INT113769

Context Info Confidence 0.09 First Reported 2003 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 0.29 Pain Relevance 2.21

plasma membrane (Grid1)

Grid1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat central sensitization 2 99.84 Pain 16 99.74 Kinase C 90 98.48 Inflammation 13 97.88 nMDA receptor 5 95.52 Glutamate 10 92.60 Dorsal horn neuron 5 86.48 intrathecal 26 85.56 qutenza 12 79.20 Spinal cord 28 76.60

Disease Link Frequency Relevance Heat Pain 7 99.74 INFLAMMATION 7 97.88 Hyperalgesia 28 50.00 Nociception 6 39.36 Urological Neuroanatomy 2 13.04 Injury 7 5.00 Neuropathic Pain 5 5.00 Myalgia 4 5.00 Targeted Disruption 2 5.00 Pancreatitis 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our results suggest that increased phosphorylation of the GluR1 subunit of AMPA receptors contributes to central sensitization following acute peripheral inflammation, and the effect may occur at different phosphorylation sites through the activation of the PKA or PKC protein kinase cascades.

Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluR1 subunit associated with kinase c, inflammation and central sensitization

1) Confidence 0.09 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559367 Disease Relevance 0.10 Pain Relevance 0.54

Our results suggest that increased phosphorylation of the GluR1 subunit of AMPA receptors contributes to central sensitization following acute peripheral inflammation, and the effect may occur at different phosphorylation sites through the activation of the PKA or PKC protein kinase cascades.

Positive_regulation (contributes) of Phosphorylation (phosphorylation) of GluR1 subunit associated with kinase c, inflammation and central sensitization

2) Confidence 0.09 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559367 Disease Relevance 0.10 Pain Relevance 0.54

Indeed, in animal models of pain there is an increase in phosphorylation of the NR1 subunit and GlurR1 subunit that likely depends on activation of PKC [32-36].

Positive_regulation (increase) of Phosphorylation (phosphorylation) of GlurR1 subunit associated with pain and kinase c

3) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.10 Pain Relevance 1.14

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