INT113769

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.29
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grid1)
Grid1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
central sensitization 2 99.84 Very High Very High Very High
Pain 16 99.74 Very High Very High Very High
Kinase C 90 98.48 Very High Very High Very High
Inflammation 13 97.88 Very High Very High Very High
nMDA receptor 5 95.52 Very High Very High Very High
Glutamate 10 92.60 High High
Dorsal horn neuron 5 86.48 High High
intrathecal 26 85.56 High High
qutenza 12 79.20 Quite High
Spinal cord 28 76.60 Quite High
Disease Link Frequency Relevance Heat
Pain 7 99.74 Very High Very High Very High
INFLAMMATION 7 97.88 Very High Very High Very High
Hyperalgesia 28 50.00 Quite Low
Nociception 6 39.36 Quite Low
Urological Neuroanatomy 2 13.04 Low Low
Injury 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 5 5.00 Very Low Very Low Very Low
Myalgia 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Pancreatitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that increased phosphorylation of the GluR1 subunit of AMPA receptors contributes to central sensitization following acute peripheral inflammation, and the effect may occur at different phosphorylation sites through the activation of the PKA or PKC protein kinase cascades.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GluR1 subunit associated with kinase c, inflammation and central sensitization
1) Confidence 0.09 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559367 Disease Relevance 0.10 Pain Relevance 0.54
Our results suggest that increased phosphorylation of the GluR1 subunit of AMPA receptors contributes to central sensitization following acute peripheral inflammation, and the effect may occur at different phosphorylation sites through the activation of the PKA or PKC protein kinase cascades.
Positive_regulation (contributes) of Phosphorylation (phosphorylation) of GluR1 subunit associated with kinase c, inflammation and central sensitization
2) Confidence 0.09 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559367 Disease Relevance 0.10 Pain Relevance 0.54
Indeed, in animal models of pain there is an increase in phosphorylation of the NR1 subunit and GlurR1 subunit that likely depends on activation of PKC [32-36].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GlurR1 subunit associated with pain and kinase c
3) Confidence 0.01 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.10 Pain Relevance 1.14

General Comments

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