INT113862

Context Info Confidence 0.00 First Reported 2003 Last Reported 2003 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.06

nucleoplasm (NR1H4) lyase activity (CA2) response to stress (CA2) cytoplasm (CA2) cytosol (CA2) extracellular space (CA2)

Anatomy Link Frequency CAR 1 CA2 (Homo sapiens) NR1H4 (Homo sapiens)

Pain Link Frequency Relevance Heat Paracetamol 1 61.84

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Analysis of the activity of these variants indicates that both hCAR2 and hCAR3 lose the ability to heterodimerize with RXR and lack transactivation activity in cotransfection experiments where either full-length receptor or GAL4 DNA-binding domain/CAR ligand binding domain chimeras were utilized.

hCAR2 Neg (lack) Binding (heterodimerize) of RXR in CAR

1) Confidence 0.00 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 14567971 Disease Relevance 0 Pain Relevance 0.06

General Comments

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