INT11362

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Context Info
Confidence 0.39
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.55
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
synovium 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 6 100.00 Very High Very High Very High
rheumatoid arthritis 5 100.00 Very High Very High Very High
cINOD 4 71.88 Quite High
Inflammation 1 71.40 Quite High
anesthesia 2 68.20 Quite High
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 6 100.00 Very High Very High Very High
Rheumatoid Arthritis 6 100.00 Very High Very High Very High
Hemorrhage 3 92.40 High High
Arthritis 2 88.32 High High
Knee Osteoarthritis 1 73.64 Quite High
Postoperative Hemorrhage 1 73.60 Quite High
INFLAMMATION 3 71.40 Quite High
Pressure Volume 2 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tiaprofenic acid also exerted a suppressive effect on the synthesis of PAI-1 in both OA and RA synovial membranes, and on the release of PAI-2 in RA synovium.
Regulation (effect) of Localization (release) of PAI in synovium associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.39 Published 1992 Journal Br. J. Rheumatol. Section Abstract Doc Link 1555050 Disease Relevance 1.24 Pain Relevance 0.57
On PAI-1 secretion, rofecoxib in synovial cultures and diclofenac, nimesulide, celecoxib and etoricoxib in chondral and synovial cultures had significantly suppressive effects at 48 h.
Regulation (effects) of Localization (secretion) of PAI-1
2) Confidence 0.19 Published 2008 Journal Clin. Biochem. Section Body Doc Link 17996201 Disease Relevance 0.07 Pain Relevance 0
No differences in the t-PA antigen, PAI-1 antigen release, and plasmin inhibition by alpha2-antiplasmin were apparent between the two groups.
Regulation (apparent) of Localization (release) of PAI-1
3) Confidence 0.02 Published 2001 Journal Thromb. Res. Section Abstract Doc Link 11738071 Disease Relevance 0.24 Pain Relevance 0.12

General Comments

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