INT11381

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2011
Negated 20
Speculated 15
Reported most in Abstract
Documents 330
Total Number 345
Disease Relevance 209.31
Pain Relevance 100.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 16
chondrocytes 9
macrophages 6
cartilage 6
plasma 5
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4053 100.00 Very High Very High Very High
cytokine 3424 100.00 Very High Very High Very High
antagonist 659 100.00 Very High Very High Very High
chemokine 518 100.00 Very High Very High Very High
cINOD 187 100.00 Very High Very High Very High
Inflammatory mediators 121 100.00 Very High Very High Very High
aspirin 102 100.00 Very High Very High Very High
Inflammatory stimuli 61 100.00 Very High Very High Very High
COX2 43 100.00 Very High Very High Very High
agonist 825 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4575 100.00 Very High Very High Very High
Disease 2452 100.00 Very High Very High Very High
Cancer 588 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 507 100.00 Very High Very High Very High
Necrosis 290 100.00 Very High Very High Very High
Adhesions 224 100.00 Very High Very High Very High
Acute-phase Reaction 69 100.00 Very High Very High Very High
Infection 807 99.98 Very High Very High Very High
Herpes Simplex Virus 253 99.98 Very High Very High Very High
Rheumatoid Arthritis 1611 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Escherichia coli lipopolysaccharide stimulation of monocytes induced rapid IL1-beta mRNA accumulation, reaching a maximum at 2 to 4 h and declining thereafter.
Positive_regulation (accumulation) of IL1-beta in monocytes
1) Confidence 0.70 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.14 Pain Relevance 0.08
Because IL1-beta has also been implicated in the inflammatory and fibrotic responses in pulmonary sarcoidosis, 4 patients with newly diagnosed sarcoidosis underwent bronchoalveolar lavage, and IL1-beta mRNA accumulation was compared in their alveolar macrophages and blood monocytes.
Positive_regulation (accumulation) of IL1-beta in monocytes associated with pulmonary sarcoidosis, fibrosis, inflammation and sarcoidosis
2) Confidence 0.70 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.72 Pain Relevance 0.12
Comparing normal alveolar macrophages to those from patients with sarcoidosis showed no differences in the kinetics of IL1-beta mRNA expression or in the LPS-induced levels of IL1-beta mRNA accumulation.
Positive_regulation (accumulation) of IL1-beta in alveolar macrophages associated with sarcoidosis
3) Confidence 0.70 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.66 Pain Relevance 0.10
To assess the ability of human alveolar macrophages to produce interleukin-1-beta (IL1-beta), we examined IL1-beta mRNA accumulation in autologous monocytes and alveolar macrophages from normal volunteers.
Spec (examined) Positive_regulation (accumulation) of IL1-beta in monocytes
4) Confidence 0.70 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.13 Pain Relevance 0.06
After this culture period, monocytes had a marked decrease in the ability to accumulate IL1-beta mRNA, suggesting that cell aging may be one mechanism involved in producing these transcriptional differences.
Positive_regulation (accumulate) of IL1-beta in monocytes associated with aging
5) Confidence 0.70 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.66 Pain Relevance 0.13
Therefore, IL1B -31C>T is an important candidate polymorphism that may influence the susceptibility or resistance to cerebral malaria through the upregulation of IL-1?.
Positive_regulation (upregulation) of IL-1 associated with cerebral malaria
6) Confidence 0.69 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.66 Pain Relevance 0
Reduced elevation of postoperative IL-1 and effective pain relief may both contribute to an attenuated illness response and a better surgery outcome.
Positive_regulation (elevation) of IL-1 associated with pain
7) Confidence 0.69 Published 2006 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040817 Disease Relevance 0.73 Pain Relevance 0.83
Another series of human studies describes an interaction between the effectiveness of postoperative pain relief and surgery-associated immune alterations: In three separate studies, the more effective pain management technique was associated with diminished surgery-induced immune alterations, especially diminished elevation of IL-1.
Positive_regulation (elevation) of IL-1 associated with pain management and perioperative pain
8) Confidence 0.69 Published 2006 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18040817 Disease Relevance 0.74 Pain Relevance 0.84
Consistent with this is that the IL-1RN*2 allele is associated with a higher production of inflammatory reactions, and therefore, an overall increase of IL-1 activity, meaning less effective IL-1ra inhibitory activity [19,27].
Positive_regulation (increase) of IL-1 associated with inflammation
9) Confidence 0.67 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.19 Pain Relevance 0.05
In this respect, the profile of systemic cytokines' changes in response to exercise differs from that observed in sepsis, where there is a relevant increase in both serum IL-1?
Positive_regulation (increase) of IL-1 associated with sepsis and cytokine
10) Confidence 0.67 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 1.16 Pain Relevance 0.34
after exercise, there is evidence of increased local IL-1?
Positive_regulation (increased) of IL-1
11) Confidence 0.67 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.67 Pain Relevance 0.19
CONCLUSIONS: This study indicates that a major musculoskeletal trauma principally is followed by significant increases in systemic levels of IL-6 with only modest systemic reactions in TNFalpha and IL-1beta, even in patients with an inflammatory disease.
Positive_regulation (increases) of IL-1beta
12) Confidence 0.67 Published 2009 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 18946778 Disease Relevance 0.07 Pain Relevance 0
Serum concentrations of IL-1beta, TNF-alpha, IL-2 and IL-4 were increased but as we adjusted the level of significance at p = 0.0045, most cytokine plasma levels failed to reach statistical significance.
Positive_regulation (increased) of IL-1beta in plasma
13) Confidence 0.67 Published 2007 Journal Inflamm. Res. Section Body Doc Link 17334668 Disease Relevance 0.14 Pain Relevance 0
Eradication of H. pylori decreases IL-1beta induction, resulting in an increase in gastric juice acidity and normalization of serum gastrin levels.
Positive_regulation (induction) of IL-1beta in gastric juice
14) Confidence 0.67 Published 1999 Journal J. Gastroenterol. Section Abstract Doc Link 10616759 Disease Relevance 0.46 Pain Relevance 0.07
These results suggest that H. pylori infection induces IL-1beta and suppresses acid secretion, resulting in increases in gastric juice pH and serum gastrin levels.
Positive_regulation (induces) of IL-1beta in gastric juice associated with infection
15) Confidence 0.67 Published 1999 Journal J. Gastroenterol. Section Abstract Doc Link 10616759 Disease Relevance 0.50 Pain Relevance 0.07
Although both desArg(10)KD and BK increased the level of IL-1beta mRNA, IL-1beta receptor antagonist inhibited the increase in B1R only in response to BK.
Positive_regulation (increased) of IL-1beta associated with antagonist and bradykinin
16) Confidence 0.67 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.22 Pain Relevance 0.84
These data suggest that 1) IL-1beta mRNA upregulation in the brain may be relevant to the anorexia exhibited by the tumor-bearing Lobund-Wistar rat and 2) in vivo characterization of cytokine components in discrete brain regions during cancer is necessary to understand underlying molecular mechanisms responsible for cancer-associated neurological manifestations.
Positive_regulation (upregulation) of IL-1beta in brain associated with appetite loss, cancer, neurologic manifestations and cytokine
17) Confidence 0.67 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9688694 Disease Relevance 1.39 Pain Relevance 0.36
IL-1beta mRNA and IL-1Ra mRNA were also significantly upregulated in the spleen of tumor-bearing rats.
Positive_regulation (upregulated) of IL-1beta in spleen associated with cancer
18) Confidence 0.67 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9688694 Disease Relevance 1.39 Pain Relevance 0.40
The data show that early anorexia in tumor-bearing rats was associated with an upregulation of IL-1beta mRNA in the brain regions examined (cerebellum, cortex, and hypothalamus).
Positive_regulation (upregulation) of IL-1beta in brain associated with appetite loss and cancer
19) Confidence 0.67 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9688694 Disease Relevance 1.54 Pain Relevance 0.41
Serum levels of proinflammatory cytokines (interleukin-1beta, interleukin-6 and tumour necrosis factor-alpha), but not their soluble receptors, were significantly elevated in patients with hyperalgesia (p<0.05-0.01).
Positive_regulation (elevated) of interleukin-1beta
20) Confidence 0.67 Published 2008 Journal J. Neurol. Neurosurg. Psychiatr. Section Body Doc Link 18356256 Disease Relevance 0.17 Pain Relevance 0

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