INT113834

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Context Info
Confidence 0.03
First Reported 2003
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.71
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gatm) embryo development (Gatm) cellular_component (Gatm)
cytoplasm (Gatm)
Anatomy Link Frequency
macrophages 1
CPA 1
gray matter 1
Gatm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 2 99.40 Very High Very High Very High
Central grey 1 98.00 Very High Very High Very High
Morphine 6 95.52 Very High Very High Very High
withdrawal 7 95.16 Very High Very High Very High
Bioavailability 3 94.56 High High
addiction 3 90.56 High High
cva 9 73.84 Quite High
Neurotransmitter 2 70.92 Quite High
narcan 4 67.92 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 98.00 Very High Very High Very High
Hemorrhage 9 73.84 Quite High
Aplasia 6 73.20 Quite High
Thrombocytopenia 9 72.84 Quite High
Hematological Disease 12 69.20 Quite High
Hepatotoxicity 3 48.24 Quite Low
Hyperplasia 3 15.16 Low Low
INFLAMMATION 15 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the optimized condition of amino acid derivatization, we investigated the changes in L-arginine (L-Arg) and L-glutamate (L-Glu) concentration in periaqueductal gray matter (PAG) microdialytes of free-moving morphine-withdrawal rats.
Spec (investigated) Regulation (changes) of L-arginine in gray matter associated with glutamate, urological neuroanatomy, withdrawal, central grey and morphine
1) Confidence 0.03 Published 2003 Journal Sheng Li Xue Bao Section Abstract Doc Link 14566413 Disease Relevance 0.42 Pain Relevance 0.62
Although, the unique and relatively potent inhibition of arginase by the biosynthetic intermediate in NO generation, NG-hydroxy-L-arginine suggests an alternate means of regulation in tissues and cells (such as macrophages), that contain both NOS and arginase [35].
Regulation (regulation) of L-arginine in macrophages
2) Confidence 0.01 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0.05
Indeed, in our study in vitro tactivation and inhibition of distinct NOSs are highly depended on concentrations of calcium, L-arginine and NOS cofactors, and a chelator agent EDTA, as well.
Regulation (depended) of L-arginine
3) Confidence 0.01 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0 Pain Relevance 0.05
L-arginine and NOS cofactors affect in vitro the activity of distinct NOS isoforms of marrow and blood platelet and leucocyte subpopulations from control and CPA treated rats suggesting the involvement of L-arginine metabolic pathways, as well as pro-oxidant system, including NADPH oxidase in the regulation of nitrergic response of marrow and blood.
Regulation (affect) of L-arginine in CPA
4) Confidence 0.01 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.29 Pain Relevance 0.04

General Comments

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