INT113841

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 3.46
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNB1) protein complex assembly (CCNB1) cytoplasm (CCNB1)
cytosol (CCNB1) nucleus (CCNB1) cytoskeleton (CCNB1)
Anatomy Link Frequency
synovial cells 3
UM-UC-3 1
CCNB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 3 90.48 High High
Snapping jaw 5 84.88 Quite High
Arthritis 318 78.80 Quite High
Pain 8 76.56 Quite High
cINOD 9 60.32 Quite High
methotrexate 18 25.04 Quite Low
COX2 1 10.00 Low Low
Inflammation 87 6.40 Low Low
cytokine 51 5.36 Low Low
dexamethasone 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 28 99.56 Very High Very High Very High
Cancer 160 93.08 High High
Malignant Neoplastic Disease 13 92.04 High High
Contagious Ecthyma 1 88.48 High High
Recurrence 1 86.96 High High
Metastasis 1 85.84 High High
Temporomandibular Joint Syndrome 5 84.88 Quite High
Polyploidy 48 84.44 Quite High
Apoptosis 61 83.32 Quite High
Aneuploidy 132 82.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunohistochemical analysis of the expression of Ki-67 and Cyclin B1 proteins (cellular proliferation markers) revealed a very low proliferative cell index.
Gene_expression (expression) of Cyclin B1 associated with hyperplasia
1) Confidence 0.75 Published 2009 Journal J Orofac Pain Section Abstract Doc Link 19639107 Disease Relevance 1.53 Pain Relevance 0.49
RESULTS: Celecoxib inhibited growth of RT-4 and UM-UC-3, with G(1) cell cycle arrest and altered cyclin B1/D1 expression in RT-4, whereas Rb up-regulation occurred in UM-UC-3.
Gene_expression (expression) of cyclin B1 in UM-UC-3
2) Confidence 0.75 Published 2009 Journal Anticancer Res. Section Body Doc Link 19846907 Disease Relevance 0.08 Pain Relevance 0
It has been shown in vitro [98] that in synovial cells, the over-expression of CCNB1 and CDC2 leads to aberrant mitosis, recognizable by abundant cytoplasm, large pale nuclei and prominent nucleoli with karyotypic alteration.
Gene_expression (expression) of CCNB1 in synovial cells
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.28 Pain Relevance 0.10
It has been shown in vitro [98] that in synovial cells, the over-expression of CCNB1 and CDC2 leads to aberrant mitosis, recognizable by abundant cytoplasm, large pale nuclei and prominent nucleoli with karyotypic alteration.
Gene_expression (over) of CCNB1 in synovial cells
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.28 Pain Relevance 0.10
It has been shown in vitro [98] that in synovial cells, the over-expression of CCNB1 and CDC2 leads to aberrant mitosis, recognizable by abundant cytoplasm, large pale nuclei and prominent nucleoli with karyotypic alteration.
Gene_expression (-) of CCNB1 in synovial cells
5) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.28 Pain Relevance 0.10
The S phase block was accompanied by a reduction in the protein levels of cyclin A, cyclin B1, cyclin D1, cdc2, PCNA and the c-jun AP-1 component.
Gene_expression (levels) of cyclin B1
6) Confidence 0.41 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566835 Disease Relevance 0.53 Pain Relevance 0.06
, cyclin B1 expression and Cdc2 kinase activity were assessed by immunoblot analysis and in vitro kinase assay, respectively.
Gene_expression (expression) of cyclin B1
7) Confidence 0.28 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
treatment of HEK cells stably expressing the human FP prostanoid receptor increases expression of cyclin B1 (A) and increases Cdc2-mediated phosphorylation of histone H1 (B).
Gene_expression (expression) of cyclin B1
8) Confidence 0.28 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
These data indicate that the delay in G2/M was not due to a decrease in cyclin B1 protein expression.
Gene_expression (expression) of cyclin B1
9) Confidence 0.28 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
Blots were probed with anti-cyclin B1 and anti-actin antibodies as described in Materials and methods.
Gene_expression (probed) of anti-cyclin B1
10) Confidence 0.24 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
Surprisingly, as shown in figure 3A, cyclin B1 protein expression was found to increase following treatment of hFP-HEK cells with PGF2?.
Gene_expression (expression) of cyclin B1
11) Confidence 0.24 Published 2005 Journal Cell Mol Life Sci Section Body Doc Link PMC2792351 Disease Relevance 0 Pain Relevance 0
delays mitosis and is associated with an increased expression of cyclin B1 and Cdc2 kinase activity.
Gene_expression (expression) of cyclin B1
12) Confidence 0.22 Published 2005 Journal Cell Mol Life Sci Section Abstract Doc Link PMC2792351 Disease Relevance 0.41 Pain Relevance 0
Both NF-Y and E2F have been shown to be crucial regulators of the cell-cycle-dependent expression of several genes such as cdc2, CDC25, cyclin E, cyclin A, cyclin B, topoisomerase II?
Gene_expression (expression) of cyclin B
13) Confidence 0.03 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1072800 Disease Relevance 0.09 Pain Relevance 0

General Comments

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