INT113684

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.04
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cyp3a23/3a1) endoplasmic reticulum (Cyp3a23/3a1)
Anatomy Link Frequency
liver 2
nucleus 2
Cyp3a23/3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 48 100.00 Very High Very High Very High
fluoxetine 6 99.48 Very High Very High Very High
Nerve growth factor 79 99.34 Very High Very High Very High
Inflammation 11 98.20 Very High Very High Very High
Dorsal horn 23 96.24 Very High Very High Very High
anesthesia 5 92.16 High High
Desipramine 1 91.84 High High
Nortriptyline 1 90.08 High High
Serotonin 1 80.20 Quite High
Potency 1 74.96 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 46 98.56 Very High Very High Very High
INFLAMMATION 14 98.20 Very High Very High Very High
Adverse Drug Reaction 2 97.76 Very High Very High Very High
Infection 22 97.56 Very High Very High Very High
Toxicity 8 96.16 Very High Very High Very High
Urological Neuroanatomy 13 94.76 High High
Adenovirus Infection 14 93.92 High High
Injury 4 91.48 High High
Cancer 2 87.20 High High
Necrosis 1 86.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MI complexation of CYP appeared to contribute significantly to inhibition by FLU, as evidenced by the 21% decrease in apparent microsomal CYP content produced by 50 microM FLU in the presence of NADPH. 3.
Negative_regulation (decrease) of Gene_expression (produced) of CYP associated with fluoxetine
1) Confidence 0.36 Published 2003 Journal Xenobiotica Section Abstract Doc Link 14555335 Disease Relevance 0 Pain Relevance 0.69
At 72 h of FFx, liver tissues were isolated to determine the mRNA and protein expression of CYP isozymes and NADPH-P450 reductase by reverse transcription-polymerase chain reaction and Western immunoblotting, respectively.
Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of CYP in liver
2) Confidence 0.26 Published 2003 Journal Arch. Pharm. Res. Section Abstract Doc Link 14723344 Disease Relevance 0.51 Pain Relevance 0.09
[41,42], which causes it to redistribute from the nucleus to the cytoplasm, preventing it from forming the heterodimer complex with PXR and suppressing CYP expression and function [43].
Negative_regulation (suppressing) of Gene_expression (expression) of CYP in nucleus
3) Confidence 0.13 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.24 Pain Relevance 0.03
In these instances, the activity and expression of CYP is downregulated, leading to ineffective treatment regimens, unexpected adverse reactions and in, some cases, drug-drug interactions [7,8].
Negative_regulation (downregulated) of Gene_expression (expression) of CYP associated with adverse drug reaction
4) Confidence 0.13 Published 2008 Journal Virol J Section Body Doc Link PMC2565663 Disease Relevance 0.53 Pain Relevance 0.08
Saline distention induced Fos expression in NGF-treated rats compared to saline distention induced Fos expression in CYP-treated rats
Negative_regulation (distention) of Gene_expression (expression) of CYP associated with nerve growth factor
5) Confidence 0.08 Published 2007 Journal BMC Physiol Section Body Doc Link PMC2000875 Disease Relevance 0.30 Pain Relevance 0.52
At PN5, there was a trend toward decreased Tie1 expression with DEX and increased Tie1 expression when RA was added to DEX treatment.
Negative_regulation (decreased) of Gene_expression (expression) of DEX associated with rheumatoid arthritis and dexamethasone
6) Confidence 0.01 Published 2009 Journal Respir Res Section Body Doc Link PMC2739515 Disease Relevance 0.46 Pain Relevance 0.29

General Comments

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