INT11377

Context Info Confidence 0.70 First Reported 1980 Last Reported 2011 Negated 9 Speculated 18 Reported most in Abstract Documents 331 Total Number 355 Disease Relevance 206.50 Pain Relevance 238.00

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf) extracellular region (Ngf) molecular_function (Ngf)

Anatomy Link Frequency nerve 79 neurons 20 DRG 16 bladder 14 skin 9 Ngf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nerve growth factor 6001 100.00 Calcitonin gene-related peptide 956 100.00 Pain 855 100.00 Inflammation 773 100.00 Spinal cord 693 100.00 qutenza 591 100.00 Hyperalgesia 523 100.00 dorsal root ganglion 500 100.00 nociceptor 257 100.00 cytokine 89 100.00

Disease Link Frequency Relevance Heat Ganglion Cysts 1106 100.00 Injury 1079 100.00 Pain 828 100.00 Hyperalgesia 741 100.00 INFLAMMATION 737 100.00 Cancer 58 100.00 Cystitis 50 100.00 Necrosis 19 100.00 Nervous System Injury 327 99.96 Headache 91 99.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, increased NGF was present in skin after plantar incision.

Positive_regulation (increased) of NGF in skin associated with nerve growth factor

1) Confidence 0.70 Published 2005 Journal Pain Section Abstract Doc Link 16061324 Disease Relevance 0.51 Pain Relevance 1.30

NGF content was increased in the L4 dorsal root ganglion on the ipsilateral, but not the contralateral, side, in CCI rats treated with ropivacaine.

Positive_regulation (increased) of NGF in dorsal root ganglion

2) Confidence 0.70 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18165597 Disease Relevance 0.13 Pain Relevance 0

Regeneration of the sciatic nerve alleviated the accumulation of NGF in the injured side hindpaw skin on day 32.

Positive_regulation (accumulation) of NGF in skin associated with nerve growth factor and sciatic nerve

3) Confidence 0.70 Published 2004 Journal J Nippon Med Sch Section Abstract Doc Link 15673961 Disease Relevance 0.43 Pain Relevance 0.82

Moreover, rats injected daily with anti-NGF serum after burn injury did not develop hyperalgesia, suggesting that increased NGF in the tissue of the healing skin is a key factor causing systemic hyperalgesia during the recovery stage.

Positive_regulation (increased) of NGF in skin associated with hyperalgesia, nerve growth factor, burns and injury

4) Confidence 0.70 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12133564 Disease Relevance 1.19 Pain Relevance 0.83

Nerve growth factor (NGF) in the skin of the hindpaw on the injured side was accumulated after incomplete ligation and incomplete crush of the left L4 and L5 spinal nerves, but not tight ligation of the left L5 spinal nerve, on day 15 after the operation, possibly due to impairment of transport via unmyelinated primary afferents.

Spec (possibly) Positive_regulation (accumulated) of NGF in Nerve associated with nerve growth factor and unmyelinated

5) Confidence 0.70 Published 2004 Journal J Nippon Med Sch Section Abstract Doc Link 15673961 Disease Relevance 0.50 Pain Relevance 0.87

Nerve growth factor (NGF) in the skin of the hindpaw on the injured side was accumulated after incomplete ligation and incomplete crush of the left L4 and L5 spinal nerves, but not tight ligation of the left L5 spinal nerve, on day 15 after the operation, possibly due to impairment of transport via unmyelinated primary afferents.

Spec (possibly) Positive_regulation (accumulated) of Nerve growth factor in Nerve associated with nerve growth factor and unmyelinated

6) Confidence 0.70 Published 2004 Journal J Nippon Med Sch Section Abstract Doc Link 15673961 Disease Relevance 0.51 Pain Relevance 0.88

Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI.

Positive_regulation (increased) of NGF in nerve associated with hyperalgesia, nerve growth factor and eae

7) Confidence 0.70 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189901 Disease Relevance 1.04 Pain Relevance 1.17

Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI.

Positive_regulation (increase) of NGF in ganglia associated with hyperalgesia, nerve growth factor and eae

8) Confidence 0.70 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189901 Disease Relevance 1.06 Pain Relevance 1.17

Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI.

Positive_regulation (increase) of NGF in ganglia associated with hyperalgesia, nerve growth factor and eae

9) Confidence 0.70 Published 1997 Journal Neuroreport Section Abstract Doc Link 9189901 Disease Relevance 1.08 Pain Relevance 1.21

Evidence suggests that nerve growth factor (NGF) is an important mediator in inflammatory pain states: NGF levels increase in inflamed tissue, and neutralization of endogenous NGF prevents the hyperalgesia which normally develops during inflammation of the skin.

Positive_regulation (increase) of NGF in nerve associated with hyperalgesia, inflammation, nerve growth factor and ipn

10) Confidence 0.70 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215923 Disease Relevance 0.45 Pain Relevance 0.96

We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia.

Spec (whether) Positive_regulation (elevation) of NGF in nerve associated with hyperalgesia, inflammation and nerve growth factor

11) Confidence 0.70 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141043 Disease Relevance 0.87 Pain Relevance 0.67

We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia.

Spec (whether) Positive_regulation (elevation) of nerve growth factor in nerve associated with hyperalgesia, inflammation and nerve growth factor

12) Confidence 0.70 Published 1997 Journal Neuroreport Section Abstract Doc Link 9141043 Disease Relevance 0.87 Pain Relevance 0.67

CONCLUSION: NGF mRNA is increased and a large-molecular-weight form of NGF protein is expressed in the region adjacent to the incision.

Positive_regulation (increased) of NGF mRNA

13) Confidence 0.70 Published 2007 Journal Anesthesiology Section Body Doc Link 17585224 Disease Relevance 0 Pain Relevance 0

Nerve growth factor (NGF) content of the spinal cord is increased after cord injury.

Positive_regulation (increased) of Nerve growth factor in Nerve associated with nerve growth factor, injury and spinal cord

14) Confidence 0.70 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15191808 Disease Relevance 0.69 Pain Relevance 0.58

Nerve growth factor (NGF) content of the spinal cord is increased after cord injury.

Positive_regulation (increased) of NGF in Nerve associated with nerve growth factor, injury and spinal cord

15) Confidence 0.70 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15191808 Disease Relevance 0.69 Pain Relevance 0.58

BACKGROUND & AIMS: In somatic pain models, increases in nerve growth factor (NGF) are linked to the development of pain and hyperalgesia.

Positive_regulation (increases) of nerve growth factor in nerve associated with pain, hyperalgesia, nerve growth factor and somatic pain

16) Confidence 0.70 Published 2000 Journal Gastroenterology Section Abstract Doc Link 11054396 Disease Relevance 0.37 Pain Relevance 0.48

In contrast, mast cell degranulation produced by several days of treatment with the cationic secretagogue compound 48/80, while also increasing basal NGF levels, prevented a further increase in NGF levels and attenuated hypersensitivity during inflammation.

Positive_regulation (increase) of NGF in mast cell associated with inflammation, nerve growth factor and hypersensitivity

17) Confidence 0.70 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8786447 Disease Relevance 1.14 Pain Relevance 1.08

In contrast, mast cell degranulation produced by several days of treatment with the cationic secretagogue compound 48/80, while also increasing basal NGF levels, prevented a further increase in NGF levels and attenuated hypersensitivity during inflammation.

Positive_regulation (increasing) of NGF in mast cell associated with inflammation, nerve growth factor and hypersensitivity

18) Confidence 0.70 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8786447 Disease Relevance 1.14 Pain Relevance 1.08

Although the treatment with a control virus did not change NGF levels compared with those of naive animals, the vector encoding for NGF increased NGF protein levels in the bladder 4-fold.

Positive_regulation (increased) of NGF in bladder associated with nerve growth factor

19) Confidence 0.70 Published 2004 Journal J Pain Section Abstract Doc Link 15106127 Disease Relevance 0.45 Pain Relevance 0.80

Eight weeks of Neotrofin treatment prevented depletion of NGF protein in plantar foot skin and sciatic nerve of diabetic rats and increased NGF protein in associated skeletal muscles.

Positive_regulation (increased) of NGF protein in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve

20) Confidence 0.70 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16507305 Disease Relevance 0.44 Pain Relevance 0.46

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