19) Confidence 0.76 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.22 Pain Relevance 0.27
Differential expression of PAI-1 in connective tissues has been associated etiologically with some forms of arthritis.
Gene_expression (expression) of PAI-1 in connective tissues associated with arthritis
20) Confidence 0.76 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.27 Pain Relevance 0.16

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