INT113717

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Context Info
Confidence 0.41
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 6.14
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
chondrocytes 2
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 21 99.98 Very High Very High Very High
Osteoarthritis 150 99.48 Very High Very High Very High
antagonist 55 98.12 Very High Very High Very High
metalloproteinase 46 91.88 High High
cINOD 4 91.84 High High
Infliximab 20 88.80 High High
cytokine 107 88.72 High High
Pain 26 83.04 Quite High
Inflammation 165 80.88 Quite High
Kinase C 3 79.92 Quite High
Disease Link Frequency Relevance Heat
Stress 246 100.00 Very High Very High Very High
Osteoarthritis 181 99.50 Very High Very High Very High
Adhesions 13 98.60 Very High Very High Very High
Primary Sclerosing Cholangitis 88 98.48 Very High Very High Very High
Hepatocellular Cancer 38 98.40 Very High Very High Very High
Osteoporosis 67 97.16 Very High Very High Very High
Osteolysis 7 95.28 Very High Very High Very High
Cleidocranial Dysplasia 4 93.64 High High
Apoptosis 186 92.52 High High
Multiple Myeloma 22 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, COL1 expression was significantly suppressed in physiological conditions throughout culture.
Negative_regulation (suppressed) of Gene_expression (expression) of COL1
1) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.20 Pain Relevance 0.10
In contrast, physiological tonicity significantly decreased COL1 protein expression (Figure 2f), from twofold in P0 cells to 13-fold in P1 cells.
Negative_regulation (decreased) of Gene_expression (expression) of COL1
2) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.13 Pain Relevance 0.07
As in OA HACs, hypertonicity also downregulated COL1 expression with increasing passage number in NHACs: the COL2/COL1 ratios increased during expansion (Figure 3d), from 6.8-fold in P0 cells to 355-fold in expanded P3 cells.
Negative_regulation (downregulated) of Gene_expression (expression) of COL1 associated with osteoarthritis
3) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.16 Pain Relevance 0.08
RESULTS: Disc specimens with advanced morphologic pathology showed significant labeling for fibronectin in 3 of 3 cases and for collagen I in 4 of 4 cases.
Negative_regulation (labeling) of Gene_expression (significant) of collagen I
4) Confidence 0.32 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
Aggrecan and collagen type-II gene expression, which is characteristic for hyaline cartilage, stayed elevated, while expression of the collagen type-I gene, indicating dedifferentiated chondrocytes, was slowly decreasing during cultivation.
Negative_regulation (decreasing) of Gene_expression (expression) of collagen type-I gene in chondrocytes associated with osteoarthritis
5) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921357 Disease Relevance 0.17 Pain Relevance 0
-SMA and collagen type I, the expression of these two transcripts was significantly downregulated upon addition of 10 ng/mL TNF-?
Negative_regulation (downregulated) of Gene_expression (expression) of collagen type I
6) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.07 Pain Relevance 0.40
A decrease was also observed in expression of the gene for collagen type I in cells derived from non-degenerate AF and degenerate NP; however this was significant only in cells derived from degenerate NP (P < 0.05) (Fig. 5c).
Negative_regulation (decrease) of Gene_expression (expression) of collagen type I
7) Confidence 0.21 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0 Pain Relevance 0
The observed transient decrease in PINP probably reflects reduced collagen type I synthesis caused by treatment with the glucocorticoid.


Negative_regulation (reduced) of Gene_expression (synthesis) of collagen type I
8) Confidence 0.19 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.89 Pain Relevance 0
Levels of serum alkaline phosphatase and urinary collagen type I N-telopeptide were elevated at baseline and decreased continuously during the first 3 yr of therapy.
Negative_regulation (decreased) of Gene_expression (Levels) of collagen type I N-telopeptide
9) Confidence 0.15 Published 2003 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 14557424 Disease Relevance 0.48 Pain Relevance 0.08
In the absence of vitamin D3, type I collagen alpha 1 chain expression was inhibited by 10 ?
Negative_regulation (inhibited) of Gene_expression (expression) of type I collagen alpha 1 chain
10) Confidence 0.13 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860078 Disease Relevance 0.44 Pain Relevance 0.08
Two days after 24 h of incubation, 50 microg/ml diclofenac reduced the proliferation and collagen type I expression while 9 and 16 days later no effect was found on either of the parameters.
Negative_regulation (reduced) of Gene_expression (expression) of collagen type I associated with diclofenac
11) Confidence 0.09 Published 2005 Journal Unfallchirurg Section Abstract Doc Link 16149169 Disease Relevance 0.26 Pain Relevance 0.40
Effects of PPS on proteoglycan, collagen type I and collagen type II deposition by MPCs in 5-day, 7-day and 10-day pellet cultures
Negative_regulation (deposition) of Gene_expression (proteoglycan) of collagen type I
12) Confidence 0.09 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0 Pain Relevance 0
-tocopherol to rats undergoing this protocol resulted not only in a reduction of oxidative stress, lipid peroxidation and HNE, but also in decreased synthesis of both collagen type I and TGF ?
Negative_regulation (reduction) of Gene_expression (synthesis) of collagen type I associated with stress
13) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.59 Pain Relevance 0.15
-tocopherol to rats undergoing this protocol resulted not only in a reduction of oxidative stress, lipid peroxidation and HNE, but also in decreased synthesis of both collagen type I and TGF ?
Negative_regulation (decreased) of Gene_expression (synthesis) of collagen type I associated with stress
14) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.58 Pain Relevance 0.15
HRT resulted also in a significant (P = 0.035) but less pronounced reduction in the other collagen type I degradation product, ICTP.
Negative_regulation (reduction) of Gene_expression (degradation product) of collagen type I
15) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0 Pain Relevance 0
Synthesis of collagen type I is reduced, as is expression of the cellular adhesion molecules.
Negative_regulation (reduced) of Gene_expression (Synthesis) of collagen type I associated with adhesions
16) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.39 Pain Relevance 0.04
In addition, the gene expressions in cHCC of SOCS3 and collagen-I were elevated (although not significantly) and inhibited, respectively, as it was also detected in human HCC [19].
Negative_regulation (inhibited) of Gene_expression (expressions) of collagen-I associated with hepatocellular cancer
17) Confidence 0.05 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.65 Pain Relevance 0
Immunoblot analysis of cell culture supernatants showed significantly reduced fibronectin and collagen 1 levels after WIN treatment (supernatants of PSC grown to 100% confluency before initiation of treatment; Figure 7B).
Negative_regulation (reduced) of Gene_expression (levels) of collagen 1 associated with primary sclerosing cholangitis
18) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.41 Pain Relevance 0.16
Pre-incubation with AM251 and/or AM630 (5 ┬ÁM) revealed that the suppressive effect of WIN on fibronectin and collagen 1 production was partially reversible only when using both antagonists concomitantly (Figure 7B; pooled cell culture supernatanty from three independently performed experiments).
Negative_regulation (effect) of Gene_expression (production) of collagen 1 associated with antagonist
19) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.40 Pain Relevance 0.22
The dP2 cells also exhibited higher type II collagen and lower type I collagen gene expression than the P2 cells.
Negative_regulation (exhibited) of Gene_expression (expression) of lower type I collagen gene
20) Confidence 0.04 Published 2009 Journal Tissue engineering. Part A Section Abstract Doc Link 18783319 Disease Relevance 0.27 Pain Relevance 0.08

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