INT113705

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2011
Negated 21
Speculated 7
Reported most in Body
Documents 228
Total Number 235
Disease Relevance 149.05
Pain Relevance 7.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) Golgi apparatus (Egfr)
endoplasmic reticulum (Egfr) intracellular (Egfr) enzyme binding (Egfr)
Anatomy Link Frequency
GBM 16
lung 9
A549 9
skin 3
pancreas 3
Egfr (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 468 100.00 Very High Very High Very High
Chronic pancreatitis 28 99.84 Very High Very High Very High
qutenza 12 99.80 Very High Very High Very High
adenocard 24 98.60 Very High Very High Very High
cva 88 98.50 Very High Very High Very High
agonist 46 97.92 Very High Very High Very High
Inflammation 112 96.76 Very High Very High Very High
positron emission tomography 328 96.32 Very High Very High Very High
palliative 109 96.04 Very High Very High Very High
unmyelinated 3 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 8369 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 1877 100.00 Very High Very High Very High
Glioblastoma 1486 100.00 Very High Very High Very High
Lung Cancer 784 100.00 Very High Very High Very High
Metastasis 644 100.00 Very High Very High Very High
Pancreatic Cancer 3262 99.96 Very High Very High Very High
Adenocarcinoma 516 99.90 Very High Very High Very High
Targeted Disruption 284 99.88 Very High Very High Very High
Neuroepithelial Neoplasms 549 99.86 Very High Very High Very High
Breast Cancer 365 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the clinical focus of these agents has been on solid tumors with high levels of EGFR expression whose malignant phenotypes are known to be dependent on EGFR signaling, EGFR expression in and of itself may not be a reliable indicator of the potential antitumor activity of either class of agents, as will be discussed later.
Gene_expression (expression) of EGFR associated with malignant neoplastic disease and solid tumor
1) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.36 Pain Relevance 0
Likewise, Ueda et al demonstrated that cytoplasmic EGFR overexpression by immunohistochemistry was associated with higher grade tumors and shorter survival in a study of 76 archived cases of pancreatic ductal carcinoma (Ueda et al 2004).
Gene_expression (overexpression) of EGFR associated with pancreatic ductal carcinoma and cancer
2) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.99 Pain Relevance 0
Similar to a number of other malignancies, EGFR has been shown to be overexpressed in pancreatic cancers (Yamanaka et al 1993; Arteaga 2001; Tobita et al 2003; Grandis and Sok 2004; Marshall 2006).
Gene_expression (overexpressed) of EGFR associated with pancreatic cancer
3) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.71 Pain Relevance 0
Tobita et al studied EGFR expression by immunohistochemistry in 77 cases of invasive ductal adenocarcinoma of the pancreas and found EGFR expression to be significantly associated with metastatic potential (Tobita et al 2003).
Gene_expression (expression) of EGFR in pancreas associated with adenocarcinoma
4) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.89 Pain Relevance 0
The PA.3 study also assessed EGFR expression in 162 tumor samples adequate for immunohistochemical EGFR analysis.
Gene_expression (expression) of EGFR associated with cancer
5) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 1.05 Pain Relevance 0
In the normal pancreas, EGFR expression is limited to ductal cells and the islets of Langerhans (Ueda et al 2004).
Gene_expression (expression) of EGFR in islets of Langerhans
6) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.71 Pain Relevance 0
Although there was no relationship between clinical outcome and EGFR expression by immunohistochemistry, subgroup analysis in the PA.3 study did identify the development of rash as a significant predictor of response, a finding that has been observed in studies evaluating other EGFR inhibitors in other tumor types.
Gene_expression (expression) of EGFR associated with exanthema and cancer
7) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.50 Pain Relevance 0
While the clinical focus of these agents has been on solid tumors with high levels of EGFR expression whose malignant phenotypes are known to be dependent on EGFR signaling, EGFR expression in and of itself may not be a reliable indicator of the potential antitumor activity of either class of agents, as will be discussed later.
Gene_expression (expression) of EGFR associated with malignant neoplastic disease and solid tumor
8) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.36 Pain Relevance 0
Secondary endpoints included PFS, response rate, response duration, toxicity, quality of life (QOL), and correlation of tumor EGFR expression with clinical outcome.
Gene_expression (expression) of EGFR associated with toxicity and cancer
9) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.61 Pain Relevance 0
Of note, EGFR overexpression was not required for enrollment.
Gene_expression (overexpression) of EGFR
10) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.97 Pain Relevance 0
Of these tumors, 86 (53%) were EGFR positive (as defined by at least 10% of cells staining positive) and 76 (47%) were EGFR negative.
Neg (negative) Gene_expression (negative) of EGFR associated with cancer
11) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.94 Pain Relevance 0
Despite the current gaps in our knowledge, the evidence of EGFR overexpression in pancreatic cancer specimens, combined with convincing in vitro data demonstrating the oncogenic potential of EGFR activation, together support a role for EGFR activation in the progression of this malignancy.
Gene_expression (overexpression) of EGFR associated with malignant neoplastic disease and pancreatic cancer
12) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 1.00 Pain Relevance 0
In addition to overexpression of EGFR, autocrine stimulation of the receptor may also play a role in the pathogenesis of pancreatic cancer.
Gene_expression (overexpression) of EGFR associated with pancreatic cancer
13) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.99 Pain Relevance 0
EGFR overexpression with resultant increase in EGFR signaling may be associated with metastatic potential and decreased survival in patients with pancreatic cancer.
Gene_expression (overexpression) of EGFR associated with pancreatic cancer
14) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.81 Pain Relevance 0
Tobita et al studied EGFR expression by immunohistochemistry in 77 cases of invasive ductal adenocarcinoma of the pancreas and found EGFR expression to be significantly associated with metastatic potential (Tobita et al 2003).
Gene_expression (expression) of EGFR in pancreas associated with adenocarcinoma
15) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.90 Pain Relevance 0
At this time, there is no data to support the decision to use EGFR inhibitor therapy based on EGFR expression by IHC alone.
Gene_expression (expression) of EGFR
16) Confidence 0.78 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.59 Pain Relevance 0
Forty-eight hours after transfection, the expression of the EGFR was examined.
Spec (examined) Gene_expression (expression) of EGFR
17) Confidence 0.78 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.37 Pain Relevance 0
A significant decrease in the number of colonies by 63.3% in A549 and 66.8% in SPC-A1 was apparent when the cells were transfected with dsRNA-EGFR.
Gene_expression (transfected) of dsRNA-EGFR in A549
18) Confidence 0.78 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.38 Pain Relevance 0
Cell count results showed a significant decrease in the number of cells by 85.0% in A549 and 78.3% in SPC-A1 (P < 0.001) (Fig 2A) when transfected with dsRNA-EGFR.
Gene_expression (transfected) of dsRNA-EGFR in A549
19) Confidence 0.78 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.26 Pain Relevance 0
In an effort to develop new strategies to block the over expression of EGFR in NSCLC cells, we examined the potential of a dsRNA-mediated specific RNAi approach for silencing the EGFR in NSCLC cell lines in vitro and in vivo.
Gene_expression (expression) of EGFR associated with non-small-cell lung cancer
20) Confidence 0.78 Published 2005 Journal Genet Vaccines Ther Section Body Doc Link PMC1187910 Disease Relevance 0.54 Pain Relevance 0

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