INT113734

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 11.04
Pain Relevance 9.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp)
Anatomy Link Frequency
arcuate nucleus 4
spinal cord 3
internal 2
neuronal 2
DRG 2
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 91 100.00 Very High Very High Very High
antagonist 83 100.00 Very High Very High Very High
gABA 48 100.00 Very High Very High Very High
Spinal cord 17 99.84 Very High Very High Very High
Action potential 4 99.28 Very High Very High Very High
Neuropathic pain 8 99.04 Very High Very High Very High
Intracerebroventricular 10 98.92 Very High Very High Very High
dexamethasone 4 98.48 Very High Very High Very High
tetrodotoxin 16 98.32 Very High Very High Very High
Cannabinoid 15 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 356 100.00 Very High Very High Very High
Hypertrophy 6 99.56 Very High Very High Very High
Neuropathic Pain 29 99.54 Very High Very High Very High
Hyperphagia 17 98.96 Very High Very High Very High
Metabolic Syndrome 6 98.32 Very High Very High Very High
Appetite Loss 179 97.40 Very High Very High Very High
Targeted Disruption 84 96.72 Very High Very High Very High
Weight Gain 47 96.40 Very High Very High Very High
Hyperalgesia 3 96.04 Very High Very High Very High
Pain 12 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MC4 and POMC transcript were upregulated in the spinal cord of neuropathic rats, whereas MC3 and AgRP expression were unaffected.
Gene_expression (expression) of AgRP in spinal cord associated with neuropathic pain and spinal cord
1) Confidence 0.77 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.90 Pain Relevance 0.97
In addition the expression of AgRP in spinal cord and DRG suggests an endogenous tonic inhibitory control on MC system activity.
Gene_expression (expression) of AgRP in spinal cord associated with spinal cord
2) Confidence 0.76 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15617771 Disease Relevance 0.84 Pain Relevance 0.85
In this study, we examined the gene regulation of NPY and agouti-related peptide (AGRP), another orexigenic peptide synthesized in the NPY neurons, in the arcuate nucleus by ghrelin in hypothalamic organotypic cultures.
Gene_expression (synthesized) of AGRP in arcuate nucleus
3) Confidence 0.75 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.24
Repeated injections of AGRP have been shown to cause hyperphagia and obesity in healthy rats and mice (Small et al. 2001).
Gene_expression (injections) of AGRP associated with hyperphagia and metabolic syndrome
4) Confidence 0.62 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.10 Pain Relevance 0.16
AgRP was present in both spinal cord and DRG, and its expression, was unchanged in neuropathic animals.
Gene_expression (present) of AgRP in DRG associated with neuropathic pain and spinal cord
5) Confidence 0.59 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15617771 Disease Relevance 0.88 Pain Relevance 0.88
K(+)-evoked GABA release was sensitive to leptin, insulin and PYY(3-36), indicating that GABA was released by arcuate NPY/AgRP/GABA neurones.
Gene_expression (neurones) of AgRP associated with gaba
6) Confidence 0.57 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20236227 Disease Relevance 0.17 Pain Relevance 1.24
nmol AGRP (Phoenix Pharmaceuticals, Burlingame, CA, USA) dissolved in 5??
Gene_expression (dissolved) of AGRP
7) Confidence 0.54 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.05 Pain Relevance 0
These results support the conclusion that the observed increases in weight, LBM, and fat mass in Band-AGRP rats were not only due to AGRP increasing food intake, but also due to AGRP decreasing the increased metabolic rate that results from the banding procedure.
Gene_expression (rats) of AGRP in Band
8) Confidence 0.54 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.43 Pain Relevance 0
Incubation of the hypothalamic explants with ghrelin significantly increased NPY and AGRP mRNA expression in the presence, but not absence, of dexamethasone.
Gene_expression (expression) of AGRP mRNA associated with dexamethasone
9) Confidence 0.54 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.28
These data suggest that ghrelin stimulates NPY and AGRP gene expression independently of action potentials only in the presence of glucocorticoids.
Gene_expression (expression) of AGRP gene associated with action potential
10) Confidence 0.54 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.28
Glucocorticoids were also necessary for ghrelin action in vivo because an intracerebroventricular injection of ghrelin significantly increased NPY and AGRP mRNA expression in the arcuate nucleus only in sham-operated, but not in adrenalectomized rats.
Gene_expression (expression) of AGRP mRNA in arcuate nucleus associated with intracerebroventricular
11) Confidence 0.54 Published 2006 Journal Endocrinology Section Abstract Doc Link 16887908 Disease Relevance 0 Pain Relevance 0.30
Arcuate expression of Agrp, Pomc and Npy was also quantified by real time PCR in these same samples, but the RNA had to be amplified before being used as template.
Gene_expression (expression) of Agrp
12) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.14 Pain Relevance 0
This observation suggests that sbMc1r is constitutively activated and inversely regulated by AGRP, which is expressed in the skin of different fish species.
Gene_expression (expressed) of AGRP in skin
13) Confidence 0.51 Published 2010 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 19539622 Disease Relevance 0 Pain Relevance 0.15
Within the hypothalamic arcuate nucleus, two neuronal subpopulations play particularly important roles in energy balance; neurones expressing neuropeptide Y (NPY), agouti-related peptide (AgRP) and GABA are orexigenic, whereas neurones expressing pro-opiomelanocortin and CART are anorexigenic.
Gene_expression (expressing) of agouti-related peptide in neuronal associated with gaba and neuropeptide
14) Confidence 0.51 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20236227 Disease Relevance 0.15 Pain Relevance 0.46
Within the hypothalamic arcuate nucleus, two neuronal subpopulations play particularly important roles in energy balance; neurones expressing neuropeptide Y (NPY), agouti-related peptide (AgRP) and GABA are orexigenic, whereas neurones expressing pro-opiomelanocortin and CART are anorexigenic.
Gene_expression (expressing) of AgRP in neuronal associated with gaba and neuropeptide
15) Confidence 0.51 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20236227 Disease Relevance 0.15 Pain Relevance 0.46
Also, the fasting induced decrease in POMC expression and increase in AgRP expression were sensitive to Sirt1 enzymatic activity (Figure 3A, B).
Gene_expression (expression) of AgRP
16) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.24 Pain Relevance 0
Total RNA (1 µg) isolated (Trizol Reagent, Invitrogen) from fresh arcuate nucleus tissue was converted to cDNA and used to screen expression levels of Sirt1, POMC, AgRP, and tubulin (internal control).
Gene_expression (expression) of AgRP in internal
17) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.07 Pain Relevance 0
Since hypothalamic Sirt1 regulates food intake through melanocortin receptors (Figure 1C), we investigated the effect of inhibition of hypothalamic Sirt1 in POMC and AgRP expression.
Gene_expression (expression) of AgRP
18) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.28 Pain Relevance 0
Second, Sirt1 showed to regulate the expression of AgRP and POMC.
Gene_expression (expression) of AgRP
19) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.52 Pain Relevance 0.04
In contrast, knocking down Arc Fto expression by 40% increases food intake by 16%. mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Gene_expression (expressed) of Agrp in ARC associated with aids-related complex
20) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.65 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox