INT1138

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Context Info
Confidence 0.68
First Reported 1979
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 5.59
Pain Relevance 8.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mesangium 2
spinal 1
saliva 1
IgG-2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 12 99.92 Very High Very High Very High
Neuritis 17 99.86 Very High Very High Very High
methadone 12 99.44 Very High Very High Very High
Morphine 34 99.36 Very High Very High Very High
alcohol 12 99.30 Very High Very High Very High
intrathecal 22 98.08 Very High Very High Very High
cINOD 4 97.64 Very High Very High Very High
anesthesia 2 95.96 Very High Very High Very High
imagery 11 94.08 High High
ketamine 1 92.32 High High
Disease Link Frequency Relevance Heat
Sleep Disorders 1 99.92 Very High Very High Very High
Experimental Autoimmune Neuritis 12 99.86 Very High Very High Very High
Leukocytosis 1 99.66 Very High Very High Very High
Disease 9 99.46 Very High Very High Very High
Congenital Anomalies 3 99.10 Very High Very High Very High
Meningoencephalitis 12 98.32 Very High Very High Very High
Body Weight 4 98.00 Very High Very High Very High
Rhinitis 11 97.92 Very High Very High Very High
Pressure And Volume Under Development 5 93.92 High High
Lumbar Puncture Related Headaches 6 93.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This specific immunotoxic effect was corroborated by an increased IgG concentration in serum (significant for the methadone-treated group).
Positive_regulation (increased) of IgG associated with methadone
1) Confidence 0.68 Published 1995 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 7499032 Disease Relevance 0.37 Pain Relevance 0.96
In vivo studies indicated that morphine-treated rats had a higher (P < 0.05) accumulation of aggregated human IgG complexes (125I-labeled ahIgG) in their glomeruli when compared with untreated rats (control rats, 256,929 +/- 40,008 cpm/g protein vs. experimental rats, 398,317 + 51,512 cpm/g).
Positive_regulation (accumulation) of IgG associated with morphine
2) Confidence 0.57 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8498540 Disease Relevance 0.05 Pain Relevance 1.03
Total immunoglobulin A concentrations in serum were significantly decreased in the highest dose group, whereas IgG concentrations were increased, albeit not statistically significantly.
Positive_regulation (increased) of IgG
3) Confidence 0.17 Published 1994 Journal Lab. Anim. Section Abstract Doc Link 7830376 Disease Relevance 0.19 Pain Relevance 0.13
But at an earlier time (4 hr) alcohol enhanced the effect of cocaine on accumulation of IgG aggregates into the mesangium.
Positive_regulation (accumulation) of IgG in mesangium associated with cocaine and alcohol
4) Confidence 0.14 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115348 Disease Relevance 0.13 Pain Relevance 1.08
Twenty of the 75 patients (27%) had valvular disease and 12 of these (60%) had increased concentrations of IgG aCL, compared with 12 of 55 (22%) without valvular disease (p less than 0.01).
Positive_regulation (increased) of IgG aCL associated with disease
5) Confidence 0.14 Published 1992 Journal Medicine (Baltimore) Section Abstract Doc Link 1518395 Disease Relevance 0.80 Pain Relevance 0.05
Therefore, we studied the effect of cocaine, alcohol, and morphine alone or in combination on the accumulation of radiolabeled human immunoglobulin-G (IgG) aggregates (AHIgG125I) into glomeruli/mesangium.
Positive_regulation (accumulation) of IgG in mesangium associated with morphine, alcohol and cocaine
6) Confidence 0.09 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115348 Disease Relevance 0.16 Pain Relevance 0.99
IgG is thought to enter saliva by paracellular leakage but did not accumulate in luminal saliva in the present study.
Neg (not) Positive_regulation (accumulate) of IgG in saliva
7) Confidence 0.08 Published 2003 Journal Exp. Physiol. Section Abstract Doc Link 12525850 Disease Relevance 0 Pain Relevance 0
Total serum IgG levels, however, were increased in high-dose methadone-treated animals.
Positive_regulation (increased) of IgG associated with methadone
8) Confidence 0.07 Published 1998 Journal Toxicology Section Abstract Doc Link 9772098 Disease Relevance 0.15 Pain Relevance 0.98
Of the nine novel AID examined, levamisole and tetramisole demonstrated considerable activity in all four tests and dapsone was especially active in the anti-IgG and RPA tests.
Positive_regulation (active) of IgG associated with cinod
9) Confidence 0.05 Published 1979 Journal Agents Actions Section Abstract Doc Link 157060 Disease Relevance 0.54 Pain Relevance 0.45
NR2B specific IgG in CSF in NR2B group could not be detected on day 1 before spinal dissection; but could be detected on day 7 after surgery.
Neg (not) Positive_regulation (detected) of IgG in spinal
10) Confidence 0.04 Published 2007 Journal Chin. Med. J. Section Body Doc Link 17517177 Disease Relevance 0.11 Pain Relevance 0
On the other hand, the secondary IgG AFC response to KLH was enhanced by 10 pmoles BEP, while the IgM and IgA AFC responses remained unaltered by BEP treatment.
Positive_regulation (enhanced) of IgG AFC
11) Confidence 0.03 Published 1989 Journal Peptides Section Abstract Doc Link 2474158 Disease Relevance 0.08 Pain Relevance 0.14
Also, in IL-10-treated EAN rats, upregulated anti-P2 IgG1 and downregulated IgG2a were observed.
Positive_regulation (upregulated) of IgG2a associated with neuritis
12) Confidence 0.01 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143372 Disease Relevance 0.99 Pain Relevance 0.97
Induction of IgG immune complex-induced alveolitis was performed as previously described [41].
Positive_regulation (Induction) of IgG
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2636885 Disease Relevance 0.43 Pain Relevance 0.18
In the CSF one or more abnormalities (in 17/45 = 38% pleocytosis, in 16/45 = 36% increased IgG-index, and in 20/29 = 69% OB) was found in a total of 23/29 = 79% of patients.
Positive_regulation (increased) of IgG-index associated with congenital anomalies and leukocytosis
14) Confidence 0.01 Published 1992 Journal Acta Neurol. Scand. Section Abstract Doc Link 1414254 Disease Relevance 1.09 Pain Relevance 0.97
In our experience, IgE in the CSF and serum in eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis is the immunoglobulin that shows the largest increase compared to IgA, IgG and IgM.
Positive_regulation (increase) of IgG associated with rhinitis and meningoencephalitis
15) Confidence 0.00 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2607252 Disease Relevance 0.42 Pain Relevance 0.17
Levels of antinuclear, IgG-anticardiolipin and anti-doublestranded-DNA antibodies were excessively elevated.
Positive_regulation (elevated) of IgG-anticardiolipin
16) Confidence 0.00 Published 2002 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 12098096 Disease Relevance 0.09 Pain Relevance 0

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