INT11377
From wiki-pain
|
|
|
|
|
Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In conclusion, increased NGF was present in skin after plantar incision. | |||||||||||||||
| |||||||||||||||
|
NGF content was increased in the L4 dorsal root ganglion on the ipsilateral, but not the contralateral, side, in CCI rats treated with ropivacaine. | |||||||||||||||
| |||||||||||||||
|
Regeneration of the sciatic nerve alleviated the accumulation of NGF in the injured side hindpaw skin on day 32. | |||||||||||||||
| |||||||||||||||
|
Moreover, rats injected daily with anti-NGF serum after burn injury did not develop hyperalgesia, suggesting that increased NGF in the tissue of the healing skin is a key factor causing systemic hyperalgesia during the recovery stage. | |||||||||||||||
| |||||||||||||||
|
Nerve growth factor (NGF) in the skin of the hindpaw on the injured side was accumulated after incomplete ligation and incomplete crush of the left L4 and L5 spinal nerves, but not tight ligation of the left L5 spinal nerve, on day 15 after the operation, possibly due to impairment of transport via unmyelinated primary afferents. | |||||||||||||||
| |||||||||||||||
|
Nerve growth factor (NGF) in the skin of the hindpaw on the injured side was accumulated after incomplete ligation and incomplete crush of the left L4 and L5 spinal nerves, but not tight ligation of the left L5 spinal nerve, on day 15 after the operation, possibly due to impairment of transport via unmyelinated primary afferents. | |||||||||||||||
| |||||||||||||||
|
Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI. | |||||||||||||||
| |||||||||||||||
|
Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI. | |||||||||||||||
| |||||||||||||||
|
Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI. | |||||||||||||||
| |||||||||||||||
|
Evidence suggests that nerve growth factor (NGF) is an important mediator in inflammatory pain states: NGF levels increase in inflamed tissue, and neutralization of endogenous NGF prevents the hyperalgesia which normally develops during inflammation of the skin. | |||||||||||||||
| |||||||||||||||
|
We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia. | |||||||||||||||
| |||||||||||||||
|
We have now examined whether the elevation in nerve growth factor (NGF) induced by the inflammation contributes to this progressive hyperalgesia. | |||||||||||||||
| |||||||||||||||
|
CONCLUSION: NGF mRNA is increased and a large-molecular-weight form of NGF protein is expressed in the region adjacent to the incision. | |||||||||||||||
| |||||||||||||||
|
Nerve growth factor (NGF) content of the spinal cord is increased after cord injury. | |||||||||||||||
| |||||||||||||||
|
Nerve growth factor (NGF) content of the spinal cord is increased after cord injury. | |||||||||||||||
| |||||||||||||||
|
BACKGROUND & AIMS: In somatic pain models, increases in nerve growth factor (NGF) are linked to the development of pain and hyperalgesia. | |||||||||||||||
| |||||||||||||||
|
In contrast, mast cell degranulation produced by several days of treatment with the cationic secretagogue compound 48/80, while also increasing basal NGF levels, prevented a further increase in NGF levels and attenuated hypersensitivity during inflammation. | |||||||||||||||
| |||||||||||||||
|
In contrast, mast cell degranulation produced by several days of treatment with the cationic secretagogue compound 48/80, while also increasing basal NGF levels, prevented a further increase in NGF levels and attenuated hypersensitivity during inflammation. | |||||||||||||||
| |||||||||||||||
|
Although the treatment with a control virus did not change NGF levels compared with those of naive animals, the vector encoding for NGF increased NGF protein levels in the bladder 4-fold. | |||||||||||||||
| |||||||||||||||
|
Eight weeks of Neotrofin treatment prevented depletion of NGF protein in plantar foot skin and sciatic nerve of diabetic rats and increased NGF protein in associated skeletal muscles. | |||||||||||||||
| |||||||||||||||
|
General Comments
This test has worked.