INT113672

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.40
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB1) plasma membrane (ITGB1)
ITGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
Pain 8 73.52 Quite High
cytokine 9 71.52 Quite High
Inflammation 10 64.96 Quite High
dexamethasone 3 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Tendinopathy 18 96.84 Very High Very High Very High
INFLAMMATION 11 64.96 Quite High
Pain 2 57.84 Quite High
Necrosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Pharyngitis 2 5.00 Very Low Very Low Very Low
Aging 2 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Bone Fracture 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of specific genes, shown to be regulated in the cDNA array analysis, were analyzed in the individual samples using real-time PCR. cDNA arrays showed that gene expressions for matrix-metalloproteinase-2 (MMP-2), fibronectin subunit B (FNRB), vascular endothelial growth factor (VEGF), and mitogen-activated protein kinase p38 (MAPKp38) were up-regulated, while matrix-metalloproteinase-3 (MMP-3) and decorin were down-regulated, in tendinosis tissue compared with control tissue.
Positive_regulation (up-regulated) of Gene_expression (expressions) of FNRB associated with metalloproteinase and tendinopathy
1) Confidence 0.49 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 14554207 Disease Relevance 0.67 Pain Relevance 0.40
Surface epitope analysis revealed that T-MPCs were negative for CD14, CD31, CD34, and CD45 expression and positive for CD29, CD44, CD90, and CD105 expression, a characteristic phenotype of BM-MPCs.
Positive_regulation (positive) of Gene_expression (expression) of CD29
2) Confidence 0.17 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2575631 Disease Relevance 0.06 Pain Relevance 0.06
Expressions of specific genes, shown to be regulated in the cDNA array analysis, were analyzed in the individual samples using real-time PCR. cDNA arrays showed that gene expressions for matrix-metalloproteinase-2 (MMP-2), fibronectin subunit B (FNRB), vascular endothelial growth factor (VEGF), and mitogen-activated protein kinase p38 (MAPKp38) were up-regulated, while matrix-metalloproteinase-3 (MMP-3) and decorin were down-regulated, in tendinosis tissue compared with control tissue.
Positive_regulation (up-regulated) of Gene_expression (expressions) of fibronectin subunit B associated with metalloproteinase and tendinopathy
3) Confidence 0.01 Published 2003 Journal J. Orthop. Res. Section Abstract Doc Link 14554207 Disease Relevance 0.67 Pain Relevance 0.40

General Comments

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