INT113840

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Context Info
Confidence 0.58
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.23
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
leukocytes 2
adipocytes 2
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 2 99.98 Very High Very High Very High
opioid receptor 1 98.52 Very High Very High Very High
cINOD 10 97.48 Very High Very High Very High
withdrawal 1 90.16 High High
agonist 35 76.20 Quite High
antagonist 4 54.00 Quite High
Inflammation 31 51.60 Quite High
COX2 2 25.00 Low Low
cOX1 2 25.00 Low Low
cytokine 17 10.00 Low Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 10 98.46 Very High Very High Very High
INFLAMMATION 39 98.44 Very High Very High Very High
Obesity 21 97.78 Very High Very High Very High
Hyperplasia 21 95.92 Very High Very High Very High
Cancer 58 95.12 Very High Very High Very High
Repression 2 88.24 High High
Stress 22 77.60 Quite High
Death 82 75.04 Quite High
Carcinoma 2 75.00 Quite High
Apoptosis 65 74.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It resulted in an inhibition of AP-1-driven reporter gene activity and of the expression of the AP-1 target gene interleukin-3.
Negative_regulation (inhibition) of Gene_expression (expression) of AP-1
1) Confidence 0.58 Published 2004 Journal Anesthesiology Section Body Doc Link 15329596 Disease Relevance 0 Pain Relevance 0
Piroxicam selectively inhibits the growth of premalignant and malignant human oral cell lines by limiting their progression through the S phase and reducing the levels of cyclins and AP-1.
Negative_regulation (reducing) of Gene_expression (levels) of AP-1 associated with malignant neoplastic disease
2) Confidence 0.42 Published 2003 Journal Int. J. Cancer Section Title Doc Link 14566835 Disease Relevance 0.60 Pain Relevance 0.10
Morphine inhibits AP-1 activity and CD14 expression in leukocytes by a nitric oxide and opioid receptor-dependent mechanism.
Negative_regulation (inhibits) of Gene_expression (expression) of AP-1 in leukocytes associated with opioid receptor and morphine
3) Confidence 0.37 Published 2007 Journal Eur J Anaesthesiol Section Title Doc Link 17583593 Disease Relevance 0 Pain Relevance 0.24
After 1 h exposure to L. plantarum WCFS1, four major transcriptional regulators were all found to be downregulated: the oncogene product MYC (c-Myc), FOS (c-Fos), JUN (c-Jun) and the p65 subunit of the NF-?
Negative_regulation (downregulated) of Gene_expression (product) of c-Jun
4) Confidence 0.18 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.72 Pain Relevance 0
After 1 h exposure to L. plantarum WCFS1, four major transcriptional regulators were all found to be downregulated: the oncogene product MYC (c-Myc), FOS (c-Fos), JUN (c-Jun) and the p65 subunit of the NF-?
Negative_regulation (downregulated) of Gene_expression (subunit) of JUN
5) Confidence 0.18 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.78 Pain Relevance 0.03
After 1 h exposure to L. plantarum WCFS1, four major transcriptional regulators were all found to be downregulated: the oncogene product MYC (c-Myc), FOS (c-Fos), JUN (c-Jun) and the p65 subunit of the NF-?
Negative_regulation (downregulated) of Gene_expression (product) of JUN
6) Confidence 0.18 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.72 Pain Relevance 0
After 1 h exposure to L. plantarum WCFS1, four major transcriptional regulators were all found to be downregulated: the oncogene product MYC (c-Myc), FOS (c-Fos), JUN (c-Jun) and the p65 subunit of the NF-?
Negative_regulation (downregulated) of Gene_expression (subunit) of c-Jun
7) Confidence 0.18 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.78 Pain Relevance 0.03
For example, as adipocytes differentiate, they progressively become less responsive to mitogenic growth factors MIX and PDGF, eventually repressing the expression of proto-oncogenes c-jun and junB [141, 142].
Negative_regulation (repressing) of Gene_expression (expression) of c-jun in adipocytes associated with obesity
8) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.74 Pain Relevance 0.05
In addition, PGE(2) and butaprost increased c-Fos expression and activator protein 1 (AP-1) transcriptional activity, which were abolished by the mitogen-activated protein kinase/Erk kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)-butadiene ethanolate (U0126).
Negative_regulation (abolished) of Gene_expression (expression) of AP-1
9) Confidence 0.02 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.45 Pain Relevance 0.07
In addition, PGE(2) and butaprost increased c-Fos expression and activator protein 1 (AP-1) transcriptional activity, which were abolished by the mitogen-activated protein kinase/Erk kinase inhibitor 1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)-butadiene ethanolate (U0126).
Negative_regulation (abolished) of Gene_expression (expression) of activator protein 1
10) Confidence 0.02 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.45 Pain Relevance 0.07

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