INT113845

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Context Info
Confidence 0.88
First Reported 2001
Last Reported 2011
Negated 1
Speculated 1
Reported most in Abstract
Documents 54
Total Number 55
Disease Relevance 43.86
Pain Relevance 8.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
cleavage 36
poly 6
MCF-7 2
macrophages 1
chondrocytes 1
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 32 99.36 Very High Very High Very High
Paracetamol 22 98.78 Very High Very High Very High
rheumatoid arthritis 61 98.48 Very High Very High Very High
qutenza 10 97.92 Very High Very High Very High
COX-2 inhibitor 126 97.04 Very High Very High Very High
cINOD 138 94.80 High High
dexamethasone 52 94.80 High High
Inflammation 247 91.36 High High
adenocard 5 90.24 High High
Osteoarthritis 49 89.44 High High
Disease Link Frequency Relevance Heat
Apoptosis 2228 99.96 Very High Very High Very High
Death 469 99.92 Very High Very High Very High
Colon Cancer 316 99.84 Very High Very High Very High
Cancer 1218 99.28 Very High Very High Very High
Photosensitivity Disorders 2 98.80 Very High Very High Very High
Stress 231 98.66 Very High Very High Very High
Pancreatic Cancer 47 98.52 Very High Very High Very High
Rheumatoid Arthritis 63 98.48 Very High Very High Very High
Parkinson's Disease 26 98.42 Very High Very High Very High
Coronary Artery Disease 10 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The dose-dependent induction of apoptosis by ropivacaine was demonstrated by DNA fragmentation analysis and the proteolytic cleavage of a caspase-3 substrate-poly (ADP-ribose) polymerase (PARP).
Protein_catabolism (cleavage) of PARP in poly associated with apoptosis
1) Confidence 0.88 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.66 Pain Relevance 0.08
ASA and NaS at 1 mM did not induce PARP cleavage or caspase-3 and at 5 mM, ASA but not NaS increased apoptosis.
Neg (not) Protein_catabolism (cleavage) of PARP in cleavage associated with aspirin and apoptosis
2) Confidence 0.86 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.67 Pain Relevance 0.66
A pan-caspase inhibitor, z-VAD-fmk, suppressed this increase in apoptosis and also suppressed the cleavage of caspase-8, caspase-3, and PARP, suggesting a caspase-dependent mechanism.
Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
3) Confidence 0.65 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19360361 Disease Relevance 0.59 Pain Relevance 0.27
The combined nimesulide-radiation treatment increased apoptosis, induced the cleavage of caspase-3, caspase-9, and poly(ADP-ribose) polymerase (PARP), activated caspase-8, and induced cleavage of Bid.
Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
4) Confidence 0.65 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19360361 Disease Relevance 0.60 Pain Relevance 0.30
Compared with AAP treatment alone, IGF-I and AAP co-treatment increased ERK1/2 phosphorylation but inhibited PARP cleavage.
Protein_catabolism (cleavage) of PARP in cleavage associated with paracetamol
5) Confidence 0.65 Published 2007 Journal Toxicology Section Abstract Doc Link 17169476 Disease Relevance 0.46 Pain Relevance 0.85
SUL, IND, and ASA (5 mM) suppressed PPARdelta and 14-3-3 proteins in a manner parallel to PARP cleavage.
Protein_catabolism (cleavage) of PARP in cleavage associated with aspirin
6) Confidence 0.64 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.67 Pain Relevance 0.68
In HL-60 and MCF-7 cells this extract was a very strong inducer of cell death activating caspase-3 followed by PARP signature type cleavage.
Protein_catabolism (cleavage) of PARP in MCF-7 associated with death
7) Confidence 0.62 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.17 Pain Relevance 0.24
Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression.
Protein_catabolism (cleavage) of PARP in cleavage
8) Confidence 0.58 Published 2004 Journal Cell Res. Section Abstract Doc Link 15538973 Disease Relevance 0.90 Pain Relevance 0.09
m can disturb intracellular ATP synthesis, generation of reactive oxygen species (ROS), altered mitochondrial redox ratio, translocation of cyto c to the cytosol, and degradation of caspase-3/PARP[9-12].
Protein_catabolism (degradation) of PARP
9) Confidence 0.48 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.91 Pain Relevance 0
Subsequently, the presence of activated caspase-3 is further confirmed by detecting the degradation of PARP, a DNA repair enzyme, which undergoes cleavage by caspase-3 during apoptosis.
Protein_catabolism (degradation) of PARP in cleavage associated with apoptosis
10) Confidence 0.48 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.87 Pain Relevance 0.05
These results are in agreement with previous reports in that tolfenamic acid induces PARP cleavage in colorectal cancer cells [19] and pancreatic cancer cells [4].
Protein_catabolism (cleavage) of PARP in cleavage associated with pancreatic cancer and colon cancer
11) Confidence 0.47 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901767 Disease Relevance 0.82 Pain Relevance 0.07
The results showed that tolfenamic acid does not alter the expression of the COX proteins, but it inhibits cell growth and induces apoptosis as evidenced by the annexin V positivity, sub-G1 population, nuclear fragmentation and the cleavage of poly ADP-ribose polymerase.
Protein_catabolism (cleavage) of poly ADP-ribose polymerase in poly associated with apoptosis
12) Confidence 0.47 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2901767 Disease Relevance 0.74 Pain Relevance 0.31
In HuH-6 hepatoma cells the combination-induced apoptosis was associated with caspase-9 and -3 activation, PARP cleavage, release of cytochrome c from the mitochondria into the cytosol and down-regulation of survivin and beta-catenin levels.
Protein_catabolism (cleavage) of PARP in cleavage associated with hepatocellular cancer and apoptosis
13) Confidence 0.46 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.78 Pain Relevance 0.49
Our data showed that treatment of caspase-8 inhibitor could significantly suppress the cleavage of the effector caspase-7 and PARP in FR122047-treated MCF-7 cells which are caspase-3-deficient breast cancer cells, indicating that the induction of apoptosis by FR122047 is significantly dependent on caspase-8 activity in MCF-7 breast cancer cells.
Protein_catabolism (cleavage) of PARP in MCF-7 associated with breast cancer and apoptosis
14) Confidence 0.42 Published 2010 Journal Oncol. Rep. Section Abstract Doc Link 20596620 Disease Relevance 0.99 Pain Relevance 0.26
Growth and apoptosis were determined based on cell numbers, cell-cycle analyses, kinase assays, DNA fragmentation and PARP cleavage.
Spec (analyses) Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
15) Confidence 0.40 Published 2003 Journal Int. J. Cancer Section Abstract Doc Link 14566837 Disease Relevance 0.40 Pain Relevance 0.46
Importantly, apoptosis was synergistically induced by the combination treatment, as evidenced by caspase-3 activation and PARP cleavage.
Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
16) Confidence 0.37 Published 2010 Journal Mol. Carcinog. Section Abstract Doc Link 19908241 Disease Relevance 0.98 Pain Relevance 0.49
In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.
Protein_catabolism (cleavage) of PARP in cleavage
17) Confidence 0.37 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.88 Pain Relevance 0.44
These latter two agents caused no increase in the cleavage of PARP.
Protein_catabolism (cleavage) of PARP in cleavage
18) Confidence 0.36 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.06
and for cleaved PARP by western blot analysis (Figure 4c).
Protein_catabolism (cleaved) of PARP
19) Confidence 0.36 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.11
In NCTD -treated cells, the cleavage of PARP also occurred in a dose-dependent manner (Figure 6B).We could confirm that caspase-3 activity was also increased in a dose-dependentmanner (Figure 6B).
Protein_catabolism (cleavage) of PARP in cleavage
20) Confidence 0.32 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.83 Pain Relevance 0.06

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