INT113844

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.18
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN1A, CDK2) cytoplasm (CDKN1A, CDK2) cytosol (CDKN1A, CDK2)
nucleus (CDKN1A, CDK2) cell cycle (CDKN1A, CDK2) kinase activity (CDKN1A, CDK2)
CDKN1A (Homo sapiens)
CDK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 33 91.88 High High
COX-2 inhibitor 52 52.72 Quite High
antagonist 5 11.00 Low Low
Inflammation 28 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 177 88.88 High High
Cancer 152 79.76 Quite High
Retinoblastoma 2 75.40 Quite High
INFLAMMATION 32 75.00 Quite High
Neuroendocrine Cancer 2 75.00 Quite High
Toxicity 6 58.36 Quite High
Colon Cancer 48 50.00 Quite Low
Death 32 50.00 Quite Low
Leukemia 9 8.88 Low Low
Fever 41 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we speculated that the resulting increased p21Cip1 and p27Kip1, by binding to and consequently inhibiting the cyclin E/CDK2 complex activity, potentiated the cell cycle arrest in G0/G1 phase, as also reported by others [28].
p21Cip1 Negative_regulation (inhibiting) of CDK2
1) Confidence 0.49 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2914703 Disease Relevance 0.11 Pain Relevance 0
Thus, the G1 arrest likely resulted from p21(cip-1)-dependent inhibition of CDK-2 activity.
cip-1 Negative_regulation (inhibition) of CDK-2
2) Confidence 0.41 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566837 Disease Relevance 0.36 Pain Relevance 0.59
Thus, the G1 arrest likely resulted from p21(cip-1)-dependent inhibition of CDK-2 activity.
p21 Negative_regulation (inhibition) of CDK-2
3) Confidence 0.41 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566837 Disease Relevance 0.36 Pain Relevance 0.59
In the case of DNA damages, p53 is activated and increases the level of p21 that is directly inhibiting cdk2.
p21 Negative_regulation (inhibiting) of cdk2
4) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.35 Pain Relevance 0.08

General Comments

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