INT11379

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Context Info
Confidence 0.49
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 7.20
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
chondrocyte 2
cartilage 2
lymphocyte 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 46 100.00 Very High Very High Very High
Inflammatory marker 3 98.72 Very High Very High Very High
Inflammation 118 98.56 Very High Very High Very High
corticosteroid 2 98.56 Very High Very High Very High
Osteoarthritis 365 98.48 Very High Very High Very High
metalloproteinase 22 98.08 Very High Very High Very High
Arthritis 31 94.96 High High
rheumatoid arthritis 67 92.28 High High
Pain 37 90.76 High High
cINOD 8 86.52 High High
Disease Link Frequency Relevance Heat
Cancer 35 99.84 Very High Very High Very High
Necrosis 9 99.60 Very High Very High Very High
INFLAMMATION 129 98.56 Very High Very High Very High
Osteoarthritis 367 98.48 Very High Very High Very High
Experimental Arthritis 3 96.00 Very High Very High Very High
Crystal Associated Disease 1 94.12 High High
Thyroiditis 73 94.00 High High
Arthritis 39 94.00 High High
Infectious Arthritis 1 93.76 High High
Asthma 4 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A dose-dependent inhibition of IL-1beta and TPA stimulated MMP activity by gallium nitrate at increasing concentrations occurs, demonstrating that gallium nitrate can be a useful modulator of inflammation in arthritis.
Positive_regulation (stimulated) of Negative_regulation (inhibition) of IL-1beta associated with inflammation and arthritis
1) Confidence 0.49 Published 2005 Journal Med. Hypotheses Section Abstract Doc Link 16122880 Disease Relevance 1.87 Pain Relevance 0.81
Similar to the mRNA results, treatment with LG268 or rosiglitazone alone resulted in equivalent decreases in IL-1?
Positive_regulation (resulted) of Negative_regulation (decreases) of IL-1
2) Confidence 0.49 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
B activation participates in the IL-1-mediated downregulation of PPAR?
Positive_regulation (participates) of Negative_regulation (downregulation) of IL-1-mediated
3) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.37 Pain Relevance 0.15
-induced cartilage breakdown by inhibiting the IL-1?
Positive_regulation (induced) of Negative_regulation (inhibiting) of IL-1 in cartilage
4) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.92 Pain Relevance 0.54
CRP secretion is increased in response to a complex network of cytokines, especially IL-6 and either IL-1 or tumor necrosis factor (TNF-?)
Positive_regulation (response) of Negative_regulation (network) of IL-1 associated with necrosis, cancer and cytokine
5) Confidence 0.14 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC2989710 Disease Relevance 1.31 Pain Relevance 0.22
to type II sIL-1R by approximately 100-fold, while leaving unaltered the low binding affinity of IL-1Ra to type II sIL-1R, thus enhancing inhibition of IL-1 when both IL-1Ra and sIL-1RAcP are present [52].
Positive_regulation (enhancing) of Negative_regulation (inhibition) of IL-1
6) Confidence 0.10 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.24 Pain Relevance 0.10
Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug.
Positive_regulation (induced) of Negative_regulation (Inhibition) of interleukin 1 in chondrocyte associated with corticosteroid and inflammation
7) Confidence 0.05 Published 1992 Journal J. Rheumatol. Section Title Doc Link 1556675 Disease Relevance 0.18 Pain Relevance 0.18
and inhibition of IL-1 and IL-2 induced lymphocyte stimulation [reviewed in [52]].
Positive_regulation (induced) of Negative_regulation (inhibition) of IL-1 in lymphocyte
8) Confidence 0.05 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1464387 Disease Relevance 0.99 Pain Relevance 0.13
Chirayita is reported to reduce the elevated levels of IL-1?
Positive_regulation (elevated) of Negative_regulation (reduce) of IL-1
9) Confidence 0.01 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2274991 Disease Relevance 1.32 Pain Relevance 0.50

General Comments

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