INT113659

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 8.49
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ABR) plasma membrane (ABR)
Anatomy Link Frequency
liver 3
epithelium 1
kidney 1
ABR (Homo sapiens)
Pain Link Frequency Relevance Heat
GABAergic 46 99.98 Very High Very High Very High
alcohol 32 97.72 Very High Very High Very High
Lamotrigine 6 93.04 High High
anesthesia 5 92.88 High High
antiepileptic Drug 5 92.32 High High
gABA 59 90.28 High High
Glutamate 5 89.96 High High
Migraine 1 85.12 High High
medulla 13 84.88 Quite High
Gabapentin 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Liver Disease 150 100.00 Very High Very High Very High
Stress 182 99.92 Very High Very High Very High
Philadelphia Chromosome 1 98.92 Very High Very High Very High
Nicotine Addiction 70 98.28 Very High Very High Very High
Parkinson's Disease 10 98.20 Very High Very High Very High
Alcohol Addiction 10 97.72 Very High Very High Very High
Hepatotoxicity 20 97.28 Very High Very High Very High
Asthma 4 96.90 Very High Very High Very High
Nash(non-alcoholic Steatohepatitis) 70 96.32 Very High Very High Very High
Cancer 65 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, when using immunohistochemistry for keratin or ubiquitin, MDBs were found in about 70% of ASH cases in contrast to 40% seen in hematoxilin-eosin-stained sections (Ray 1987).Fig. 2MDBs are seen in various human liver diseases.
Gene_expression (found) of MDB in liver associated with liver disease
1) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.07 Pain Relevance 0
The K8/K18 within MDBs exhibit increased ?
Gene_expression (exhibit) of MDB
2) Confidence 0.65 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.09 Pain Relevance 0
However, even in potentially MDB-forming liver diseases, MDBs are found only in a subset of patients, partially (but not completely) depending on the sensitivity of the detection method used.
Neg (not) Gene_expression (found) of MDB in liver associated with liver disease
3) Confidence 0.58 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.06 Pain Relevance 0
NP was not observed in the gentamicin-administered group while ABR was preserved.
Gene_expression (preserved) of ABR
4) Confidence 0.52 Published 2003 Journal Hear. Res. Section Abstract Doc Link 14553899 Disease Relevance 0 Pain Relevance 0.12
For children younger then 42 weeks, postconceptional age an ABR threshold of 40 dB nHL was considered normal.
Gene_expression (threshold) of ABR
5) Confidence 0.44 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2924505 Disease Relevance 0 Pain Relevance 0.09
Inclusion criteria for the selection of these children were: presence of wave I, III and V at 90 dB measurement; infants measured in quiet or calm conditions and (sub)normal ABR thresholds (?
Gene_expression (thresholds) of ABR
6) Confidence 0.44 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2924505 Disease Relevance 0 Pain Relevance 0.09
Moore et al. [20] demonstrated that both of these theoretical principles were involved in ABR maturation.
Gene_expression (maturation) of ABR
7) Confidence 0.44 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2924505 Disease Relevance 0 Pain Relevance 0
MDB conceived of the study, participated in conduct and oversight of the study, performed statistical analysis and assisted in manuscript preparation WS recruited patients, served as blinded observer, maintained the database and drafted the manuscript

Pre-publication history

Gene_expression (assisted) of MDB
8) Confidence 0.16 Published 2004 Journal BMC Gastroenterol Section Body Doc Link PMC343278 Disease Relevance 0.17 Pain Relevance 0
We examined the effects of flunarizine on potassium currents through cardiac channels encoded by the human ether-a-go-go related gene (hERG) stably expressed in CHO cells.
Gene_expression (expressed) of related gene
9) Confidence 0.12 Published 2006 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16495758 Disease Relevance 0.26 Pain Relevance 0.15
The ease of MDB detection makes them attractive morphologic markers.
Gene_expression (detection) of MDB
10) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.49 Pain Relevance 0
On the other hand, autophagy is upregulated during MDB formation in mice and additional stimulation of autophagy attenuates MDB formation in certain conditions.
Gene_expression (formation) of MDB
11) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.30 Pain Relevance 0
Therefore, mitochondrial oxidative stress seems to be involved in MDB formation in mice which is in good concordance to the mitochondrial dysfunction seen both in ASH and NASH patients (Pessayre 2007; Mantena et al. 2008; Zatloukal et al., unpublished data).
Gene_expression (formation) of MDB associated with parkinson's disease, stress and nash(non-alcoholic steatohepatitis)
12) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.76 Pain Relevance 0
Of note, supplementation of S-adenosylmethionine or mitochondrially targeted antioxidants effectively diminishes MDB formation, thereby pointing to a central role of oxidative stress in MDB generation
Gene_expression (generation) of MDB associated with stress
13) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.35 Pain Relevance 0
In patients, MDB formation is usually a chronic process requiring several years of alcohol intoxication or metabolic imbalance, that is, in association with the metabolic syndrome, Wilson disease, other metabolic disorders, and chronic cholestasis.
Gene_expression (formation) of MDB associated with metabolic disorder, hepatolenticular degeneration, metabolic syndrome, gallstones and alcohol
14) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.68 Pain Relevance 0.08
Immunofluorescence or immunohistochemical staining represents a more sensitive method for MDB detection than conventional histological stainings, but is strongly dependent on the antibody used as well as the staining protocol.
Gene_expression (detection) of MDB
15) Confidence 0.09 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.34 Pain Relevance 0
The whole cell patch-clamp recording technique was used to study the effects on I(Kr) channels expressed by the human ether-a-go-go related gene (hERG) stably expressed in human embryo kidney (HEK) 293 cells.
Gene_expression (expressed) of related gene in kidney
16) Confidence 0.09 Published 2005 Journal Epilepsy Res. Section Abstract Doc Link 15716081 Disease Relevance 0.53 Pain Relevance 0.47
However, even in potentially MDB-forming liver diseases, MDBs are found only in a subset of patients, partially (but not completely) depending on the sensitivity of the detection method used.
Neg (not) Gene_expression (found) of MDB in liver associated with liver disease
17) Confidence 0.08 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.07 Pain Relevance 0
Four decades ago, the milestone discovery of Philadelphia chromosome

(a translocation between chromosome 9 and 22, which fuses the Bcr gene and the

Gene_expression (fuses) of Bcr gene associated with philadelphia chromosome
18) Confidence 0.07 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.98 Pain Relevance 0
Based on studies suggesting a role of the airway epithelial GABAergic system in asthma-related mucus overproduction, we hypothesized that cigarette smoking, another disorder associated with increased mucus production, may modulate GABAergic system-related gene expression levels in the airway epithelium.


Gene_expression (expression) of system-related gene in epithelium associated with asthma, nicotine addiction and gabaergic
19) Confidence 0.01 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2988726 Disease Relevance 0.34 Pain Relevance 0.45

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