INT11370

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Context Info
Confidence 0.28
First Reported 1982
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 5.45
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
follicle 8
plasma 3
gamete 1
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 36 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
dopamine receptor 1 98.88 Very High Very High Very High
agonist 8 98.32 Very High Very High Very High
Clonidine 4 97.88 Very High Very High Very High
opioid receptor 1 96.76 Very High Very High Very High
aspirin 2 96.64 Very High Very High Very High
Morphine 3 96.02 Very High Very High Very High
endometriosis 9 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Male Infertility 8 99.58 Very High Very High Very High
Stress 1 98.74 Very High Very High Very High
Gynecomastia 6 98.28 Very High Very High Very High
Trypanosomiasis 3 97.92 Very High Very High Very High
Reprotox - General 1 2 97.68 Very High Very High Very High
Oligospermia 4 96.56 Very High Very High Very High
Ulcers 2 95.36 Very High Very High Very High
Endometriosis (extended) 32 95.16 Very High Very High Very High
Radiation Sickness 2 94.36 High High
Polycystic Ovary Syndrome 5 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For this purpose, the capability of the opioid antagonist naloxone to increase circulating levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and cortisol was tested in male subjects of different ages.
Positive_regulation (increase) of luteinizing hormone in follicle associated with antagonist, narcan and opioid
1) Confidence 0.28 Published 1989 Journal Horm. Res. Section Abstract Doc Link 2560454 Disease Relevance 0.17 Pain Relevance 0.39
After 24 h preincubation they were incubated for 24 h with medium only (control) or stimulated with bovine luteinizing hormone - LH (100 ng/ml; positive control) or increasing concentrations (10(-8) to 10(-4) M) of acetylsalicylic acid, indomethacin, ibuprofen, naproxen, piroxicam, phenylbutazone, dipyrone or nimesulide.
Positive_regulation (stimulated) of luteinizing hormone - LH associated with aspirin
2) Confidence 0.22 Published 2009 Journal Pol J Vet Sci Section Abstract Doc Link 19886250 Disease Relevance 0.16 Pain Relevance 0.34
The luteinizing hormone (LH) response to metoclopramide (MCP), a dopamine receptor antagonist, and naloxone (NAL), an opioid receptor antagonist, was evaluated in 7 patients with polycystic ovarian disease (PCOD) before and during treatment with purified human urinary follicle-stimulating hormone (hFSH), and in 6 control women during spontaneously ovulating cycles.
Positive_regulation (response) of luteinizing hormone in follicle associated with antagonist, dopamine receptor, narcan, polycystic ovary syndrome and opioid receptor
3) Confidence 0.20 Published 1989 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 2920972 Disease Relevance 0.26 Pain Relevance 0.36
Stress of many kinds (psychological, physical, metabolic) is able to induce endocrine modifications in humans, such as growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), glucagon and cortisol release.
Positive_regulation (induce) of luteinizing hormone associated with stress
4) Confidence 0.16 Published 1988 Journal J. Endocrinol. Invest. Section Abstract Doc Link 3183302 Disease Relevance 0.56 Pain Relevance 0.09
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Positive_regulation (-stimulated) of luteinizing hormone in plasma associated with opioid
5) Confidence 0.15 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
Oocytes at the first meiotic prophase undergo atresia or resume meiosis after activation by an ovulation-inducing luteinizing hormone (LH) surge to form the haploid gamete for fertilization.
Positive_regulation (inducing) of luteinizing hormone in gamete
6) Confidence 0.04 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2764709 Disease Relevance 0.31 Pain Relevance 0
An endogenous opioid peptide (EOP) antagonist (250 mg naloxone), an EOP agonist (300 mg morphine), or a combination of the two was given in Expt 1, 2 and 3 respectively as a single i.v. injection in cows 16-18 h after OE2, i.e. in the negative feedback phase and before the expected onset of an induced luteinizing hormone (LH) surge.
Positive_regulation (induced) of luteinizing hormone associated with antagonist, agonist, narcan, endogenous opioid and morphine
7) Confidence 0.04 Published 1991 Journal Reprod. Fertil. Dev. Section Abstract Doc Link 1792337 Disease Relevance 0 Pain Relevance 0.66
Serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were markedly lower during megestrol therapy compared with pretreatment values.
Positive_regulation (lower) of luteinizing hormone in follicle
8) Confidence 0.04 Published 1986 Journal Semin. Oncol. Section Abstract Doc Link 3099393 Disease Relevance 0.81 Pain Relevance 0.08
In 24 h sampling studies, mean luteinizing hormone (LH) and LH pulse amplitude were increased without a change in LH pulse frequency.
Positive_regulation (increased) of luteinizing hormone
9) Confidence 0.04 Published 1994 Journal Hum. Reprod. Section Abstract Doc Link 7962456 Disease Relevance 0.65 Pain Relevance 0.22
There was a naloxone-induced increase in the adrenocorticotrophic hormone (ACTH), cortisol, and luteinizing hormone (LH) plasma levels, plus a subjective dysphoric effect in both groups.
Positive_regulation (increase) of luteinizing hormone in plasma
10) Confidence 0.03 Published 2000 Journal J Affect Disord Section Body Doc Link 10708814 Disease Relevance 0.08 Pain Relevance 0
OBJECTIVE: To determine if chronic treatment with the long-acting oral opioid antagonist naltrexone can increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in women with secondary amenorrhea.
Positive_regulation (increase) of luteinizing hormone in follicle associated with antagonist, opioid and reprotox - general 1
11) Confidence 0.02 Published 1992 Journal Fertil. Steril. Section Abstract Doc Link 1555686 Disease Relevance 0.32 Pain Relevance 0.15
Sharp increases in levels of plasma follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were noted in five patients.
Positive_regulation (increases) of luteinizing hormone in follicle
12) Confidence 0.02 Published 1982 Journal Arch. Intern. Med. Section Abstract Doc Link 6802094 Disease Relevance 0.40 Pain Relevance 0.17
Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.
Positive_regulation (elevated) of luteinizing hormone in follicle associated with male infertility
13) Confidence 0.02 Published 2000 Journal J. Androl. Section Abstract Doc Link 10819447 Disease Relevance 0.68 Pain Relevance 0.09
Stimulation by naloxone, an opioid antagonist, of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was examined in spring-born crossbred ram lambs raised under natural photoperiod.
Spec (examined) Positive_regulation (Stimulation) of luteinizing hormone in follicle associated with antagonist, narcan and opioid
14) Confidence 0.02 Published 1991 Journal J. Reprod. Fertil. Section Abstract Doc Link 1920278 Disease Relevance 0 Pain Relevance 0.33
Semen analyses showed complete azoospermia in 4 patients, with elevated follicle-stimulating hormone (FSH) in 3 and elevated luteinizing hormone (LH) in 2 of them.
Positive_regulation (elevated) of luteinizing hormone in follicle associated with male infertility
15) Confidence 0.02 Published 2000 Journal J. Androl. Section Abstract Doc Link 10819447 Disease Relevance 0.69 Pain Relevance 0.10
In the present study, we investigated whether trypanosomiasis-induced reproductive disorders were due to pituitary or hypothalamic dysfunction by determining plasma luteinizing hormone (LH) response to gonadotropin-releasing hormone (GnRH) agonist or clonidine in Trypanosoma congolense-infected female goats.
Spec (determining) Positive_regulation (response) of luteinizing hormone in plasma associated with trypanosomiasis, agonist and clonidine
16) Confidence 0.02 Published 1997 Journal Brain Res. Bull. Section Abstract Doc Link 9365802 Disease Relevance 0.27 Pain Relevance 0.43
Serum luteinizing hormone (LH) concentrations for L gilts averaged 0.65 +/- 0.04 ng/ml during the pretreatment period and increased to an average of 1.3 +/- 0.1 ng/ml (p less than 0.05) during the first 60 min after NAL treatment.
Positive_regulation (increased) of Serum luteinizing hormone associated with narcan
17) Confidence 0.01 Published 1986 Journal Biol. Reprod. Section Abstract Doc Link 3828431 Disease Relevance 0.09 Pain Relevance 0.51

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