INT113806

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.75
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
hearts 4
Stage 11 2
brain 1
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 16 100.00 Very High Very High Very High
Cannabinoid 118 99.70 Very High Very High Very High
cannabis 81 92.00 High High
Delta-9-tetrahydrocannabinol 23 56.52 Quite High
cocaine 2 54.88 Quite High
Inflammation 20 54.00 Quite High
opiate 4 52.08 Quite High
alcohol 6 50.88 Quite High
Opioid 5 49.36 Quite Low
medulla 1 33.84 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 35 99.72 Very High Very High Very High
Hypoxia 8 85.68 High High
Ganglion Cysts 4 85.44 High High
Nicotine Addiction 10 84.96 Quite High
Disease 94 84.88 Quite High
Cancer 17 82.48 Quite High
Sprains And Strains 1 82.12 Quite High
Myocardial Infarction 36 80.00 Quite High
Eye Disease 42 72.08 Quite High
Congenital Toxoplasmosis 56 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA of cytochrome P450 21-hydroxylase (P450c21) is expressed in the brain, but little is known about the enzymatic properties of P450c21 in the brain.
Transcription (expressed) of P450 in brain
1) Confidence 0.67 Published 2004 Journal Endocrinology Section Abstract Doc Link 14563706 Disease Relevance 0 Pain Relevance 0
For all three cytochromes P450, methadone N-demethylation was best described by two-site enzyme models with competitive inhibition.
Transcription (described) of cytochromes P450 associated with methadone
2) Confidence 0.60 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17259447 Disease Relevance 0 Pain Relevance 1.07
It is noteworthy that CYP2C9 and CYP2B6 mRNAs were only detected in a small number of hearts.
Transcription (detected) of CYP2B6 in hearts
3) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.22 Pain Relevance 0
CYP4A11, CYP2E1, CYP1A1 and CYP2C8 mRNAs were present at an intermediate level while CYP2B6 and CYP2C9 mRNAs were present at very low levels in some of the analyzed hearts.


Transcription (present) of CYP2B6 in hearts
4) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.08 Pain Relevance 0
When information is available, it is based on a small number (often <10) of explanted hearts from subjects with various conditions.[10], [11], [12], [13] For instance, Thum and Borlak report the presence of CYP1A1, CYP2B6, CYP2C8, CYP2C19, CYP2D6 and CYP4B1 mRNAs in seven explanted hearts.
Transcription (presence) of CYP2B6 in hearts
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.19 Pain Relevance 0.03
Other CYP450 mRNAs of importance were CYP4A11, CYP2E1, CYP1A1 and CYP2C8 mRNAs while CYP2B6 and CYP2C9 mRNAs were present at low levels in only some of the hearts analyzed.
Transcription (present) of CYP2B6 in hearts
6) Confidence 0.41 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001885 Disease Relevance 0.08 Pain Relevance 0
Does avoidance of the P-450 system reduce the potential for unwanted drug-drug interactions in real world settings?
Transcription (avoidance) of P-450
7) Confidence 0.21 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770423 Disease Relevance 0.10 Pain Relevance 0
Even though cannabinoids stimulate the transcription of P450 (2A and 3C), they also directly inhibit the activity of this enzyme [101].
Transcription (transcription) of P450 associated with cannabinoid
8) Confidence 0.02 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC1261530 Disease Relevance 0.25 Pain Relevance 0.63
In the mouse eye, transcripts for types IIA and IIB mRNA have been detected during embryogenesis starting at least from day 10.5 (equivalent to Carnegie Stage 11; ?
Transcription (detected) of IIB in Stage 11
9) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.42 Pain Relevance 0
In the mouse eye, transcripts for types IIA and IIB mRNA have been detected during embryogenesis starting at least from day 10.5 (equivalent to Carnegie Stage 11; ?
Transcription (transcripts) of IIB in Stage 11
10) Confidence 0.01 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.42 Pain Relevance 0

General Comments

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