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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.44
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC4A1) transmembrane transport (SLC4A1)
Anatomy Link Frequency
smooth muscle 1
SLC4A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 97.92 Very High Very High Very High
Nicotine 362 97.58 Very High Very High Very High
Inflammation 3 92.80 High High
anesthesia 3 89.36 High High
addiction 11 79.52 Quite High
abdominal pain 1 77.16 Quite High
Migraine 2 75.00 Quite High
Angina 1 73.20 Quite High
backache 1 72.60 Quite High
cocaine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 7 99.76 Very High Very High Very High
Cancer 13 99.64 Very High Very High Very High
Necrosis 2 99.28 Very High Very High Very High
Fibrosis 1 97.92 Very High Very High Very High
INFLAMMATION 3 92.80 High High
Skin Cancer 3 89.64 High High
Malignant Neoplastic Disease 4 86.68 High High
Disease 2 85.60 High High
Embryonal Rhabdomyosarcoma 1 82.76 Quite High
Reprotox - General 2 2 82.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These cells were negative for CD68 but positive for AE1/AE3.
Positive_regulation (negative) of AE1
1) Confidence 0.49 Published 2003 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 14567739 Disease Relevance 0.47 Pain Relevance 0.19
Immunostains showed positive staining of tumor cells for HMB45, neuron-specific enolase, and calponin but were negative for S100 protein, melaninA, chromogranin, smooth muscle actin, desmin, caldesmon, epithelial membrane antigen, AE1/3, and synaptophysin.
Positive_regulation (negative) of AE1 in smooth muscle associated with cancer
2) Confidence 0.49 Published 2007 Journal J. Pediatr. Surg. Section Abstract Doc Link 17336201 Disease Relevance 0.77 Pain Relevance 0.09
By immunohistochemistry, the carcinoma cells were positive for cytokeratin AE1/AE3, cytokeratin 5/6, EMA, and MIC-2 (membranous staining).
Positive_regulation (positive) of AE1 associated with carcinoma
3) Confidence 0.20 Published 2006 Journal Pediatr. Dev. Pathol. Section Abstract Doc Link 16944983 Disease Relevance 0.60 Pain Relevance 0.12
Histological findings showed necrosis and spindle tumor cells which were positive for AE1/AE3 and vimentin, and negative for calretinin, D2-40, and WT-1.
Positive_regulation (positive) of AE1 associated with necrosis and cancer
4) Confidence 0.20 Published 2010 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 20163019 Disease Relevance 1.52 Pain Relevance 0.07
KE and WR shifted channel activation of IBa to more negative voltages.
Positive_regulation (activation) of WR
5) Confidence 0.02 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15448138 Disease Relevance 0.07 Pain Relevance 0.11
The monkeys were initially allowed to self-administer 10 µg/kg nicotine injections under a FR 1 schedule of reinforcement and, over subsequent sessions, the response requirement was gradually increased to FR 10.
Positive_regulation (increased) of FR 10 associated with nicotine
6) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794142 Disease Relevance 0 Pain Relevance 0.32
It took 25 to 101 sessions (mean 70±17 sessions) for monkeys to reach the final FR 10, time-out (TO) 60 sec schedule.
Positive_regulation (reach) of FR 10
7) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1794142 Disease Relevance 0 Pain Relevance 0.30

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