INT11374

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Context Info
Confidence 0.67
First Reported 1992
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 3.27
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Es2)
Anatomy Link Frequency
temporalis 1
Es2 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 18 99.04 Very High Very High Very High
tolerance 2 95.28 Very High Very High Very High
Pain 23 94.88 High High
Migraine 4 93.48 High High
depression 4 91.04 High High
Central nervous system 1 87.20 High High
agonist 2 75.96 Quite High
hyperexcitability 1 72.40 Quite High
Potency 1 64.24 Quite High
Antinociceptive 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Headache 17 99.04 Very High Very High Very High
Migraine Without Aura 3 98.96 Very High Very High Very High
Infection 1 97.48 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 97.08 Very High Very High Very High
Meningitis 1 95.84 Very High Very High Very High
Pain 11 94.88 High High
Lumbar Puncture Related Headaches 1 94.72 High High
Hypoalagesia 1 93.68 High High
Depression 4 91.04 High High
Shock 1 87.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the depth of ES2 suppression in the left MM was significantly higher than that in the right MM at 50% MVC (70.0+/-7.4%, P<0.05).
Gene_expression (suppression) of ES2
1) Confidence 0.67 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 15927142 Disease Relevance 0 Pain Relevance 0
The depth of ES2 suppression in the left MM was 69.7+/-5.7% at 30% MVC, and this increased significantly to 76.6+/-5.5% at 50% MVC (P<0.05).
Gene_expression (suppression) of ES2
2) Confidence 0.67 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 15927142 Disease Relevance 0 Pain Relevance 0
METHODS: ES2 was assessed in 46 healthy volunteers running through four experimentally induced psychophysiological conditions: stress, relaxation, depressed mood, and heterotopic pressure pain.
Gene_expression (assessed) of ES2
3) Confidence 0.58 Published 2009 Journal J Psychosom Res Section Body Doc Link 19446711 Disease Relevance 0 Pain Relevance 0
RESULTS: ES2 duration was found to be prolonged and ES2 latency to be shortened under the impact of relaxation and depressed mood.
Gene_expression (prolonged) of ES2
4) Confidence 0.58 Published 2009 Journal J Psychosom Res Section Body Doc Link 19446711 Disease Relevance 0 Pain Relevance 0
RESULTS: ES2 duration was found to be prolonged and ES2 latency to be shortened under the impact of relaxation and depressed mood.
Gene_expression (duration) of ES2
5) Confidence 0.58 Published 2009 Journal J Psychosom Res Section Body Doc Link 19446711 Disease Relevance 0 Pain Relevance 0
ES2 was absent in about 50% of tension-type headache patients, but only in one normal subject.
Neg (absent) Gene_expression (absent) of ES2 associated with headache
6) Confidence 0.52 Published 1992 Journal Headache Section Abstract Doc Link 1555931 Disease Relevance 1.20 Pain Relevance 0.91
After an index finger stimulus of 20 mA, temporalis ES2 was abolished in 83% of CTH, 67% of ETH, 25% of MO patients and 8% of controls, whereas unconditioned ES2 was present in all patients.
Gene_expression (present) of ES2 in temporalis associated with migraine without aura
7) Confidence 0.52 Published 1994 Journal Pain Section Abstract Doc Link 7708406 Disease Relevance 0.56 Pain Relevance 0.50
ES2 produced by four times the sensory threshold was lengthened after tizanidine administration.
Gene_expression (produced) of ES2
8) Confidence 0.46 Published 1994 Journal Headache Section Abstract Doc Link 7960728 Disease Relevance 0.31 Pain Relevance 0.43
Significant prolongation of ES2 duration was only found in acutely depressed patients off medication.
Gene_expression (duration) of ES2
9) Confidence 0.40 Published 2003 Journal J Psychiatr Res Section Abstract Doc Link 12765857 Disease Relevance 1.19 Pain Relevance 1.05

General Comments

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