INT113700

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 30
Total Number 34
Disease Relevance 21.17
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Chuk) nucleus (Chuk) kinase activity (Chuk)
cytoplasm (Chuk)
Anatomy Link Frequency
epithelial cells 1
Chuk (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 862 100.00 Very High Very High Very High
agonist 125 99.80 Very High Very High Very High
metalloproteinase 76 99.36 Very High Very High Very High
cytokine 480 99.12 Very High Very High Very High
ischemia 33 98.94 Very High Very High Very High
antagonist 44 98.84 Very High Very High Very High
chemokine 80 93.60 High High
fibrosis 41 92.48 High High
COX2 22 90.00 High High
cINOD 20 88.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1033 100.00 Very High Very High Very High
Obesity 259 99.80 Very High Very High Very High
Insulin Resistance 122 99.20 Very High Very High Very High
Apoptosis 208 99.16 Very High Very High Very High
Cirrhosis 81 98.96 Very High Very High Very High
Coronary Artery Disease 46 98.94 Very High Very High Very High
Stress 77 98.82 Very High Very High Very High
Coronary Heart Disease 10 96.40 Very High Very High Very High
Cancer 413 96.00 Very High Very High Very High
Necrosis 70 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, enhanced JNK activation in IKK?
Positive_regulation (activation) of IKK
1) Confidence 0.41 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.93 Pain Relevance 0.04
Many of these signaling cascades activate NF-kappaB by activating the IkappaB kinase (IKK) complex a major component of the canonical pathway.
Positive_regulation (activating) of IKK
2) Confidence 0.31 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 1.37 Pain Relevance 0.20
IKK activation occurs primarily through IKK?
Positive_regulation (activation) of IKK
3) Confidence 0.31 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.95 Pain Relevance 0.19
IKK activation occurs primarily through IKK?
Positive_regulation (activation) of IKK
4) Confidence 0.31 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0.95 Pain Relevance 0.19
This result suggests that IKK?
Positive_regulation (suggests) of IKK
5) Confidence 0.29 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.61 Pain Relevance 0.14
Many researchers have discovered various inhibitors that attenuate IKK?
Positive_regulation (attenuate) of IKK
6) Confidence 0.29 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.17 Pain Relevance 0.06
B kinaseß (IKKß); activation of the TAB1-TAB2-TAK1 complex by ubiquitylated TRAF6, also leading to phosphorylation and activation of IKKß, and phosphorylation of I-?
Positive_regulation (activation) of IKK
7) Confidence 0.25 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0 Pain Relevance 0.04
The dissociation of TRIF activates a complex consisting of the kinases IkappaB kinase (IKK)i and TANK-binding kinase (TBK)-1 as well as the scaffolding protein TRAF3 [58], which ultimately leads to the activation of IRF-3 and IRF-7 and the expression of IFN-inducible genes such as those encoding IFN-?
Positive_regulation (consisting) of IkappaB kinase
8) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.24 Pain Relevance 0.09
RIP is recruited to this receptor complex, which in turn can activate the IKK signalosome to activate NF-?
Positive_regulation (activate) of IKK
9) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.56 Pain Relevance 0.16
B activation and also suggest a model in which B14 inhibits activation of the IKK complex by preventing phosphorylation of IKK?
Positive_regulation (activation) of IKK
10) Confidence 0.18 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
IKK activation induces phosphorylation and degradation of I?
Positive_regulation (activation) of IKK
11) Confidence 0.16 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1933437 Disease Relevance 0.40 Pain Relevance 0.08
Here, activation of pro-inflammatory signaling cascades, particularly JNK and IKK, have been shown to inhibit insulin action, although to different, tissue-specific extent [8], [34]–[36].
Positive_regulation (activation) of IKK associated with inflammation
12) Confidence 0.16 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.33 Pain Relevance 0.23
To study the effect of B14 on IKK activity further, the IKK complex was activated by overexpression of either IKK?
Positive_regulation (activated) of IKK
13) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0.12 Pain Relevance 0
Honda and Taniguchi reported that type I IFN induction was mediated trough TLR signaling, which stimulated sequential activation of adaptors and kinases of the IRAK, IKK and TRAF families, and then leading to the activation of IRF5 and IRF7 [44], [45].
Positive_regulation (activation) of IKK
14) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793013 Disease Relevance 0.23 Pain Relevance 0
null MEFs, indicating that B14 was incorporated in the IKK?
Positive_regulation (incorporated) of IKK
15) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
B gene expression by a similar constitutively active IKK?
Positive_regulation (active) of IKK
16) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
(Figure 7A) or by expression of the constitutively active IKK?
Positive_regulation (active) of IKK
17) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
SS/EE mutant (Figure 7B), indicating IKK?
Positive_regulation (indicating) of IKK
18) Confidence 0.12 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2233672 Disease Relevance 0 Pain Relevance 0
Upon activation of the cell following the binding of cytokines and growth factors or by UV or stress, a signal transduction cascade unravels that leads to the activation of the serine-threonine kinases, IKK1 and IKK2.
Positive_regulation (activation) of IKK1 associated with stress and cytokine
19) Confidence 0.09 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.52 Pain Relevance 0.24
A number of kinases, such as AKT and MEK kinases, activate IKK.
Positive_regulation (activate) of IKK
20) Confidence 0.08 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.17 Pain Relevance 0.31

General Comments

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