INT11375

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 1985
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 6.52
Pain Relevance 5.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Es2)
Anatomy Link Frequency
temporalis 3
neurons 1
muscle 1
inhibitory interneurons 1
Es2 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 55 99.92 Very High Very High Very High
cva 3 99.36 Very High Very High Very High
depression 1 98.64 Very High Very High Very High
Migraine 13 98.48 Very High Very High Very High
Cluster headache 1 97.76 Very High Very High Very High
drug abuse 1 92.64 High High
Pain 4 90.16 High High
Catecholamine 1 80.08 Quite High
cerebral cortex 1 78.56 Quite High
medulla 3 75.44 Quite High
Disease Link Frequency Relevance Heat
Headache 50 99.92 Very High Very High Very High
Tension-type Headache 3 99.84 Very High Very High Very High
Hemorrhage 3 99.36 Very High Very High Very High
Depression 1 98.64 Very High Very High Very High
Migraine Without Aura 6 98.60 Very High Very High Very High
Cluster Headache 1 97.76 Very High Very High Very High
Shock 4 95.24 Very High Very High Very High
Migraine Disorders 2 92.96 High High
Drug Dependence 1 92.64 High High
Nociception 1 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of ES2 suggests that there is deficient activation or excessive inhibition of pontobulbar inhibitory interneurons which receive a strong input from limbic structures.
Negative_regulation (Reduction) of ES2 in inhibitory interneurons
1) Confidence 0.50 Published 1987 Journal Neurology Section Abstract Doc Link 3683873 Disease Relevance 0.79 Pain Relevance 0.69
The depth of ES2 suppression in the left MM was 69.7+/-5.7% at 30% MVC, and this increased significantly to 76.6+/-5.5% at 50% MVC (P<0.05).
Negative_regulation (suppression) of ES2
2) Confidence 0.43 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 15927142 Disease Relevance 0 Pain Relevance 0
In addition, the depth of ES2 suppression in the left MM was significantly higher than that in the right MM at 50% MVC (70.0+/-7.4%, P<0.05).
Negative_regulation (suppression) of ES2
3) Confidence 0.43 Published 2005 Journal Arch. Oral Biol. Section Abstract Doc Link 15927142 Disease Relevance 0 Pain Relevance 0
Temporalis ES2 may be decreased in untreated patients with major depression.
Negative_regulation (decreased) of ES2 in Temporalis associated with depression
4) Confidence 0.37 Published 1993 Journal Headache Section Abstract Doc Link 8436496 Disease Relevance 0.91 Pain Relevance 1.04
After an index finger stimulus of 20 mA, temporalis ES2 was abolished in 83% of CTH, 67% of ETH, 25% of MO patients and 8% of controls, whereas unconditioned ES2 was present in all patients.
Negative_regulation (abolished) of ES2 in temporalis associated with migraine without aura
5) Confidence 0.37 Published 1994 Journal Pain Section Abstract Doc Link 7708406 Disease Relevance 0.58 Pain Relevance 0.50
From stimulation intensities of 20 mA onward, peripheral-induced inhibition of temporalis ES2 was significantly more pronounced in both subtypes of tension-type headache compared to migraineurs or controls.
Negative_regulation (inhibition) of ES2 in temporalis associated with headache
6) Confidence 0.37 Published 1994 Journal Pain Section Abstract Doc Link 7708406 Disease Relevance 0.59 Pain Relevance 0.47
Exteroceptive suppression (ES) of temporalis muscle activity, particularly the multisynaptic ES2, has been reported to be significantly reduced in tension type headache, but not in migraine.
Negative_regulation (reduced) of ES2 in muscle associated with tension-type headache, migraine and headache
7) Confidence 0.37 Published 1992 Journal Headache Section Abstract Doc Link 1555931 Disease Relevance 1.02 Pain Relevance 0.71
This difference was due to a marked menstrual reduction of ES2 in the headache subgroup.
Negative_regulation (reduction) of ES2 associated with headache
8) Confidence 0.37 Published 1991 Journal Cephalalgia Section Abstract Doc Link 1860134 Disease Relevance 0.27 Pain Relevance 0.31
At a stimulation rate of 2 Hz, ES2 was abolished in 40% of tension headache sufferers, but in none of the migraineurs.
Negative_regulation (abolished) of ES2 associated with headache
9) Confidence 0.37 Published 1987 Journal Neurology Section Abstract Doc Link 3683873 Disease Relevance 0.83 Pain Relevance 0.70
The reduction of ES 2 in chronic tension headache sufferers might suggest a deficient activation or excessive inhibition of the motoric trigeminus nucleus by pontobulbar inhibitory neurons which receive a strong input from limbic and nociceptive structures.
Negative_regulation (reduction) of ES 2 in neurons associated with nociception and headache
10) Confidence 0.35 Published 1991 Journal Nervenarzt Section Abstract Doc Link 2034307 Disease Relevance 1.13 Pain Relevance 0.96
Thus, one of the factors determining survival after hemorrhage may be related to the relative dominance of alpha 1 and Es alpha 2 receptors during the initial compensatory response.
Negative_regulation (dominance) of Es alpha 2 associated with cva
11) Confidence 0.00 Published 1985 Journal Fed. Proc. Section Abstract Doc Link 3967773 Disease Relevance 0.40 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox