INT113784

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Smyd5) cellular_component (Smyd5) biological_process (Smyd5)
Anatomy Link Frequency
lateral 1
motoneurons 1
Smyd5 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal excitability 1 96.44 Very High Very High Very High
fifth nerve 2 94.68 High High
fluoxetine 32 82.20 Quite High
medulla 15 72.08 Quite High
5HT 7 71.68 Quite High
anesthesia 1 57.20 Quite High
Locus ceruleus 1 49.04 Quite Low
Raphe 4 46.96 Quite Low
Serotonin 6 5.00 Very Low Very Low Very Low
antidepressant 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rabies Virus Infection 1 82.16 Quite High
Acidosis 57 81.64 Quite High
Shock 1 62.24 Quite High
Sudden Infant Death Syndrome 6 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Rare Diseases 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Hypoventilation 2 5.00 Very Low Very Low Very Low
Hypoxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results lead to the hypothesis that the trigeminal afferents in the mouse neonate involve at least two pathways to activate the RRG, one that may act through the medullary lateral reticular area and one that releases the A5 inhibition received by the RRG.
Positive_regulation (activate) of RRG in lateral
1) Confidence 0.41 Published 2004 Journal J. Neurophysiol. Section Abstract Doc Link 14561692 Disease Relevance 0.14 Pain Relevance 0.14
Similarly 5-HT exerts multiple effects on the neonatal respiratory network, facilitating the RRG via 5-HT1A receptors, depolarizing and firing the phrenic motoneurons via 5-HT2A receptors and reducing the transmission of the respiratory drive to motoneurons via 5-HT1B receptors [14], [16], [24], [25], [36], [39].
Positive_regulation (facilitating) of RRG in motoneurons
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964329 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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