INT11371

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 1.40
Pain Relevance 2.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (LHB) small molecule metabolic process (LHB) extracellular region (LHB)
cellular nitrogen compound metabolic process (LHB) cell-cell signaling (LHB)
Anatomy Link Frequency
plasma 3
follicle 3
gonadal 2
LHB (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 6 100.00 Very High Very High Very High
narcan 30 99.98 Very High Very High Very High
antagonist 16 99.68 Very High Very High Very High
Endogenous opioid 7 99.64 Very High Very High Very High
Neurotransmitter 4 99.60 Very High Very High Very High
opiate 5 99.44 Very High Very High Very High
Dopamine 2 99.42 Very High Very High Very High
Serotonin 4 99.08 Very High Very High Very High
agonist 2 85.52 High High
endometriosis 1 70.24 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 1 3 99.84 Very High Very High Very High
Galactorrhea 3 99.40 Very High Very High Very High
Anovulation 2 91.12 High High
Reprotox - General 2 3 89.04 High High
Polycystic Ovary Syndrome 1 75.00 Quite High
Eating Disorder 1 75.00 Quite High
Breast Cancer 1 74.56 Quite High
Uterine Fibroids 1 73.28 Quite High
Precocious Puberty 1 71.84 Quite High
Reprotox - General 3 5 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin but not dopamine is involved in the naloxone-induced luteinizing hormone release in man.
Positive_regulation (induced) of Localization (release) of luteinizing hormone associated with dopamine, narcan and serotonin
1) Confidence 0.47 Published 1985 Journal Fertil. Steril. Section Title Doc Link 3979585 Disease Relevance 0 Pain Relevance 0.67
Opiate antagonists can indirectly stimulate the secretion of luteinizing hormone (LH) and testosterone, as well as sexual functions in animals and humans.
Positive_regulation (stimulate) of Localization (secretion) of luteinizing hormone associated with antagonist and opiate
2) Confidence 0.39 Published 1993 Journal J. Androl. Section Abstract Doc Link 8294223 Disease Relevance 0.31 Pain Relevance 0.38
We have investigated whether the stimulatory effect of naloxone on luteinizing hormone (LH) secretion is due to its influence on these neurotransmitters.
Spec (whether) Positive_regulation (influence) of Localization (secretion) of luteinizing hormone associated with neurotransmitter and narcan
3) Confidence 0.34 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 3979585 Disease Relevance 0 Pain Relevance 0.54
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Positive_regulation (-stimulated) of Localization (secretion) of luteinizing hormone in plasma associated with opioid
4) Confidence 0.15 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
The plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) response to acute exercise and the relationship of these opioid peptides to basal and luteinizing hormone-releasing hormone (LRH)-stimulated luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion was studied in eight normal male volunteers.
Positive_regulation (response) of in follicle Localization (secretion) of luteinizing hormone in plasma associated with opioid
5) Confidence 0.15 Published 1986 Journal J. Appl. Physiol. Section Abstract Doc Link 2948941 Disease Relevance 0 Pain Relevance 0.10
OBJECTIVE: To determine if chronic treatment with the long-acting oral opioid antagonist naltrexone can increase luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion in women with secondary amenorrhea.
Positive_regulation (increase) of Localization (secretion) of luteinizing hormone in follicle associated with antagonist, opioid and reprotox - general 1
6) Confidence 0.03 Published 1992 Journal Fertil. Steril. Section Abstract Doc Link 1555686 Disease Relevance 0.32 Pain Relevance 0.15
Role of endogenous opioids in reducing the frequency of pulsatile luteinizing hormone secretion induced by progesterone in normal women.
Positive_regulation (induced) of Localization (secretion) of luteinizing hormone associated with narcan and endogenous opioid
7) Confidence 0.02 Published 1986 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 3652469 Disease Relevance 0 Pain Relevance 0.38
This action leads to the secretion of the gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that in turn act on the reproductive organs regulating gonadal steroid production, spermatogenesis and follicular development.
Positive_regulation (leads) of Localization (secretion) of luteinizing hormone in gonadal
8) Confidence 0.01 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 15544487 Disease Relevance 0.48 Pain Relevance 0.24
Naloxone increases the frequency of pulsatile luteinizing hormone secretion in women with hyperprolactinemia.
Positive_regulation (increases) of Localization (secretion) of luteinizing hormone associated with galactorrhea and narcan
9) Confidence 0.01 Published 1991 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1939525 Disease Relevance 0.28 Pain Relevance 0.37

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