INT113625

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 9.82
Pain Relevance 14.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
neurons 14
spikes 10
brain 4
internal 4
dentate gyrus 2
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 50 100.00 Very High Very High Very High
Glutamate receptor 17 100.00 Very High Very High Very High
nMDA receptor 142 99.98 Very High Very High Very High
dorsal root ganglion 208 99.84 Very High Very High Very High
qutenza 496 99.80 Very High Very High Very High
Morphine 8 99.76 Very High Very High Very High
imagery 222 99.24 Very High Very High Very High
antagonist 150 99.22 Very High Very High Very High
Action potential 391 99.00 Very High Very High Very High
narcan 6 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Epilepsy 69 100.00 Very High Very High Very High
Hypoxia 270 99.98 Very High Very High Very High
Diabetes Mellitus 157 99.88 Very High Very High Very High
Ganglion Cysts 253 99.84 Very High Very High Very High
Pain 115 97.96 Very High Very High Very High
Cv Unclassified Under Development 67 97.40 Very High Very High Very High
Targeted Disruption 41 97.32 Very High Very High Very High
Reperfusion Injury 4 97.04 Very High Very High Very High
Drug Induced Neurotoxicity 12 93.84 High High
Coronary Artery Disease 51 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The perivascular nerve network expresses a Ca2+ receptor that is activated by high extracellular Ca2+ concentrations and causes vasorelaxation in resistance arteries.
Positive_regulation (activated) of Gene_expression (expresses) of Ca2 in nerve
1) Confidence 0.50 Published 2009 Journal Vascul. Pharmacol. Section Abstract Doc Link 19056515 Disease Relevance 0 Pain Relevance 0.08
Effects of anoxia on ER Ca2+ stores
Positive_regulation (on) of Gene_expression (stores) of Ca2 associated with hypoxia
2) Confidence 0.43 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.59 Pain Relevance 0
The rate of decline of the Ca2+ transient is dominated by the rate of Ca2+ uptake by the SR and, to a lesser extent, sarcolemmal Ca2+ extrusion by the Na+/Ca2+ exchanger (NCX), which contributes ?
Positive_regulation (contributes) of Gene_expression (exchanger) of Ca2
3) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.74 Pain Relevance 0
In the present study, Gd3+ inhibited both voltage-activated Ca2+ entry and capsaicin-evoked Ca2+ influx, but we could only inhibit capsaicin-evoked Ca2+ transients with Gd3+ concentrations of 500 ?
Positive_regulation (activated) of Gene_expression (entry) of Ca2 associated with qutenza
4) Confidence 0.41 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0 Pain Relevance 0.71
Ca2+ transients were reduced to 9?
Positive_regulation (transients) of Gene_expression (transients) of Ca2
5) Confidence 0.41 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.30 Pain Relevance 0
When ADP was applied at a low dose, only a single peak of Ca2+ was observed in a fraction of cells.
Positive_regulation (When) of Gene_expression (applied) of Ca2
6) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.04
Cross-desensitisation of responses elicited by the two nucleotides depicts the fact that the receptors activated by the different nucleotides share the same Ca2+ stores (n=116–186)

Ca2+ oscillations induced by low doses of nucleotides

Positive_regulation (activated) of Gene_expression (oscillations) of Ca2
7) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.08
Cross-desensitisation of responses elicited by the two nucleotides depicts the fact that the receptors activated by the different nucleotides share the same Ca2+ stores (n=116–186)

Ca2+ oscillations induced by low doses of nucleotides

Positive_regulation (activated) of Gene_expression (oscillations) of Ca2
8) Confidence 0.40 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.08
Western blotting showed that diabetic rats had a reduced expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)2a, with no difference in expression of the Na+/Ca2+ exchanger.
Positive_regulation (had) of Gene_expression (expression) of Ca2 in reticulum associated with diabetes mellitus
9) Confidence 0.39 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 1.00 Pain Relevance 0.08
In any case, the SCN Ca2+ spikes all were not an intrinsic spontaneous activity but induced.


Neg (not) Positive_regulation (induced) of Gene_expression (spikes) of Ca2 in spikes
10) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.20
The observed Ca2+ spikes could be a natural response of SCN neurons trying to recover their original cytosolic [Ca2+]c levels.
Positive_regulation (response) of Gene_expression (spikes) of Ca2 in spikes
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.38
For the majority of the cells (48.7%, 37 out of 76 cells in 3 slices), the amplitude as well as the frequency of Ca2+ spikes were an increasing function of fluo-4 AM concentration (Fig. 5A and B; Frequency: F5,105?
Positive_regulation (increasing) of Gene_expression (spikes) of Ca2 in spikes
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.07
Taken all together, we could conclude that the observed spontaneous SCN Ca2+ spikes were not intrinsic to SCN but induced by fluo-4 dye loading.
Neg (not) Positive_regulation (induced) of Gene_expression (spikes) of Ca2 in spikes
13) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.15
Also, more recently, Irwin and Allen [20] demonstrated that the Ca2+ influx through L-type Ca2+ channels following the electrical stimulation of retinohypothalamic tracts could induce Ca2+ spikes in SCN neurons.
Positive_regulation (induce) of Gene_expression (spikes) of Ca2 in neurons
14) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.28
The firing rate of these induced SCN Ca2+ spikes did not show a circadian variation.
Positive_regulation (induced) of Gene_expression (spikes) of Ca2 in spikes
15) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2835761 Disease Relevance 0 Pain Relevance 0.03
Excessive intracellular Na+ accumulation followed by Ca2+ overload in cardiac tissue is one of the important mechanisms leading to ischemia/reperfusion injury.
Positive_regulation (overload) of Gene_expression (overload) of Ca2 associated with reperfusion injury and ischemia
16) Confidence 0.34 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20450906 Disease Relevance 0.63 Pain Relevance 0.26
It was shown that c-Fos expression in the CA1 region, the CA2 and CA3 regions, and the dentate gyrus of the hippocampus was significantly increased by treadmill running and naloxone, a nonselective opioid receptors antagonist, treatment enhanced treadmill exercise-induced increase of hippocampal c-Fos expression.
Positive_regulation (increased) of Gene_expression (expression) of CA2 in dentate gyrus associated with antagonist, narcan, opioid receptor and hippocampus
17) Confidence 0.33 Published 2003 Journal Life Sci. Section Abstract Doc Link 14550853 Disease Relevance 0 Pain Relevance 0.45
Pharmacological properties of the voltage-gated Ca2+ channels
Positive_regulation (gated) of Gene_expression (channels) of Ca2
18) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659773 Disease Relevance 0 Pain Relevance 0.11
M) had only a small effect on the magnitude of the Ca2+ transient, but attenuated profoundly the inward current (peak current was reduced to 24.8% control); similar observations were made in four further experiments with 30 ?
Positive_regulation (effect) of Gene_expression (transient) of Ca2
19) Confidence 0.27 Published 2008 Journal American Journal of Physiology - Renal Physiology Section Body Doc Link PMC2536873 Disease Relevance 0.09 Pain Relevance 0.49
Chronic, but not acute morphine treatment, up-regulates alpha-Ca2+/calmodulin dependent protein kinase II gene expression in rat brain.
Positive_regulation (up-regulates) of Gene_expression (expression) of Ca2 in brain associated with morphine
20) Confidence 0.27 Published 2008 Journal Neurochem. Res. Section Title Doc Link 18408996 Disease Relevance 0.08 Pain Relevance 0.74

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