INT113676

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Context Info
Confidence 0.72
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 10.81
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NRP1) cytosol (NRP1) signal transduction (NRP1)
extracellular region (NRP1) cell adhesion (NRP1) plasma membrane (NRP1)
Anatomy Link Frequency
lung 4
lower limb 2
TMJ 1
shoulder joint 1
smooth muscle cells 1
NRP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 89 94.08 High High
Inflammatory mediators 4 86.16 High High
Pain 70 85.16 High High
Inflammation 99 84.84 Quite High
potassium channel 1 84.40 Quite High
Calcitonin gene-related peptide 1 82.96 Quite High
addiction 12 78.96 Quite High
rheumatoid arthritis 54 75.00 Quite High
Enkephalin 1 67.92 Quite High
Glutamate receptor 3 61.44 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 91 99.56 Very High Very High Very High
Adult Respiratory Distress Syndrome 84 99.20 Very High Very High Very High
Congenital Anomalies 3 98.08 Very High Very High Very High
Cancer 31 97.56 Very High Very High Very High
Contracture 4 97.40 Very High Very High Very High
Atherosclerosis 58 97.12 Very High Very High Very High
Diabetes Mellitus 85 97.08 Very High Very High Very High
Dementia 2 95.84 Very High Very High Very High
Headache 74 94.08 High High
Disease 124 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that VEGF165b was widely expressed in normal healthy lung tissue but is reduced in ARDS lung.
Gene_expression (expressed) of VEGF165b in lung associated with adult respiratory distress syndrome
1) Confidence 0.72 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Abstract Doc Link PMC2886605 Disease Relevance 0.62 Pain Relevance 0
VEGF121b and VEGF165b were present in whole lung, BAL, and ATII lysate.
Gene_expression (present) of VEGF165b in lung
2) Confidence 0.72 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Abstract Doc Link PMC2886605 Disease Relevance 0.60 Pain Relevance 0
Human Lung cDNA from Clontech was used for multiplication and insertion of the VEGF165 gene (GenBank accession no.
Neg (no) Gene_expression (accession) of VEGF165 in Lung
3) Confidence 0.65 Published 2007 Journal Genomic Med Section Body Doc Link PMC2276892 Disease Relevance 0.33 Pain Relevance 0
VEGF121b and VEGF165b were present in whole lung, BAL, and ATII lysate.
Gene_expression (present) of VEGF165b in lung
4) Confidence 0.63 Published 2010 Journal American Journal of Physiology - Lung Cellular and Molecular Physiology Section Abstract Doc Link PMC2886605 Disease Relevance 0.60 Pain Relevance 0
Our study on short term effects of angiogenic therapy in severe lower limb ischaemia suggests that muscle VEGF165 over-expression might constitute a promising therapeutic approach.
Gene_expression (over-expression) of VEGF165 in lower limb associated with cv unclassified under development
5) Confidence 0.58 Published 2007 Journal Genomic Med Section Body Doc Link PMC2276892 Disease Relevance 0.15 Pain Relevance 0
We designed a single blind study aiming at analysing the possible effect of VEGF165 muscle overexpression on the clinical evolution of the patients diagnosed with lower limb severe chronic ischaemia unresponsive to classical treatment.
Gene_expression (overexpression) of VEGF165 in lower limb associated with cv unclassified under development
6) Confidence 0.58 Published 2007 Journal Genomic Med Section Body Doc Link PMC2276892 Disease Relevance 0.88 Pain Relevance 0.09
Secondarily, declines in sVEGFR1-VEGF complex concentrations followed increases in NRP1 density (Fig. 5A), as NRP1 competed with sVEGFR1 for binding with free VEGF.
Gene_expression (competed) of NRP1
7) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
The latter effects stemmed from an increasing proportion of total NRP1 being used up in formation of unligated VEGFR1-NRP1 complexes with increasing total VEGFR density (Fig. 5E).
Gene_expression (proportion) of NRP1
8) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0.04
At 105 NRP1/EC, almost all (97%) VEGFR1 became part of unligated VEGFR1-NRP1 complexes – a shift that dramatically reduced the availability of VEGFR1 for VEGF165-ligation (Fig. 5B).
Gene_expression (complexes) of NRP1
9) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
NRP1 protein expression in vivo has yet to be documented in literature.
Gene_expression (expression) of NRP1
10) Confidence 0.50 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2663039 Disease Relevance 0 Pain Relevance 0
For example, sema3A has a high affinity for NRP-1 and NRP-1 was expressed highly by the disc cells as well as PLXA3.
Gene_expression (expressed) of NRP-1
11) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.26 Pain Relevance 0
For example, sema3A has a high affinity for NRP-1 and NRP-1 was expressed highly by the disc cells as well as PLXA3.
Gene_expression (expressed) of NRP-1
12) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.26 Pain Relevance 0
Aliqouts of cDNA were subjected to PCR using primers specific for the house-keeping gene GAPDH, as well as sema3A, sema3F, NRP-1, NRP-2, PLXA1, PLXA2, PLXA3, PLXA4 and PGP9.5 (Table 1).
Gene_expression (as) of NRP-1
13) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
NRP-1 was expressed in the healthy AF cells, but not by the NP.
Gene_expression (expressed) of NRP-1
14) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
For example, of the 59 tokens of the transitive present participial adjective alternation, 20 of those tokens fit the pattern NP1-containing NP2, where the semantic relation is that NP2 contains NP1.
Gene_expression (contains) of NP1
15) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527518 Disease Relevance 0 Pain Relevance 0.04
Astonishingly, one family-B receptor, namely the CGRP receptor, requires coexpression with single transmembrane receptor activity-modifying proteins (RAMP1-3) for ligand binding and signal transduction [59].
Gene_expression (coexpression) of transmembrane receptor
16) Confidence 0.08 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0.06 Pain Relevance 0.17
There was no significant difference in the quantity of all se detected in NP1 and NP2 patients groups.
Gene_expression (groups) of NP1
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.58 Pain Relevance 0.06
It should be noted that out of the 9 CRSwNP patients where no se was detected, 1 patient was in NP1, 4 were in NP2 and 4 were NP3 subgroups.
Gene_expression (subgroups) of NP1
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.39 Pain Relevance 0.17
The gene encodes a large transmembrane receptor [13], which has been shown to be expressed in vascular smooth muscle cells in adult human tissues [14].
Gene_expression (expressed) of transmembrane receptor in smooth muscle cells
19) Confidence 0.06 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577928 Disease Relevance 2.01 Pain Relevance 0.85
CONCLUSIONS: Hypoxia may mainly induce the expression of VEGF121 and VEGF165 in synovial fibroblasts to promote inflamed angiogenesis of TMJ.
Gene_expression (expression) of VEGF165 in TMJ
20) Confidence 0.04 Published 2007 Journal J. Oral Pathol. Med. Section Body Doc Link 17448139 Disease Relevance 0.13 Pain Relevance 0

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