INT113802

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2d4) oxidoreductase activity (Cyp2d4) endoplasmic reticulum (Cyp2d4)
cellular_component (Cyp2d4) cytoplasm (Cyp2d4)
Anatomy Link Frequency
brain 1
Cyp2d4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 1 97.24 Very High Very High Very High
fluoxetine 2 59.84 Quite High
Central nervous system 1 43.76 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rat brain microsomes, these activities were not inhibited by anti-P450c21 antibodies, but they were effectively inhibited by the CYP2D-specific chemical inhibitor quinidine and by anti-CYP2D4 antibodies. mRNA and protein of CYP2D4 were expressed throughout the brain, especially in cerebellum, striatum, pons, and medulla oblongata, whereas the mRNA and protein levels of P450c21 were extremely low or undetectable.
Transcription (expressed) of CYP2D4 in brain associated with medulla
1) Confidence 0.69 Published 2004 Journal Endocrinology Section Abstract Doc Link 14563706 Disease Relevance 0 Pain Relevance 0.11

General Comments

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