INT11378

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Context Info
Confidence 0.59
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 10.28
Pain Relevance 7.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
plasma 4
chondrocyte 2
monocytes 2
cartilage 2
gastric juice 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 99 100.00 Very High Very High Very High
dexamethasone 59 99.98 Very High Very High Very High
Opioid 2 99.82 Very High Very High Very High
antagonist 14 99.70 Very High Very High Very High
Inflammation 154 99.48 Very High Very High Very High
anesthesia 4 99.44 Very High Very High Very High
corticosteroid 2 99.44 Very High Very High Very High
Pain 33 99.40 Very High Very High Very High
Pain management 5 98.22 Very High Very High Very High
Adalimumab 1 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 24 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
INFLAMMATION 182 99.48 Very High Very High Very High
Pain 34 99.40 Very High Very High Very High
Cv General 3 Under Development 4 98.96 Very High Very High Very High
Aging 3 98.88 Very High Very High Very High
Experimental Arthritis 2 96.00 Very High Very High Very High
Post Operative Pain 6 95.98 Very High Very High Very High
Arthralgia 3 95.72 Very High Very High Very High
Rheumatoid Arthritis 151 95.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After this culture period, monocytes had a marked decrease in the ability to accumulate IL1-beta mRNA, suggesting that cell aging may be one mechanism involved in producing these transcriptional differences.
Negative_regulation (decrease) of Positive_regulation (accumulate) of IL1-beta in monocytes associated with aging
1) Confidence 0.59 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.66 Pain Relevance 0.13
Another series of human studies describes an interaction between the effectiveness of postoperative pain relief and surgery-associated immune alterations: In three separate studies, the more effective pain management technique was associated with diminished surgery-induced immune alterations, especially diminished elevation of IL-1.
Negative_regulation (diminished) of Positive_regulation (elevation) of IL-1 associated with pain management and perioperative pain
2) Confidence 0.58 Published 2006 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040817 Disease Relevance 0.74 Pain Relevance 0.85
Eradication of H. pylori decreases IL-1beta induction, resulting in an increase in gastric juice acidity and normalization of serum gastrin levels.
Negative_regulation (decreases) of Positive_regulation (induction) of IL-1beta in gastric juice
3) Confidence 0.57 Published 1999 Journal J. Gastroenterol. Section Abstract Doc Link 10616759 Disease Relevance 0.46 Pain Relevance 0.07
Both drugs at micromolar concentrations (10-30 microM) showed an apparent inhibition of IL-1 alpha-induced increases in radioactivity associated with free AA.
Negative_regulation (inhibition) of Positive_regulation (increases) of IL-1
4) Confidence 0.43 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2512925 Disease Relevance 0.08 Pain Relevance 0.23
IL-1 induced IL-6 release was inhibited by ibuprofen and the salicylates where as IL-1 induced APMA-activated collagenase was only inhibited by the salicylates.
Negative_regulation (inhibited) of Positive_regulation (induced) of IL-1
5) Confidence 0.43 Published 1995 Journal J. Rheumatol. Section Body Doc Link 7674242 Disease Relevance 0 Pain Relevance 0
Reduced elevation of postoperative IL-1 and effective pain relief may both contribute to an attenuated illness response and a better surgery outcome.
Negative_regulation (Reduced) of Positive_regulation (elevation) of IL-1 associated with pain
6) Confidence 0.42 Published 2006 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040817 Disease Relevance 0.73 Pain Relevance 0.83
Tenidap, a new anti-inflammatory and antiarthritic agent, inhibited the release and maturation of IL-1 beta induced in vitro by ATP treatment of murine peritoneal macrophages.
Negative_regulation (inhibited) of Positive_regulation (induced) of IL-1 in peritoneal macrophages associated with inflammation
7) Confidence 0.42 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.27 Pain Relevance 0.23
ACECLO, DICLO, INDO, NIM significantly inhibited basal and IL-1beta stimulated IL-6 production; CELE and IBUP only inhibited IL-1beta stimulated IL-6 production; and ROFE and PIROX had no significant effects.
Negative_regulation (inhibited) of Positive_regulation (stimulated) of IL-1beta
8) Confidence 0.41 Published 2002 Journal J. Rheumatol. Section Body Doc Link 11950021 Disease Relevance 0 Pain Relevance 0
COX inhibitors indomethacin and BF389, as well as the glucocorticoid dexamethasone (DEX) and pyrrolidinedithiocarbamate, which is an inhibitor of nuclear factor kappaB as well as a potent antioxidant, inhibited IL-1beta induced PGE2 secretion.
Negative_regulation (inhibited) of Positive_regulation (induced) of IL-1beta associated with dexamethasone
9) Confidence 0.41 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.80 Pain Relevance 0.49
In addition, DEX reduced the IL-1beta induced COX-2 immunoreactivity in the same concentration as wherein it inhibited PGE2 secretion.
Negative_regulation (reduced) of Positive_regulation (induced) of IL-1beta associated with dexamethasone
10) Confidence 0.41 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.78 Pain Relevance 0.47
Palmitoyl trifluormethyl ketone, an inhibitor of Ca(2+) independent phospholipase A2 (iPLA2) and a less potent inhibitor of cytosolic PLA2, dose-dependently reduced the IL-1beta induced PGE2 secretion.
Negative_regulation (reduced) of Positive_regulation (induced) of IL-1beta
11) Confidence 0.41 Published 2001 Journal Exp. Gerontol. Section Abstract Doc Link 11250126 Disease Relevance 0.69 Pain Relevance 0.41
METHODS: We measured plasma levels of interleukin-1 beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) in 97 patients: 67 with stable angina, 24 with unstable angina, and 15 healthy controls.
Negative_regulation (measured) of Positive_regulation (levels) of IL-1beta in plasma
12) Confidence 0.41 Published 2000 Journal J. Thromb. Thrombolysis Section Body Doc Link 10728019 Disease Relevance 0.19 Pain Relevance 0
The opioid-induced increase in IL-1 beta was blocked by naltrexone in the group tested.
Negative_regulation (blocked) of Positive_regulation (increase) of IL-1 beta associated with opioid
13) Confidence 0.41 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15979578 Disease Relevance 0.31 Pain Relevance 0.33
Interestingly, the IL1B induced increase in TRPC3 expression does not appear to be influenced by PTGS2 mediated prostaglandin synthesis, as nimesulide (a PTGS2 specific inhibitor) does not inhibit the response [26].
Negative_regulation (influenced) of Positive_regulation (increase) of IL1B
14) Confidence 0.39 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892065 Disease Relevance 0.06 Pain Relevance 0.11
Concurrently, cortisol (0.01 approximately 1 microM) decreased rather than increased proinflammatory cytokine mRNA levels, including interleukin 1 beta (IL1B), interleukin 6 (IL6), and tumor necrosis factor alpha (TNF), in a dose-dependent manner in human amnion fibroblasts.
Negative_regulation (decreased) of Positive_regulation (increased) of IL1B in fibroblasts associated with necrosis, cancer and cytokine
15) Confidence 0.33 Published 2008 Journal Biol. Reprod. Section Abstract Doc Link 17901074 Disease Relevance 0.27 Pain Relevance 0.17
One study has also shown that dexamethasone (DEX) contributed to the downregulation of MAM-induced IL1B and TNF- gene expression [93].
Negative_regulation (downregulation) of Positive_regulation (induced) of IL1B associated with dexamethasone
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.89 Pain Relevance 0.72
BOL-303242-X and TA both inhibited LPS-induced increases in cellular levels of IL-1ß and ICAM-1 in HRECs, and a statistically significant reduction of LPS-induced increases in the cellular levels of IL-1ß and ICAM-1 was observed at doses ranging from 0.1 to 10 µM (Figure 4).


Negative_regulation (inhibited) of Positive_regulation (increases) of IL-1
17) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.31 Pain Relevance 0.41
We have recently demonstrated in the Haqqi model of human cartilage explants, that extracts of sierrasil reduced cartilage degradation in response to IL-1?
Negative_regulation (reduced) of Positive_regulation (response) of IL-1 in cartilage
18) Confidence 0.13 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1276811 Disease Relevance 0.68 Pain Relevance 0.42
Protamine blocked the heparin-induced increase in tumour necrosis factor alpha and interleukin-1 beta.
Negative_regulation (blocked) of Positive_regulation (increase) of interleukin-1 beta associated with necrosis and cancer
19) Confidence 0.09 Published 1996 Journal Anaesthesia Section Abstract Doc Link 8758154 Disease Relevance 0.71 Pain Relevance 0.37
Both of these antagonists significantly attenuated the BzATP-induced IL-1?
Negative_regulation (attenuated) of Positive_regulation (induced) of IL-1 associated with antagonist
20) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.07 Pain Relevance 0.13

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