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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.45
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) cell death (Cdkn1b) nucleus (Cdkn1b)
cell cycle (Cdkn1b) protein complex (Cdkn1b) response to stress (Cdkn1b)
Anatomy Link Frequency
colon 1
extracellular matrix 1
Cdkn1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 6 84.04 Quite High
Inflammation 9 79.92 Quite High
Pain 1 78.68 Quite High
COX-2 inhibitor 1 50.00 Quite Low
COX2 1 10.00 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 2 99.80 Very High Very High Very High
Diabetes Mellitus 100 99.76 Very High Very High Very High
Renal Disease 4 97.20 Very High Very High Very High
Cancer 2 96.80 Very High Very High Very High
Hypertrophy 2 95.28 Very High Very High Very High
Colon Cancer 8 95.16 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 1 94.48 High High
Aberrant Crypt Foci 1 91.00 High High
Diabetic Retinopathy 14 90.96 High High
Hypertension 31 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Akt-mTOR-P70S6 kinase pathway is the central regulator of cell growth and proliferation, and increases cell proliferation by inhibiting the activities of p27Kip1 and retinoblastoma protein (RB).
Negative_regulation (inhibiting) of p27Kip1 associated with retinoblastoma
1) Confidence 0.42 Published 2008 Journal Yonsei Medical Journal Section Abstract Doc Link PMC2615285 Disease Relevance 0.30 Pain Relevance 0
Inhibitors of cyclin-dependent kinases (Cdk) such as p27Kip1, a negative cell cycle regulator, are involved in the development of diabetic nephropathy, with associated mesangial hypertrophy and extracellular matrix accumulation [10-13].
Negative_regulation (Inhibitors) of p27Kip1 in extracellular matrix associated with hypertrophy and renal disease
2) Confidence 0.33 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 1.96 Pain Relevance 0
Analysis of proximal and distal colon tissue from 8- and 28-week rat/azoxymethane studies showed that GT-094 treatment reduced colon crypt proliferation by 30% to 69%, reduced inducible NO synthase (iNOS) levels by 33% to 67%, reduced poly(ADP-ribose)polymerase-1 expression and cleavage 2- to 4-fold, and elevated levels of p27 in the distal colon 3-fold.
Negative_regulation (reduced) of p27 in colon
3) Confidence 0.24 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17699720 Disease Relevance 1.11 Pain Relevance 0.60
The expression of COX-1 and COX-2. and of two cyclin dependent kinase inhibitors, p21Cip1 and p27Kip1, was analysed by Western blotting and RT-PCR.
Negative_regulation (inhibitors) of p27Kip1
4) Confidence 0.05 Published 2003 Journal Dig Liver Dis Section Body Doc Link 14567460 Disease Relevance 0.08 Pain Relevance 0

General Comments

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