INT113814

Context Info Confidence 0.67 First Reported 2003 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.45 Pain Relevance 0.66

cell proliferation (REG1B) extracellular region (REG1B)

Anatomy Link Frequency pancreas 1 stomach 1 REG1B (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 12 95.84 anesthesia 1 93.20 methotrexate 1 82.40 cINOD 2 76.96 Crohn's disease 1 40.48 Neuropeptide 2 25.00 Chronic pancreatitis 1 5.00

Disease Link Frequency Relevance Heat Pancreatitis 2 98.56 Stress 1 94.32 Cancer 51 92.48 Pancreatic Cancer 32 81.72 Injury 10 77.56 INFLAMMATION 2 76.76 Sepsis 1 75.00 Metastasis 4 65.20 Stomach Cancer 2 60.32 Congenital Anomalies 4 53.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A time course analysis of RegI expression during the onset and offset of adaptation showed that mucosal RegI increased during the development of adaptation, was maintained during subsequent aspirin dosing, and returned to baseline levels once dosing had ceased and adaptation was lost-indicative of a causal role in the adaptation process.

Gene_expression (expression) of RegI associated with aspirin

1) Confidence 0.67 Published 2003 Journal Lab. Invest. Section Abstract Doc Link 14563943 Disease Relevance 0.29 Pain Relevance 0.28

TFF gene and protein expression levels were similar in all three groups, whereas RegI gene expression and protein levels in adapted stomach were increased.

Gene_expression (expression) of RegI in stomach

2) Confidence 0.67 Published 2003 Journal Lab. Invest. Section Abstract Doc Link 14563943 Disease Relevance 0.30 Pain Relevance 0.25

Contrary to reg1A, reg1B, reg3A and reg3G genes, all located on chromosome 2p12, reg4 is on chromosome 1p13.1-p12.

Gene_expression (is) of reg1B

3) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.59 Pain Relevance 0.04

OBJECTIVES: The level of pancreatic stone protein/regenerating protein (PSP/reg), a secretory protein produced in the pancreas, increases dramatically during pancreatic disease.

Gene_expression (produced) of pancreatic stone protein in pancreas associated with pancreatitis

4) Confidence 0.28 Published 2009 Journal Crit. Care Med. Section Abstract Doc Link 19325491 Disease Relevance 0.27 Pain Relevance 0.09

General Comments

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