INT113737

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Context Info
Confidence 0.71
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 7.05
Pain Relevance 3.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Agrp)
Anatomy Link Frequency
spinal cord 2
DRG 2
hypothalamus 1
ARC 1
gut 1
Agrp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 20 99.64 Very High Very High Very High
agonist 10 97.86 Very High Very High Very High
fluoxetine 5 97.78 Very High Very High Very High
Pain 4 88.96 High High
Lasting pain 4 88.72 High High
antagonist 16 88.60 High High
Eae 4 86.64 High High
Analgesic 4 83.64 Quite High
Brush evoked pain 8 78.80 Quite High
sSRI 1 78.44 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 113 99.36 Very High Very High Very High
Appetite Loss 54 95.00 High High
Neuropathic Pain 20 94.76 High High
Myocardial Infarction 104 93.96 High High
Cancer 6 92.96 High High
Pain 8 88.96 High High
Acute Renal Failure 1 87.44 High High
Injury 4 84.96 Quite High
Hyperalgesia 12 84.84 Quite High
Sepsis 1 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Transcription (detected) of agouti-related protein in spinal cord associated with spinal cord
1) Confidence 0.71 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.90 Pain Relevance 0.84
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Transcription (detected) of AgRP in spinal cord associated with spinal cord
2) Confidence 0.71 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.89 Pain Relevance 0.84
Ghrelin, a gut-derived peptide agonist for the GH secretagogue receptor that also potently inhibits central melanocortin signaling by increasing Agrp mRNA expression (Kamegai et al. 2000) and hyperpolarizing POMC neurons (Cowley et al. 2003), has been shown to attenuate the development of cachexia in rat models of CHF (Nagaya et al. 2001).
Transcription (expression) of Agrp in gut associated with appetite loss, agonist and myocardial infarction
3) Confidence 0.49 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.35 Pain Relevance 0.18
Fluoxetine administration increased POMC expression and reduced MC4-R expression in the hypothalamus, without changes in AgRP mRNA levels.
Transcription (levels) of AgRP in hypothalamus associated with fluoxetine
4) Confidence 0.45 Published 2008 Journal Neuropeptides Section Abstract Doc Link 18359080 Disease Relevance 0.40 Pain Relevance 0.44
ICV infusion of EX527 to fasted rats resulted in an increased POMC (Figure 3A) and a decreased AgRP mRNA levels (Figure 3B).
Transcription (levels) of AgRP
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2790615 Disease Relevance 0.29 Pain Relevance 0
mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Transcription (levels) of Agrp associated with aids-related complex
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.78 Pain Relevance 0
In contrast, knocking down Arc Fto expression by 40% increases food intake by 16%. mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Transcription (levels) of Agrp in ARC associated with aids-related complex
7) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808248 Disease Relevance 0.65 Pain Relevance 0
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Transcription (detected) of AgRP in DRG associated with spinal cord
8) Confidence 0.24 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.89 Pain Relevance 0.84
MC4 receptor, proopiomelanocortin (POMC) and agouti-related protein (AgRP) transcripts were detected in both spinal cord and DRG, whereas MC3 receptor was detected only in the spinal cord.
Transcription (detected) of agouti-related protein in DRG associated with spinal cord
9) Confidence 0.24 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559360 Disease Relevance 0.90 Pain Relevance 0.84

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