INT11385

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.16
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (RAE1) small molecule metabolic process (RAE1) carbohydrate metabolic process (RAE1)
transmembrane transport (RAE1) cytoplasm (RAE1) RNA binding (RAE1)
Anatomy Link Frequency
granulocytes 1
synovial fluids 1
B cells 1
lymphocytes 1
RAE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 68 99.28 Very High Very High Very High
cytokine 25 98.32 Very High Very High Very High
Crohn's disease 1 86.16 High High
Arthritis 14 84.24 Quite High
Pain 6 82.16 Quite High
Inflammation 66 80.88 Quite High
metalloproteinase 2 80.32 Quite High
Osteoarthritis 1 79.68 Quite High
Analgesic 1 75.84 Quite High
psoriasis 4 61.12 Quite High
Disease Link Frequency Relevance Heat
Arthritis 16 99.50 Very High Very High Very High
Rheumatoid Arthritis 68 99.28 Very High Very High Very High
Acute-phase Reaction 1 96.32 Very High Very High Very High
INFLAMMATION 68 90.96 High High
Disease 36 90.64 High High
Systemic Lupus Erythematosus 1 88.80 High High
Hypercalcemia 1 87.56 High High
Pain 3 82.16 Quite High
Arthralgia 1 79.76 Quite High
Osteoarthritis 1 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, piroxicam inhibits both superoxide anion production and lysosomal enzyme release from human neutrophils and also inhibits IgM-rheumatoid factor production by human lymphocytes.
Gene_expression (production) of IgM-rheumatoid factor in lymphocytes
1) Confidence 0.49 Published 1983 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 6345166 Disease Relevance 0.72 Pain Relevance 0.31
Finally, IL-4 downregulates the surface expression of CD5 on B cells and inhibits spontaneous Ig and IgM rheumatoid factor production in patients with RA [77].
Gene_expression (production) of IgM rheumatoid factor in B cells associated with rheumatoid arthritis
2) Confidence 0.01 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.82 Pain Relevance 0.40
Of the laboratory parameters examined, the responders, but not the nonresponders, demonstrated significant reductions (from postwashout values) in levels of IgM rheumatoid factor and C-reactive protein (CRP), along with significant increases in the number of circulating lymphocytes and decreases in the number of circulating granulocytes (P less than or equal to 0.05).
Gene_expression (levels) of IgM rheumatoid factor in granulocytes
3) Confidence 0.00 Published 1990 Journal Arthritis Rheum. Section Abstract Doc Link 2302265 Disease Relevance 0.93 Pain Relevance 0.31
Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production.
Gene_expression (production) of IgM rheumatoid factor in synovial fluids associated with arthritis
4) Confidence 0.00 Published 1992 Journal J. Rheumatol. Section Title Doc Link 1556702 Disease Relevance 0.76 Pain Relevance 0.31
Furthermore, no correlation was found between the galactose content of IgG and serum levels of IgM rheumatoid factor or the ability of IgG to bind IgM rheumatoid factor in vitro.
Gene_expression (levels) of IgM rheumatoid factor
5) Confidence 0.00 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3358797 Disease Relevance 0.94 Pain Relevance 0.42

General Comments

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