INT11367

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 9.34
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (MB)
Anatomy Link Frequency
skeletal muscle 2
myocardial cell 1
skeletal muscle cells 1
urine 1
MB (Homo sapiens)
Pain Link Frequency Relevance Heat
Percutaneous transluminal coronary angioplasty 1 98.28 Very High Very High Very High
Angina 41 97.12 Very High Very High Very High
ischemia 27 96.00 Very High Very High Very High
Pain 4 93.68 High High
Inflammation 21 91.80 High High
methadone 1 90.04 High High
cocaine 3 82.48 Quite High
anesthesia 23 80.56 Quite High
halothane 15 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 10 100.00 Very High Very High Very High
Cv Unclassified Under Development 22 99.96 Very High Very High Very High
Acute Renal Failure 2 99.60 Very High Very High Very High
Injury 15 99.28 Very High Very High Very High
Syndrome 24 98.84 Very High Very High Very High
Rhabdomyolysis 26 98.62 Very High Very High Very High
Malignant Hyperthermia 169 97.76 Very High Very High Very High
Cv General 3 Under Development 4 97.12 Very High Very High Very High
Pressure Volume 2 Under Development 1 97.04 Very High Very High Very High
Myocardial Infarction 51 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Myoglobin release appears to be related to infarct size, the highest levels were found in extensive myocardial infarction and less marked elevations in cases of subendocardial infarction and in half of the cases with acute coronary insufficiency.
Localization (release) of Myoglobin associated with cv unclassified under development, infarction and myocardial infarction
1) Confidence 0.78 Published 1988 Journal Arch. Intern. Med. Section Abstract Doc Link 3401097 Disease Relevance 1.04 Pain Relevance 0.06
Atraumatic rhabdomyolysis is a syndrome characterized by injury to skeletal muscle with subsequent release of intracellular contents, that is myoglobin and creatine kinase.
Localization (release) of myoglobin in skeletal muscle associated with syndrome, injury and rhabdomyolysis
2) Confidence 0.75 Published 2008 Journal Eur J Emerg Med Section Abstract Doc Link 18446076 Disease Relevance 1.15 Pain Relevance 0.24
Rhabdomyolysis is a clinical and biochemical syndrome occurring when skeletal muscle cells erupt and result in release of creatine phosphokinase (CPK), lactate dehydrogenase (LDH) and myoglobin into the interstitial space and plasma.
Localization (release) of myoglobin in skeletal muscle cells associated with disorders of creatine metabolism, syndrome and rhabdomyolysis
3) Confidence 0.57 Published 2007 Journal Hum Exp Toxicol Section Abstract Doc Link 17884958 Disease Relevance 1.16 Pain Relevance 0.05
The major significance of skeletal muscle damage is the potential of released myoglobin to cause acute renal failure in the presence of other co-factors such as hypovolemia, acidosis, or ischemia.
Localization (released) of myoglobin in skeletal muscle associated with acute renal failure, acidosis, pressure volume 2 under development and ischemia
4) Confidence 0.22 Published 1998 Journal J. Med. Primatol. Section Abstract Doc Link 10203011 Disease Relevance 1.72 Pain Relevance 0.19
Since the stage-dependent cellular localization of MB2 is accompanied by differential proteolytic processing [20], it may be that MB2 is aberrantly processed and is misdirected onto the surface of infected cells.
Localization (localization) of MB2
5) Confidence 0.20 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.60 Pain Relevance 0
The surface localization of MB2 at the sporozoite stage provides a potential target for an antibody mediated response.
Localization (localization) of MB2
6) Confidence 0.17 Published 2009 Journal Malar J Section Body Doc Link PMC2772840 Disease Relevance 0.06 Pain Relevance 0
Creatine kinase (CK) and creatine kinase-MB (CK-MB)
Localization (Creatine kinase) of kinase-MB
7) Confidence 0.11 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.16 Pain Relevance 0.11
To evaluate myocardial cell damage in relation to spontaneous and exercise-induced ischaemia, release of myoglobin, creatine kinase (CK) and its isoenzyme MB (CK-MB) into the serum was estimated in 10 patients with severe stable angina.
Localization (release) of MB in myocardial cell associated with angina and cv unclassified under development
8) Confidence 0.06 Published 1992 Journal Eur. Heart J. Section Abstract Doc Link 1555615 Disease Relevance 0.44 Pain Relevance 0.17
Rhabdomyolysis refers to the breakdown of skeletal muscle which is associated with excretion of myoglobin in the urine.
Localization (excretion) of myoglobin in urine associated with rhabdomyolysis
9) Confidence 0.06 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1867813 Disease Relevance 1.58 Pain Relevance 0.16
Release of creatine kinase-MB and cardiac specific troponin-I following percutaneous transluminal coronary angioplasty.
Localization (Release) of kinase-MB associated with percutaneous transluminal coronary angioplasty
10) Confidence 0.00 Published 1991 Journal Eur. Heart J. Section Title Doc Link 1860469 Disease Relevance 0.43 Pain Relevance 0.27

General Comments

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