INT113712

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Context Info
Confidence 0.43
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Msh3) nucleus (Msh3) enzyme binding (Msh3)
DNA binding (Msh3)
Anatomy Link Frequency
EM-2 2
Msh3 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 5 100.00 Very High Very High Very High
mu opioid receptor 1 99.84 Very High Very High Very High
analgesia 2 87.92 High High
MU agonist 4 86.48 High High
tail-flick 6 82.96 Quite High
intrathecal 1 76.48 Quite High
Spinal cord 2 75.00 Quite High
Morphine 4 70.80 Quite High
Opioid 2 45.44 Quite Low
antagonist 4 44.88 Quite Low
Disease Link Frequency Relevance Heat
Disease 55 46.56 Quite Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Spinocerebellar Ataxia Type 2 4 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Frailty 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the lack of correlation between instability index and Msh3 expression levels across 16 tissues (Figure 6A, Additional file 2), the data argue against a major role for Msh3 expression levels in determining tissue- or cell type-specific instability.
Positive_regulation (role) of Gene_expression (expression) of Msh3
1) Confidence 0.43 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2856555 Disease Relevance 0 Pain Relevance 0
We have previously demonstrated that both endomorphin-1 (EM-1) and endomorphin-2 (EM-2) at high doses (1.75-35 nmol) given intrathecally (i.t.) or intracerebroventricularly produce antinociception by stimulation of mu-opioid receptors.
Positive_regulation (stimulation) of Gene_expression (produce) of EM-1 in EM-2 associated with antinociception and mu opioid receptor
2) Confidence 0.11 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14557378 Disease Relevance 0 Pain Relevance 1.04

General Comments

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