INT11380

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2011
Negated 4
Speculated 3
Reported most in Abstract
Documents 215
Total Number 218
Disease Relevance 125.62
Pain Relevance 72.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 11
cartilage 7
chondrocytes 5
macrophage 3
neutrophil 3
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2567 100.00 Very High Very High Very High
cytokine 1945 100.00 Very High Very High Very High
rheumatoid arthritis 1124 100.00 Very High Very High Very High
metalloproteinase 512 100.00 Very High Very High Very High
endometriosis 340 100.00 Very High Very High Very High
aspirin 110 100.00 Very High Very High Very High
Inflammatory mediators 95 100.00 Very High Very High Very High
COX-2 inhibitor 75 100.00 Very High Very High Very High
methotrexate 254 99.98 Very High Very High Very High
cINOD 303 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2854 100.00 Very High Very High Very High
Rheumatoid Arthritis 1443 100.00 Very High Very High Very High
Cancer 505 100.00 Very High Very High Very High
Endometriosis 448 100.00 Very High Very High Very High
Necrosis 202 100.00 Very High Very High Very High
Repression 31 100.00 Very High Very High Very High
Brain Injury 22 100.00 Very High Very High Very High
Solid Tumor 10 99.98 Very High Very High Very High
Hyperalgesia 19 99.92 Very High Very High Very High
Arthritis 855 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methotrexate inhibited IL-1 activity without affecting IL-1 production.
Negative_regulation (inhibited) of IL-1 associated with methotrexate
1) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.24 Pain Relevance 0.40
Gold compounds inhibited IL-1 activity, but only auranofin inhibited IL-1 production.
Negative_regulation (inhibited) of IL-1
2) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.22 Pain Relevance 0.39
D-penicillamine inhibited IL-1 activity and tended to inhibit IL-1 production.
Negative_regulation (inhibited) of IL-1
3) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.23 Pain Relevance 0.39
The objective of our study was to investigate the effect of a number of representative antirheumatic agents on the activity of IL-1 and the production of both IL-1 and IL-1 inhibitor by human monocytes.
Negative_regulation (inhibitor) of IL-1 in monocytes
4) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.25 Pain Relevance 0.27
High concentrations of indomethacin, aspirin, and 12 other nonsteroidal antiinflammatory drugs (NSAID) inhibited IL-1 activity, or production or both.
Negative_regulation (inhibited) of IL-1 associated with aspirin, inflammation and cinod
5) Confidence 0.59 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.25 Pain Relevance 0.40
D-Penicillamine (up to 6 mM), cyclosporin A (up to 1 microM) and methotrexate (up to 12 microM) inhibited neither cell-associated nor secreted IL-1 beta levels.
Negative_regulation (inhibited) of IL-1 beta associated with methotrexate
6) Confidence 0.58 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.09 Pain Relevance 0.27
As expected, hydrocortisone demonstrated a marked decrease on IL-1 alpha and IL-1 beta, both in the presence and absence of LPS.
Negative_regulation (decrease) of IL-1 beta
7) Confidence 0.58 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456629 Disease Relevance 0.13 Pain Relevance 0.27
Exposure of monocytes to SKF86002 for > 2 hr led to a loss of IL-1 beta inhibitory activity, suggesting that these cells adapted to this agent.
Negative_regulation (loss) of IL-1 in monocytes
8) Confidence 0.57 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7565623 Disease Relevance 0.25 Pain Relevance 0.31
IL-18 immunoneutralization resulted in a 60-80% reduction of IL-1beta, IL-8, IFN-gamma, and TNF-alpha release from LPS-stimulated monocytes.
Negative_regulation (reduction) of IL-1beta in monocytes
9) Confidence 0.57 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.31
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Negative_regulation (inhibition) of IL-1beta in monocytes
10) Confidence 0.57 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.37
IL-1beta levels decreased at all times compared with the baseline value in the control group.
Negative_regulation (decreased) of IL-1beta
11) Confidence 0.57 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 10825337 Disease Relevance 0.44 Pain Relevance 0.68
ChIP results (Figures 6 and 7), suggest that rosiglitazone and LG268 may be inhibiting the IL-1?
Negative_regulation (inhibiting) of IL-1
12) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.13 Pain Relevance 0.03
Similar to the mRNA results, treatment with LG268 or rosiglitazone alone resulted in equivalent decreases in IL-1?
Negative_regulation (decreases) of IL-1
13) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
ligands extends to the inhibition of IL-1?
Negative_regulation (inhibition) of IL-1
14) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.36 Pain Relevance 0.14
As expected, hydrocortisone demonstrated a marked decrease on IL-1 alpha and IL-1 beta, both in the presence and absence of LPS.
Negative_regulation (decrease) of IL-1
15) Confidence 0.57 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456629 Disease Relevance 0.13 Pain Relevance 0.27
A significant reduction in cytokine levels (interleukin-1beta and prostaglandin E2, which are associated with destructive changes in inflamed tissues and bone resorption also occurs.
Negative_regulation (reduction) of interleukin-1beta associated with hypercalcemia and cytokine
16) Confidence 0.57 Published 2001 Journal Periodontol. 2000 Section Abstract Doc Link 11155183 Disease Relevance 0.79 Pain Relevance 0.09
Reducing IL-1beta and IL-18 production by inhibition of IL-1beta converting enzyme (ICE, caspase-1) is one promising strategy because of the key roles of these cytokines in many inflammatory diseases.
Negative_regulation (inhibition) of IL-1beta associated with inflammation, disease and cytokine
17) Confidence 0.57 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772244 Disease Relevance 0.50 Pain Relevance 0.49
Significant inhibition of IL-1?
Negative_regulation (inhibition) of IL-1
18) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.20 Pain Relevance 0.17
Taken together, the evidence presented in the current review showing the importance of IL-1beta in animal and human pain states, suggests that blockade of IL-1beta be considered as a therapeutic opportunity.
Negative_regulation (blockade) of IL-1beta associated with pain
19) Confidence 0.57 Published 2009 Journal Brain research reviews Section Abstract Doc Link 19166877 Disease Relevance 1.02 Pain Relevance 0.86
Accordingly, PGE(2) at sufficiently high plasma concentrations enhances cellular survival by inhibiting pro-inflammatory cytokines such as TNF-alpha and IL-1beta.
Negative_regulation (inhibiting) of IL-1beta in plasma associated with inflammation and cytokine
20) Confidence 0.57 Published 2002 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12495545 Disease Relevance 0.63 Pain Relevance 0.84

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